Talk Python To Me

OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But here's the twist Charlie Marsh shared with me: he thinks they may ship more open source at OpenAI than they ever did at Astral. On this episode, we get into the acquisition, the mixed feelings, the future of your favorite Python tools, and what it's like to build right at the center of the AI universe.

You've built your FastAPI app, it's running great locally, and now you want to share it with the world. But then reality hits -- containers, load balancers, HTTPS certificates, cloud consoles with 200 options. What if deploying was just one command? That's exactly what Sebastian Ramirez and the FastAPI Cloud team are building. On this episode, I sit down with Sebastian, Patrick Arminio, Savannah Ostrowski, and Jonathan Ehwald to go inside FastAPI Cloud, explore what it means to build a "Pythonic" cloud, and dig into how this commercial venture is actually making FastAPI the open-source project stronger than ever.

Your cloud SSD is sitting there, bored, and it would like a job. Today we’re putting it to work with DiskCache, a simple, practical cache built on SQLite that can speed things up without spinning up Redis or extra services. Once you start to see what it can do, a universe of possibilities opens up. We're joined by Vincent Warmerdam to dive into DiskCache.

Python in 2025 is in a delightfully refreshing place: the GIL's days are numbered, packaging is getting sharper tools, and the type checkers are multiplying like gremlins snacking after midnight. On this episode, we have an amazing panel to give us a range of perspectives on what matter in 2025 in Python. We have Barry Warsaw, Brett Cannon, Gregory Kapfhammer, Jodie Burchell, Reuven Lerner, and Thomas Wouters on to give us their thoughts.

For years, building interactive widgets in Python notebooks meant wrestling with toolchains, platform quirks, and a mountain of JavaScript machinery. Most developers took one look and backed away slowly. Trevor Manz decided that barrier did not need to exist. His idea was simple: give Python users just enough JavaScript to unlock the web’s interactivity, without dragging along the rest of the web ecosystem. That idea became anywidget, and it is quickly becoming the quiet connective tissue of modern interactive computing. Today we dig into how it works, why it has taken off, and how it might change the way we explore data.

In this episode, I’m talking with Vincent Warmerdam about treating LLMs as just another API in your Python app, with clear boundaries, small focused endpoints, and good monitoring. We’ll dig into patterns for wrapping these calls, caching and inspecting responses, and deciding where an LLM API actually earns its keep in your architecture.