SCCM Podcast

What has changed in the updated 2026 Surviving Sepsis Campaign (SSC) guidelines for children? In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Elizabeth H. Mack, MD, MS, FCCM, speaks with pediatric SSC guideline cochairs Scott L. Weiss, MD, MSCE, FCCM, and Pierre Tissieres, MD, DSc, about the latest guideline recommendations for the care of children with sepsis and septic shock. The updated guidelines emphasize the early identification of sepsis, an evolution to a more targeted way of treatment, and a more practical approach to guideline implementation. Other aspects of the previous guidelines, such as lactate measurements, continuous reassessment, and the role of point-of-care monitoring, were reinforced in the 2026 guidelines. The guidelines, “Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026,” were released in the April issue of Pediatric Critical Care Medicine. Key updates and new areas of emphasis include: A more nuanced approach to sepsis screening and early recognition New guidance on supplemental oxygen, including limiting hyperoxia and using more conservative oxygenation targets in children with septic shock New patient, intervention, comparison, outcome questions related to immune dysregulation, highlighting an important area for future research New attention to post-sepsis morbidity Greater emphasis on long-term follow-up and risk assessment for children who survive sepsis Scott L. Weiss, MD, MSCE, FCCM, is division chief of critical care and vice-chair of research at Nemours Children’s Hospital (DuPont)-Delaware and professor of pediatrics and pathology and genomic medicine at the Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Pierre Tissieres, MD, DSc, is a professor of pediatrics and head of Pediatric ICU and Neonatal Medicine at Paris South University Hospitals in Paris, France. This podcast is sponsored by Vantive. At Vantive, our mission to extend lives and expand possibilities starts with a commitment to continuous learning. We are committed to partnering with the medical community to support vital organ therapy innovation grounded in clinical evidence and focused on improving patient outcomes. The recent publication on endotoxic septic shock centers on an evidence-based approach to address clinical challenges in critical care and beyond as highlighted in our press release. Resources referenced in this podcast: Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026 Executive Summary of Society of Critical Care Medicine 2026 Guidelines on the Care and Management of Pediatric and Neonatal Intensive Care Patients at the End of Life International Consensus Criteria for Pediatric Sepsis and Septic Shock

There is enormous heterogeneity in clinical outcomes and severity of septic shock, with some patients needing only supportive care in the ICU and others progressing to multiorgan system failure and death. How can clinicians identify patients at higher risk of death? In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Marilyn Bulloch, PharmD, BCPS, FCCM, is joined by John A. Kellum, MD, FCCM, to discuss high endotoxin activity as a possible endotype for septic shock. Dr. Kellum’s article, “Organ Failure, Endotoxin Activity, and Mortality in Septic Shock,” was published in the September 2025 compendium of Critical Care Explorations. Dr. Kellum is a professor and director of the Center for Critical Care Nephrology, as well as vice chair for the Department of Critical Care Medicine, at the University of Pittsburgh in Pittsburgh, Pennsylvania, USA. The study used a novel biomarker called the endotoxin activity assay (EAA) to detect endotoxin in the blood. While the EAA is not good at identifying patients who are at risk for sepsis, Dr. Kellum said that, when combined with organ failure, it identifies patients at high risk for endotoxic septic shock. In the study, these patients had a mortality rate of 60%. Neither the EAA nor the anti-endotoxin therapy is readily available. And, although endotoxic septic shock is rare, occurring in only a quarter of patients with septic shock, Dr. Kellum hopes that, through precision medicine, segmenting this population into treatable subgroups may allow better diagnostics and opportunities to develop or repurpose therapies in the future. This episode is sponsored by Prenosis. Resources referenced in this episode: Organ Failure, Endotoxin Activity, and Mortality in Septic Shock (Molinari L, et al. Crit Care Explor. 2025;7:e1308) Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis (Seymour CW, et al. JAMA. 2019;321:2003-2017) Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study (TIGRIS) (ClinicalTrials.gov. ID NCT03901807. Last update posted January 9, 2026)

