S 891: The Truth About Leaky Gut: Intestinal Permeability, Root Causes, and Science-Backed Solutions

S 891: The Truth About Leaky Gut: Intestinal Permeability, Root Causes, and Science-Backed Solutions

From Sam Miller Science by Sam Miller

March 27, 2026 · 39 min · Episode 891

About this episode

This episode explains intestinal permeability, its causes, and science-backed solutions for leaky gut.

"Leaky gut" is a term that sparks debate, often dismissed as a fad or exaggerated as the root of all illness. This episode cuts through the noise to explain what intestinal permeability truly is: a spectrum from normal physiological function to pathological barrier dysfunction. We explore the real causes of this dysfunction, from chronic stress and poor sleep to medications and metabolic issues. Topics discussed: - Defining leaky gut - The difference between normal and pathological gut barrier function - Leaky gut’s role in neuroinflammation and neurodegeneration - Common causes - The importance of a healthy microbiome - Foundational solutions - Metabolic health as first step to gut repair - Targeted supplementation ---------- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.metabolismschool.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ---------- [Free] Metabolism School 101: The Video Series ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.metabolismschool.com/metabolism-101⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ---------- Subscribe to My Youtube Channel…

Topics covered

  • Defining leaky gut
  • Normal and pathological gut barrier function
  • Leaky gut’s role in neuroinflammation and neurodegeneration
  • Common causes of leaky gut
  • Importance of a healthy microbiome
  • Foundational solutions for gut health
  • Metabolic health and gut repair
  • Targeted supplementation

Keywords

  • intestinal permeability
  • chronic stress
  • poor sleep
  • metabolic issues
  • microbiome

Mentioned in this episode

Products: Podcast, Functional Nutrition and Metabolism Specialization, Metabolism School 101

Books & works: The Truth About Leaky Gut: Intestinal Permeability, Root Causes, and Science-Backed Solutions

Places: U.S.

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