The Bob Harrington Show

Drs Bob Harrington and Bob Wachter discuss the use of AI in healthcare, and Dr Wachter's latest book, A Giant Leap. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington A Giant Leap. How AI Is Transforming Healthcare and What That Means for Our Future https://www.penguinrandomhouse.com/books/776443/a-giant-leap-by-robert-wachter-md/ Revisiting the Time Needed to Provide Adult Primary Care https://doi.org/10.1007/s11606-022-07707-x Bob Wachter, Digital Doctor Author, Interviewed https://www.medscape.com/viewarticle/848172 Evidence based medicine: what it is and what it isn't https://doi.org/10.1136/bmj.312.7023.71 Your A.I. Radiologist Will Not Be With You Soon https://www.nytimes.com/2025/05/14/technology/ai-jobs-radiologists-mayo-clinic.html What This Computer Needs Is a Physician: Humanism and Artificial Intelligence https://doi.org/10.1001/jama.2017.19198 Reliability of LLMs as medical assistants for the general public: a randomized preregistered study https://doi.org/10.1038/s41591-025-04074-y Expressing stigma and inappropriate responses prevents LLMs from safely replacing mental health providers https://arxiv.org/abs/2504.18412 Perceptions and Opinions of Patients About Mental Health Chatbots: Scoping Review https://doi.org/10.2196/17828 User Intentions to Use ChatGPT for Self-Diagnosis and Health-Related Purposes: Cross-sectional Survey Study https://doi.org/10.2196/47564 KFF Health Misinformation Tracking Poll: Artificial Intelligence and Health Information https://www.kff.org/public-opinion/kff-health-misinformation-tracking-poll-artificial-intelligence-and-health-information/ You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Drs Harrington and Gibson's annual review of cardiovascular medicine: ACS guidelines, antiplatelet management, GLP-1s, and ever lower LDL-C with drugs or even gene editing are among the highlights. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington New ACS Guidelines 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes https://doi.org/10.1161/CIR.0000000000001309 ACS Guideline Chair and Vice-Chair Discussion https://www.medscape.com/viewarticle/acs-guidelines-2025-key-points-chair-and-vice-chair-2025a100093l Antiplatelet/Antithrombotic Strategies Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes (NEO-MINDSET) https://www.nejm.org/doi/full/10.1056/NEJMoa2507980 Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC) https://www.nejm.org/doi/full/10.1056/NEJMoa2507532 Bayesian Machine Learning Model Guiding Iterative, Personalized Anticoagulant Dosing Decision-Making : ENGAGE AF-TIMI 48 Trial Analysis https://doi.org/10.1016/j.jacadv.2025.102504 Factor XI Inhibitors Bristol Myers, J&J Stop Blood Clotting Drug Trial After Interim Review https://www.medscape.com/s/viewarticle/bristol-myers-j-j-stop-blood-clotting-drug-trial-after-2025a1000vqu Bayer's Asundexian Met Primary Efficacy and Safety Endpoints in Landmark Phase III OCEANIC-STROKE Study in Secondary Stroke Prevention https://www.bayer.com/en/us/news-stories/oceanic-stroke OAC-Naive Subgroup From OCEANIC-AF Published https://www.medscape.com/viewarticle/novel-blood-thinner-shows-promise-atrial-fibrillation-2025a10008lz GLP-1 and Myotrophic Drugs Lilly's Next-gen Drug Shows Greater Weight Loss Than Zepbound in Late-stage Trial (TRIUMPH-4) https://www.medscape.com/s/viewarticle/lillys-next-gen-drug-tops-zepbound-weight-loss-late-stage-2025a1000ys1 Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf CRISPR and Lipid Lowering Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease https://www.nejm.org/doi/full/10.1056/NEJMoa2504747 Gene Therapy Shows Lipid Improvement but Raises Flags https://www.medscape.com/viewarticle/gene-therapy-shows-lipid-improvement-raises-flags-2025a1000uzw Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 https://www.nejm.org/doi/full/10.1056/NEJMoa2511778 Evolocumab in Patients without a Previous Myocardial Infarction or Stroke (VESALIUS-CV) https://www.nejm.org/doi/pdf/10.1056/NEJMoa2514428 Prehospital GLP IIb/IIIa Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction (CELEBRATE) https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500268 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Cardiologist and author Eric Topol discusses the science of longevity, why the key to healthy aging is prevention, and the perils of a fixation on reversing ageing. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Super Agers: An Evidence-Based Approach to Longevity https://www.simonandschuster.com/books/Super-Agers/Eric-Topol/9781668067666 Wellderly study https://www.scripps.edu/science-and-medicine/translational-institute/translational-research/genomic-medicine/wellderly/ Lotte Bjerre Knudsen https://erictopol.substack.com/p/lotte-bjerre-knudsen-the-scientist Organ aging signatures in the plasma proteome track health and disease https://doi.org/10.1038/s41586-023- Deep Medicine https://drerictopol.com/portfolio/deep-medicine/ You may also like: Hear John Mandrola, MD, give a summary and his perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Bob Harrington chairs a panel with two early-career physician researchers and the head of a large research institute on what the future holds in lights of NIH funding cuts. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