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Elizabeth H. Mack, MD, MS, FCCM, speaks with Nadir Yehya, MD, MSCE, an attending physician in the Pediatric Sepsis Program and the Division of Critical Care Medicine at the Children's Hospital of Philadelphia in Philadelphia, Pennsylvania, USA. They discuss Dr. Yehya’s study, “Parent and Provider Perspectives on Short-Term Outcomes of Critically Ill Ventilated Children,” published in the September 2025 issue of Pediatric Critical Care Medicine. The study explores whether widely used composite clinical outcomes such as ventilator-free days truly reflect what families value most when their child is in the pediatric intensive care unit (PICU). Dr. Yehya discusses how the project emerged from a long-standing question in pediatric critical care research: Are the outcomes we measure in clinical trials aligned with the priorities and lived experiences of families? Because mortality is low in pediatrics, composite short-term outcomes such as ventilator-free days, ICU-free days, and hospital-free days are commonly used. However, little is known about whether these metrics are truly patient- and family-centered. Using survey data from parents and PICU clinicians, the study found strong agreement between parents and clinicians on the importance of minimizing duration of invasive mechanical ventilation. But parents and clinicians diverged on other short-term outcomes. Families ranked oxygen duration as more important than ICU or hospital length of stay, reflecting concerns about ongoing medical needs, missed work, and the possibility of going home on oxygen. Clinicians prioritized ICU and hospital days over oxygen use. Substantial variation was also found within both groups. Dr. Yehya highlights the value of feedback from patient and family advisory councils in designing this type of research, explaining that such feedback informed the study’s instrument design and family approach. He calls for deeper investigation into post-discharge recovery, functional outcomes, and long-term developmental trajectories—areas families consistently identify as their greatest concerns. Resources referenced in this episode: Parent and Provider Perspectives on Short-Term Outcomes of Critically Ill Ventilated Children (Shannon MM, et al. Pediatr Crit Care Med. 2025;26:e1149-e1153)

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Kyle B. Enfield, MD, FCCM, speaks with Sumeet Rai, PhD, FCICM, senior intensivist at Canberra Hospital, about his study, “Pawsitive Care: Canine-Assisted Intervention for Anxiety in ICU Patients and Family Members: A Single-Center, Single-Arm Study,” published in the May 2025 compendium of Critical Care Explorations. Dr. Rai explains how positive anecdotal experiences of animal therapy in the ICU inspired his team to conduct this study. Guided by infection control protocols, they implemented a program allowing accredited therapy dogs to visit patients and families for 15- to 20-minute sessions. More than 60% of patients and more than 90% of family members had a clinically meaningful reduction in anxiety scores, and patients reported decreased pain. No adverse events were observed, demonstrating the feasibility and safety of this approach. Dr. Rai addresses the study’s limitations, such as the impracticality of conducting a randomized trial, and highlights the need for research into staff well-being, which appeared to benefit from therapy dog visits. He also underscores the importance of a safety program, including infection control precautions. This episode offers practical insights for implementing animal therapy programs in the ICU and invites listeners to consider new approaches to improving mental health and well-being for patients, families, and staff. Resources referenced in this episode: Pawsitive Care: Canine-Assisted Intervention for Anxiety in ICU Patients and Family Members: A Single-Center, Single-Arm Study (Cook K, et al. Crit Care Explor. 2025;7:e1258).

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Diane C. McLaughlin, DNP, AGACNP-BC, CCRN, FCCM, speaks with Muhammad Mansoor Mohiuddin, MD, MBBS, DSc (Hon), FAST, director of the Cardiac Xenotransplantation Program at the University of Maryland School of Medicine, about his Thought Leader presentation at the 2025 Critical Care Congress, The Remarkable Potential of Xenotransplantation, and his groundbreaking work on that subject. Dr. Mohiuddin discusses the need to address the global shortage of donated organs and the use of genetically modified pig organs as a viable solution. He explains the science behind xenotransplantation, including the use of CRISPR-Cas9 gene editing technology to delete immunogenic pig genes and insert human-compatible genes. The conversation explores the unique immunologic challenges of xenotransplantation, particularly antibody-mediated rejection and the need for tailored immunosuppression protocols. Ethical considerations include religious perspectives and public opinion. Dr. Mohiuddin emphasizes the importance of continued research funding and collaboration with industry partners to advance clinical trials and refine genetic modifications. Listeners will gain insight into how decades of research are transforming xenotransplantation and its potential to extend life and reshape the future of organ transplantation.

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Samantha Gambles Farr, MSN, AG-ACNP, FNP-C, RNFA, speaks with Brian Boling, DNP, AGACNP-BC, FCCM, an advanced practice provider (APP) in the Department of Anesthesiology, Division of Critical Care Medicine, at the University of Kentucky and host of the Critical Care Scenarios podcast. They explore the challenges and opportunities facing novice nurses and APPs as they transition into new roles in critical care. Drawing from his own nontraditional path into nursing and advanced practice, Dr. Boling shares how self-directed learning—through podcasts, blogs, and social media—can supplement formal education and foster professional growth. He emphasizes the importance of building a personalized curriculum that balances foundational knowledge with emerging trends and encourages learners to focus not only on hot topics but also on the essential, everyday skills that drive patient outcomes. The conversation highlights strategies for identifying credible educational resources and maintaining work-life balance while pursuing lifelong learning. Listeners will gain insights into how experienced clinicians can support novice colleagues through informal mentorship and bedside teaching and how honesty about knowledge gaps can lead to deeper learning. Whether you're a new graduate, a transitioning clinician, or a seasoned clinician looking to mentor others, this episode offers practical guidance for education, growth, and leadership in critical care.

