160: Molecular Secrets of Aging Told Through Worms with Dr. Heidi Tissenbaum

160: Molecular Secrets of Aging Told Through Worms with Dr. Heidi Tissenbaum

From Longevity Roadmap by Buck Joffrey

November 3, 2025 · 33 min

About this episode

Dr. Heidi Tissenbaum discusses the insights gained from C. elegans worms regarding the biology of aging and longevity pathways.

Dr. Heidi Tissenbaum, a molecular geneticist at UMass Chan Medical School, joins Dr. Buck Joffrey to explore what C. elegans worms have revealed about the biology of aging. She explains how these simple organisms helped uncover key longevity pathways—like insulin/IGF-1 signaling and sirtuins—that also exist in humans. The conversation dives into the balance between stress and resilience, the role of IGF-1 in muscle health and lifespan, and why she believes true longevity breakthroughs will require understanding how the body's systems communicate as a whole. Learn more about Dr. Heidi Tissenbaum: https://profiles.umassmed.edu/display/133231 - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

People in this episode

Host: Dr. Buck Joffrey

Guest: Dr. Heidi Tissenbaum

Topics covered

  • molecular genetics
  • aging
  • C. elegans
  • longevity pathways
  • insulin signaling
  • sirtuins
  • muscle health

Keywords

  • aging
  • C. elegans
  • longevity
  • insulin signaling
  • sirtuins
  • muscle health
  • resilience
  • IGF-1

Mentioned in this episode

Organizations: UMass Chan Medical School

Books & works: Living Longer for Busy People

More episodes of Longevity Roadmap

Explore listener stats, chart rankings, contacts and more on the Longevity Roadmap podcast page.