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169: Protein Folding Errors Contribute to Aging and Disease
Jan 5, 2026
29m 17s
168: Best of 2025
Dec 29, 2025
22m 43s
167: Why Bats Don't Age and Why You Should Care with Dr. Emma Teeling
Dec 22, 2025
37m 08s
166: BioXcellerator - The Cutting Edge of Stem Cell Therapy
Dec 15, 2025
46m 18s
165: Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo
Dec 8, 2025
35m 14s
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| Date | Episode | Topics | Guests | Brands | Places | Keywords | Sponsor | Length | |
|---|---|---|---|---|---|---|---|---|---|
| 1/5/26 | 169: Protein Folding Errors Contribute to Aging and Disease✨ | protein foldingaging+5 | Dr. Judith Frydman | — | — | proteostasisprotein folding+5 | — | 29m 17s | |
| 12/29/25 | 168: Best of 2025✨ | agingartificial intelligence+4 | — | Living Longer for Busy PeopleLongevity Roadmap | — | longevityaging biology+3 | — | 22m 43s | |
| 12/22/25 | 167: Why Bats Don't Age and Why You Should Care with Dr. Emma Teeling✨ | longevityaging+4 | Dr. Emma Teeling | University College Dublin | — | batslongevity science+5 | — | 37m 08s | |
| 12/15/25 | 166: BioXcellerator - The Cutting Edge of Stem Cell Therapy✨ | stem cell therapyregenerative medicine+3 | BioXcellerator Team | Living Longer for Busy PeopleBioXcellerator | — | stem cellsregenerative therapies+3 | — | 46m 18s | |
| 12/8/25 | 165: Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo✨ | cellular cleanuphealthspan+3 | Dr. Ana Maria Cuervo | Einstein Medical College | — | agingcellular quality-control+5 | — | 35m 14s | |
| 12/1/25 | 164: Young Blood Can Rejuvenate Old Brains with Dr. Tony Wyss-Coray✨ | brain resilienceaging+5 | Dr. Tony Wyss-Coray | Stanford UniversityVero Bioscience+1 | — | brain resilienceaging process+5 | — | 34m 19s | |
| 11/24/25 | 163: How Mitochondrial Decline Drives Brain Aging with Dr. Francisco Gonzalez-Lima✨ | brain agingcognitive decline+3 | Dr. Francisco González-Lima | University of Texas at AustinAlzheimer's disease | — | mitochondrial declinebrain aging+3 | — | 59m 18s | |
| 11/17/25 | 162: The Habits of Healthy Aging with Dr. Kate Wolin✨ | healthy agingbehavioral epidemiology+4 | Dr. Kate Wolin | Longevity Roadmapdrkatewolin.com+2 | — | healthy agingbehavioral science+4 | — | 25m 22s | |
| 11/10/25 | 161: The Future of Tissue Regeneration with Dr. Jennifer Elisseeff✨ | tissue engineeringregenerative medicine+4 | Dr. Jennifer Elisseeff | Johns Hopkins University | — | tissue regenerationstem cells+6 | — | 30m 25s | |
| 11/3/25 | 160: Molecular Secrets of Aging Told Through Worms with Dr. Heidi Tissenbaum✨ | molecular geneticsaging+5 | Dr. Heidi Tissenbaum | UMass Chan Medical SchoolLiving Longer for Busy People | — | agingC. elegans+6 | — | 32m 49s | |
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| 10/27/25 | 159: How DNA Mutations and Epigenetic Drift Cause Aging with Prof. Jan Vijg | This week, Professor Jan Vijg joins us to discuss the intricate relationship between DNA mutations, epigenetic drift, and aging. He explains the differences between mutations and epigenetic changes, the role of environmental factors, and the potential for reversing epigenetic changes. The conversation also touches on the implications of somatic mutations and the future of longevity research, particularly in relation to DNA repair mechanisms. Learn more about Professor Jan Vijg: https://einsteinmed.edu/faculty/11318/jan-vijg - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com | — | ||||||
| 10/20/25 | 158: Sitting Is the New Smoking with Dr. Keith Diaz | In this episode, we are joined by Dr. Keith Diaz to discuss the significant health risks associated with prolonged sitting, likening it to smoking in terms of its dangers. He emphasizes the importance of regular movement, introducing the concept of 'movement snacks'—short bursts of activity that can mitigate the negative effects of sitting. We also cover the physiological mechanisms behind how movement affects blood sugar levels and inflammation, as well as insights from blue zones where people naturally incorporate more movement into their daily lives. Dr. Diaz advocates for personalized movement recommendations to help individuals improve their health outcomes. Learn more about Dr. Keith Diaz: https://www.columbiacardiology.org/profile/keith-diaz-phd - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com | — | ||||||
| 10/13/25 | 157: The Role of Surgery in Diabetes and Obesity with Dr. Mitchell Roslin | In this episode, we are joined by Dr. Mitchell Roslin to discuss the complexities of obesity. We explore the role of GLP-1 medications in weight management, the evolution of bariatric surgery, and the innovative SIPS procedure. Dr. Roslin emphasizes that obesity is not merely a result of poor lifestyle choices but involves intricate biological and hormonal mechanisms. He also highlights the importance of functional assessments in determining appropriate treatment for obesity, advocating for a more systematic approach to obesity management. Learn more about Dr. Mitchell Roslin: https://faculty.medicine.hofstra.edu/4990-mitchell-roslin - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com | — | ||||||