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Diane McLaughlin, DNP, AGACNP-BC, CCRN, FCCM, is joined by John Appino, MBA, founder and CEO of Contract Diagnostics, and Ryan Hakimi, DO, MS, NVS, RPNI, CPB, FNCS, FCCM, neurointensivist at Prisma Health in Greenville, South Carolina, for a conversation on salary and contract negotiations for advanced practice providers (APPs). The guests explore the nuances of evaluating job offers and negotiating compensation, as well as prioritizing onboarding, mentorship, and job fit. Dr. Hakimi shares insights from his leadership roles in academic neuro-ICUs and his longstanding advocacy for APPs, while Mr. Appino offers a strategic perspective on contract structures, compensation models, and negotiation tactics. The discussion highlights the variability in contract practices across academic and private institutions, the importance of defining full-time employment expectations, and the role of offer letters versus formal contracts. Listeners will learn how to approach salary discussions with confidence, including when to negotiate, which data to reference (e.g., Medical Group Management Association and American Medical Group Association benchmarks), and how to assess a job offer beyond salary. This episode is valuable for APPs at any career stage seeking fair compensation and sustainable career growth. It emphasizes that successful negotiations are not just about salary—they are also about clarity, support, and long-term professional satisfaction.

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Diane C. McLaughlin, DNP, AGACNP-BC, CCRN, FCCM, welcomes guests Kaitlin M. Alexander, PharmD, BCCCP, and Ankit Sakhuja, MD, MS, FCCM, from SCCM’s Leadership, Empowerment, and Development (LEAD) Program, to discuss the use of AI in critical care education and clinical practice. Dr. Alexander is a clinical associate professor in the Department of Pharmacy Education and Practice at University of Florida. Dr. Sakhuja is the director of artificial intelligence and informatics at the Institute for Critical Care Medicine and director of clinical informatics research in the Division of Data-Driven and Digital Medicine. The discussion highlights how critical care educators and clinicians benefit from learning how to use AI and understanding its benefits and limitations. Incorporating AI into critical care education teaches students how to use AI responsibly in school and later in clinical practice. Clinicians should understand the utility of different AI models for patient care and be well versed in the ethical and legal treatment of patient data. Drs. Alexander and Sakhuja provide examples of practical uses for AI in critical care. AI can help students test their knowledge with interactive case simulations paired with discussion with instructors and peers. AI can analyze vast amounts of patient data, supporting clinical decision-making. The guests encourage clinicians and educators in critical care to engage with AI and contribute to its responsible use. Listeners will gain valuable insights into the uses of AI.

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Kyle B. Enfield, MD, FCCM, welcomes Vincenzo Russotto, MD, of the University of Turin in Turin, Italy to discuss Dr. Russotto’s article, “Induction Agents for Tracheal Intubation in Critically Ill Patients,” published in the January 2025 issue of Critical Care Medicine. Drs. Enfield and Russotto explore the decision of which induction drugs to use for patients undergoing tracheal intubation. They discuss research challenges such as the ethics of which drugs can be tested on patients and the emergent nature of many tracheal intubations. Dr. Russotto discusses the advantages and disadvantages of ketamine as an induction agent and describes current clinical thinking on etomidate and propofol. His study made no definitive conclusions but found evidence that ketamine may have a safer profile and etomidate and propofol may be associated with negative effects. Dr. Russotto emphasizes the need to individualize patient treatment and shares examples of induction agent combinations. He encourages clinicians to consider hemodynamic optimization along with the use of intubation agents. Listeners will gain insights to inform patient care. Resources referenced in this episode: Induction Agents for Tracheal Intubation in Critically Ill Patients (Kotani Y, et al. Crit Care Med. 2025;53:e173-e181).

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Maureen A. Madden, DNP, RN, CPNC-AC, CCRN, FCCM, welcomes Christopher D. Newman, MBA, PA-C, FCCM, of Children's Hospital Colorado, and Victoria Howard, PA-C, of the University of Rochester to discuss professional advancement tracks for advanced practice providers (APPs). APP professional advancement programs aim to improve retention and engagement. Mr. Newman and Ms. Howard highlight additional benefits as well. They explain how the pilot professional advancement tracks at their institutions address specific needs of APPs. Mr. Newman’s program addresses the challenge of recognizing and supporting the nonclinical contributions of predominantly clinical faculty such as APPs. Ms. Howard’s program recognizes APPs’ careers beginning at an early stage and incorporates salary advancement into the program. The guests discuss the practical challenges of implementing a professional advancement model, including finding financial resources, obtaining institutional buy-in, and making the recognition relevant and meaningful to APPs’ work. Both guests emphasize that professional advancement programs should motivate and engage APPs over the course of their careers and encourage more appreciation for their work. The conversation will motivate listeners to explore similar career development programs at their own institutions.

