
S 891: The Truth About Leaky Gut: Intestinal Permeability, Root Causes, and Science-Backed Solutions
From Sam Miller Science by Sam Miller
March 27, 2026 · 39 min · Episode 891
About this episode
This episode explains intestinal permeability, its causes, and science-backed solutions for leaky gut.
"Leaky gut" is a term that sparks debate, often dismissed as a fad or exaggerated as the root of all illness. This episode cuts through the noise to explain what intestinal permeability truly is: a spectrum from normal physiological function to pathological barrier dysfunction. We explore the real causes of this dysfunction, from chronic stress and poor sleep to medications and metabolic issues. Topics discussed: - Defining leaky gut - The difference between normal and pathological gut barrier function - Leaky gut’s role in neuroinflammation and neurodegeneration - Common causes - The importance of a healthy microbiome - Foundational solutions - Metabolic health as first step to gut repair - Targeted supplementation ---------- My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization www.metabolismschool.com ---------- [Free] Metabolism School 101: The Video Series http://www.metabolismschool.com/metabolism-101 ---------- Subscribe to My Youtube Channel…
Topics covered
- Defining leaky gut
- Normal and pathological gut barrier function
- Leaky gut’s role in neuroinflammation and neurodegeneration
- Common causes of leaky gut
- Importance of a healthy microbiome
- Foundational solutions for gut health
- Metabolic health and gut repair
- Targeted supplementation
Keywords
- intestinal permeability
- chronic stress
- poor sleep
- metabolic issues
- microbiome
Mentioned in this episode
Products: Podcast, Functional Nutrition and Metabolism Specialization, Metabolism School 101
Books & works: The Truth About Leaky Gut: Intestinal Permeability, Root Causes, and Science-Backed Solutions
Places: U.S.
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