| 10/6/25 | 156: Investing in the Business of Aging with Dr. Karl Pfleger | In this episode, Dr. Karl Pfleger joins us to discuss the evolving landscape of longevity research and investment. He emphasizes the shift from disease-specific approaches to understanding aging as a multifaceted process that underpins many chronic diseases. Dr. Pfleger outlines his investment strategies in the aging biotech sector, highlighting the importance of addressing various sub-pathologies of aging. He also discusses the concept of longevity escape velocity, the challenges of proving longevity therapies, and the role of aging clocks in research. Learn more about Dr. Karl Pfleger: https://x.com/karlpfleger?lang=en - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com | — | ||||||
| 9/29/25 | 155: Can Psilocybin Extend Cellular Lifespan? with Dr. Louise Hecker | In this episode, Dr. Louise Hecker joins us to discuss her groundbreaking research on psilocybin, exploring its potential to extend cellular lifespan and improve health outcomes in aging. We delve into the mechanisms behind psilocybin's effects, findings from animal studies, and the challenges faced in conducting research on this Schedule I substance. Dr. Hecker emphasizes the importance of understanding optimal dosing protocols and safety considerations for future applications of psilocybin in geroprotection. Learn more about Dr. Louise Hecker: https://med.emory.edu/directory/profile/?u=LHECKER - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com | — | ||||||
| 9/22/25 | 154: Is Telomere Length Shortening the Master Switch of Aging? with Dr. Bill Andrews | In this episode, Dr. Bill Andrews joins Dr. Buck Joffrey to discuss the critical role of telomeres and telomerase in aging and cellular health. He explains how telomeres shorten with each cell division, leading to aging and cellular senescence. Dr. Andrews emphasizes the importance of inducing telomerase to potentially reverse aging and shares insights from his research on telomerase inducers. He also addresses the challenges in longevity research, the relationship between telomeres and the hallmarks of aging, and the potential of gene therapy. The conversation concludes with a discussion on lifestyle factors that can influence aging and the future of aging research. Learn more about Dr. Bill Andrews: https://sierrasci.com/dr-bill-andrews/ Get your first bottle of Telo-Vital for 55% off with free shipping to the US, UK, Canada, Mexico, Australia, New Zealand, and over 20 European Countries: https://longevityroadmap.thegoodinside.com/special-offer-telo-vital-lp - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/ | — | ||||||
| 9/15/25 | 153: T Cells, Aging, and Extreme Life Extension with Dr. Derya Unutmaz | Dr. Derya Unutmaz joins Dr. Buck Joffrey to discuss the critical role of T cells in the immune system, their changes with aging, and the implications for chronic diseases. He emphasizes the importance of thymus regeneration and the microbiome's influence on health. The discussion also covers advancements in engineering immune cells for cancer treatment and the potential of AI in revolutionizing aging research and drug discovery. Unutmaz expresses optimism about the future of aging research, highlighting the need for a shift in how aging is perceived in the medical community. Learn more about Dr. Derya Unutmaz: https://www.jax.org/research-and-faculty/faculty/derya-unutmaz - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/ | — | ||||||
| 9/8/25 | 152: The Role of Vitamin A in Brain Health with Prof. Peter McCaffery | In this episode, Professor Peter McCaffery joins Dr. Buck Joffrey to discuss the multifaceted role of Vitamin A in brain health, particularly its function as a signaling molecule that influences neuroplasticity and cognitive functions. He elaborates on the challenges of Vitamin A supplementation, especially in aging populations, and the implications of retinoic acid signaling in neurodegenerative diseases like Alzheimer's. The discussion also touches on the importance of skin health in the context of systemic aging and the potential for targeted therapies to enhance Vitamin A signaling without the risks associated with traditional supplementation. Learn more about Professor Peter McCaffery: https://www.abdn.ac.uk/people/peter.mccaffery - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/ | — | ||||||
| 9/1/25 | 151: Does Astaxanthin Increase Longevity? with Dave Watumull | In this episode, Dave Watumull joins Dr. Buck Joffrey to discuss the benefits and mechanisms of astaxanthin, a powerful antioxidant and anti-inflammatory compound. He explains its role in longevity, particularly through the Interventions Testing Program (ITP), where astaxanthin was shown to extend lifespan in male mice by 12%. The discussion also covers the safety profile, bioavailability, and clinical studies demonstrating cardiovascular benefits. Gender differences in efficacy are explored, along with practical advice on dosage and where to find astaxanthin products. Learn more about AX3: https://ax3.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/ | — | ||||||