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Elizabeth H. Mack, MD, MS, FCCM, speaks with Anil Sachdev, MD, FICCM, of the Institute of Child Health, Sir Ganga Ram Hospital in New Delhi, India about his team’s study, “Transpulmonary Pressure-Guided Mechanical Ventilation in Severe Acute Respiratory Distress Syndrome in the PICU: Single-Center Retrospective Study in North India, 2018–2021,” published in the March 2025 issue of Pediatric Critical Care Medicine. Dr. Sachdev explains the development and implementation at his institution of a protocol for transpulmonary pressure (TPP) monitoring in pediatric patients with severe acute respiratory distress syndrome. His team compared outcomes of patients receiving TPP-guided ventilation with those receiving conventional mechanical ventilation. Study findings suggested that TPP monitoring enabled the use of higher positive end-expiratory pressure with greater clinician confidence, resulting in improved oxygenation. Study limitations included small sample size and challenges of equipment availability, cost, and obtaining parental consent. The study was conducted in part during the COVID-19 pandemic, which further constrained resources and study participation. The discussion concludes with Dr. Sachdev’s insights into practical challenges of TPP monitoring, including inserting delicate esophageal catheters in infants and young children and the necessity of correct catheter position for accurate readings. Resources referenced in this episode: Transpulmonary Pressure-Guided Mechanical Ventilation in Severe Acute Respiratory Distress Syndrome in the PICU: Single-Center Retrospective Study in North India, 2018–2021 (Sachdev A, et al. Pediatr Crit Care Med. 2025;26:e354-e363).

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Marilyn N. Bulloch, PharmD, BCPS, FCCM, speaks with Christy C. Forehand, PharmD, BCCCP, FCCM, about retaining highly skilled pharmacists in the ICU setting. Dr. Forehand, a clinical pharmacy specialist and residency program director at Augusta University Medical Center and the University of Georgia College of Pharmacy, shares evidence-based insights and personal reflections on how pharmacist retention directly impacts quality and safety in patient care. The conversation highlights growing concerns around burnout and attrition among ICU pharmacists, underscoring how their involvement improves clinical and economic outcomes—ranging from medication safety and reduced ventilator days to optimized transitions of care. Drawing on American College of Clinical Pharmacy (ACCP) publications and American Society of Health-System Pharmacists (ASHP) guidance, Dr. Forehand outlines strategies for building retention plans that prioritize recognition, advancement opportunities, career mentorship, and structural supports such as protected administrative time. She emphasizes how institutional practices such as improved scheduling, remote work models, and role-specific stipends can prevent burnout while reinforcing team trust and efficiency. Resources referenced in this episode: SCCM’s Leadership, Empowerment, and Development (LEAD) Program, which supports professional development Rewards, Recognition, and Advancement for Clinical Pharmacists (Bondi DS, et al. J Am Coll Clin Pharm. 2023;6:427-439)

Mark E. Hamill, MD, FCCM, a trauma surgeon, intensivist, and past chair of the Society of Critical Care Medicine’s (SCCM) Fundamental Critical Care Support (FCCS) Committee, discusses the evolution, impact, and future of training of critical care. In this SCCM podcast, Dr. Hamill reflects on his decade-long journey with FCCS, beginning with local implementation at his former institution to eventually leading national and international Fundamentals efforts. He shares powerful stories from training initiatives in Rwanda, Palestine, and war-time Ukraine—highlighting the program’s global reach and ability to empower frontline clinicians. Central to the discussion is Dr. Hamill’s published study, “Impact of Standardized Multidisciplinary Critical Care Training on Confidence with Critical Illness and Attitudes Towards Interprofessional Education and Multidisciplinary Care” (Hamill ME, et al. J Intensive Care Med. 2024;39:320-327). The study analyzed survey data from 328 multidisciplinary learners and demonstrated significant increases in participants’ self-assessed confidence across key critical care domains—including sepsis, respiratory failure, shock, and neurologic illness—after completing FCCS. The findings support what many instructors have long observed anecdotally: FCCS builds competence, fosters interprofessional collaboration, and enhances learners’ readiness to respond to critically ill patients. Dr. Hamill also explains the study’s methodology, including retrospective precourse analysis and a three-month follow-up, and shares insights about future research plans involving simulation-based evaluation to assess knowledge retention and behavior change. Whether you are considering hosting a Fundamentals course, becoming an instructor, or expanding your training programs, this podcast episode offers compelling evidence of FCCS’s lasting value in skills acquisition and elevating the culture of care.