| 8/25/25 | 150: The Microbiome's Role in Aging and Healthspan with Dr. Sean Gibbons | Dr. Sean Gibbons joins Dr. Buck Joffrey to discuss the complexities of the gut microbiome, its evolution, and its significant role in health and longevity. He explains how our microbiome is established at birth, how it changes throughout life, and the impact of diet and lifestyle on its composition. The discussion also covers the challenges of modifying the microbiome, the potential of precision nutrition, and the emerging field of fecal transplants. Dr. Gibbons emphasizes the importance of butyrate, a beneficial short-chain fatty acid produced by gut bacteria, and the future of microbiome research in developing targeted interventions for health improvement. Learn more about Dr. Sean Gibbons: https://isbscience.org/people/sean-gibbons-phd/?tab=biography - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/ | — | ||||||
| 8/18/25 | 149: How Dental Health Impacts Longevity with Dr. Ellie Phillips | Dr. Ellie Phillips, DDS, joins Dr. Buck Joffrey to explain how oral pathogens contribute to chronic inflammation and conditions such as cardiovascular disease, Alzheimer's, and adverse pregnancy outcomes. She shares the science behind xylitol, saliva-driven remineralization, and practical strategies for supporting a healthy oral microbiome to reduce systemic risk. Learn more about Dr. Ellie Phillips: https://drellie.com/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/ | — | ||||||
| 8/11/25 | 148: Dr. Kevin J. Tracey - Stimulating the Vagus Nerve to Reduce Inflammation and Improve Healthspan | Dr. Kevin J. Tracey, neurosurgeon, immunologist, and pioneer in bioelectronic medicine, discusses the discovery of the inflammatory reflex and how vagus nerve stimulation can precisely regulate immune activity without immunosuppression. He explains its clinical application in rheumatoid arthritis, potential use in Crohn's disease, multiple sclerosis, and metabolic disorders, and its implications for extending healthspan. Watch the full episode to explore how targeting neural circuits could redefine the treatment of inflammation. Get Dr. Kevin J. Tracey's book, The Great Nerve: https://www.penguinrandomhouse.com/books/746339/the-great-nerve-by-kevin-j-tracey-md/ Learn more about Dr. Tracey: https://feinstein.northwell.edu/institutes-researchers/our-researchers/kevin-j-tracey-md - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/ | — | ||||||
| 8/4/25 | 147: The Wrong Vitamin E Supplement Can Hurt You with Dr. Barrie Tan | In this conversation, Dr. Barrie Tan joins Dr. Buck Joffrey to discuss the significance of tocotrienols—a lesser-known form of vitamin E—and their potential role in preventing chronic disease and promoting healthy aging. Dr. Tan explains the differences between tocopherols and tocotrienols, the role of vitamin E in human health, and highlights the annatto plant as a key natural source of tocotrienols. The discussion also touches on clinical trials, the anti-inflammatory effects of tocotrienols, and how they work in synergy with other supplements. Learn more about Dr. Barrie Tan: https://barrietan.com/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/ | — | ||||||
| 7/28/25 | 146: AMA President Dr. Bobby Mukkamala - Healthspan-Centric Medical Care in America | Joining Dr. Buck Joffrey this week, Dr. Bobby Mukkamala shares his journey from aspiring cardiothoracic surgeon to becoming the president of the American Medical Association. He discusses his personal health challenges, including a brain tumor diagnosis, and how it has shaped his perspective on healthcare. The conversation delves into the importance of preventative medicine, the impact of the Flint water crisis, and the role of the AMA in shaping the future of healthcare, particularly in the realm of longevity and AI. Dr. Mukkamala emphasizes the need for a shift from reactive to proactive healthcare and addresses the challenges posed by influencer medicine and misinformation. Learn more about Dr. Bobby Mukkamala: https://www.ama-assn.org/about/board-trustees/bobby-mukkamala-md - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/ | — | ||||||
| 7/21/25 | 145: Why Some Animals Live Longer Than Others with Dr. Steven Austad | In this conversation, Dr. Buck Joffrey and Dr. Steven Austad discusse the biology of aging, the evolutionary aspects of longevity, and the potential for genetic technologies to extend human health span. Dr. Austad emphasizes the complexity of aging, the importance of glucose control, and the need for further research into species that exhibit remarkable longevity. The discussion also touches on the challenges and ethical considerations of manipulating human genetics for longevity. Learn more about Dr. Steven Austad: https://www.stevenaustad.com/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/ | — | ||||||
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