A panel discussion of a Presidential Advisory from the American Heart Association that outlines the importance of funding for scientific research and the need for a robust National Institutes of Health. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington INCLUDE URLS and full titles for some of the pertinent studies cited. You may also like: Principles for the Future of Biomedical Research in the United States and Optimizing the National Institutes of Health: A Presidential Advisory From the American Heart Association https://doi.org/10.1161/cir.0000000000001319 The Role of Public-Sector Research in the Discovery of Drugs and Vaccines." https://www.nejm.org/doi/full/10.1056/NEJMsa1008268 Comparison of Research Spending on New Drug Approvals by the National Institutes of Health vs the Pharmaceutical Industry, 2010-2019 https://pubmed.ncbi.nlm.nih.gov/37115539/ Hear John Mandrola, MD's summary and perspective on the top cardiology news each week on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

A review paper prompted a discussion among cardiologists Bob Harrington, Manesh Patel, and Michael Gibson on whether the ST-segment elevation myocardial infarction paradigm needs an update. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction https://doi.org/10.1016/j.jacadv.2024.101314 Angiographic and Clinical Outcomes Among Patients With Acute Coronary Syndromes Presenting With Isolated Anterior ST-Segment Depression: A TRITON-TIMI 38 Substudy https://doi.org/10.1016/j.jcin.2010.05.012 Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021 https://jamanetwork.com/journals/jama/fullarticle/2798440 Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach https://doi.org/10.1016/j.ijcard.2021.11.039 Implantable Cardiac Alert System for Early Recognition of ST-Segment Elevation Myocardial Infarction https://doi.org/10.1016/j.jacc.2019.01.014 TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis https://doi.org/10.1161/CIRCRESAHA.117.311466 Early Versus Delayed Invasive Intervention in Acute Coronary Syndromes https://www.nejm.org/doi/full/10.1056/NEJMoa0807986 Translating AI for the Clinician https://doi.org/10.1001/jama.2024.21772 A Novel Breakthrough in Wrist-Worn Transdermal Troponin-I-Sensor Assessment for Acute Myocardial Infarction https://doi.org/10.1093/ehjdh/ztad015 A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI (CELEBRATE) https://clinicaltrials.gov/study/NCT04825743 Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (SOS-AMI) https://clinicaltrials.gov/study/NCT04957719 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Dr Bob Harrington interviews journalist Shelley Wood about her new book, "The Leap Year Gene of Kit McKinley," her creative process, and the difference between medical journalism and writing fiction. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington The Leap Year Gene of Kit McKinley https://shelleywood.ca/the-leap-year-gene/ Tragedy and Hope Wrapped in a Medical Mystery: Abraham Verghese and The Covenant of Water https://www.medscape.com/viewarticle/991751 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Bob Harrington and Mitch Elkind discuss "food is medicine" initiatives and the challenges associated with conducting clinical trials. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Health Care by Food Initiative https://healthcarexfood.org/ 2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association https://doi.org/10.1161/CIR.0000000000001031 Rockefeller Foundation Food is Medicine https://www.rockefellerfoundation.org/initiative/food-is-medicine/ Targeted Scientific Research Projects to Demonstrate Effectiveness of 'Food Is Medicine' in Health Care https://newsroom.heart.org/news/targeted-scientific-research-projects-to-demonstrate-effectiveness-of-food-is-medicine-in-health-care Food Is Medicine: A Presidential Advisory From the American Heart Association https://doi.org/10.1161/CIR.0000000000001182 Medically Tailored Meal Delivery for Diabetes Patients With Food Insecurity: a Randomized Cross-over Trial https://doi.org/10.1007/s11606-018-4716-z 'Food Is Medicine' Strategies for Nutrition Security and Cardiometabolic Health Equity: JACC State-of-the-Art Review https://doi.org/10.1016/j.jacc.2023.12.023 Current Landscape of Produce Prescription Programs in the US https://doi.org/10.1016/j.jneb.2022.02.011 Behavioral Nudges Are Used Widely to Steer Clinicians and Patients Alike https://doi.org/10.1056/CAT.23.0125 A Primary Care Agenda for Brain Health: A Scientific Statement From the American Heart Association https://www.ahajournals.org/doi/10.1161/STR.0000000000000367# You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Cardiology researchers Bob Harrington and Bobby Yeh discuss how to do better observational research and the controversial notion of making causal inferences from such data. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Academic Cardiology and Social Media https://doi.org/10.1161/CIRCOUTCOMES.118.004736 Bringing the Credibility Revolution to Observational Research and Cardiology https://doi.org/10.1161/CIRCULATIONAHA.123.064645 Cardio Twitter: An Essential Tool for Staying Current https://www.medscape.com/viewarticle/897512 Identification of Causal Effects Using Instrumental Variables https://doi.org/10.2307/2291629 Explaining Charter School Effectiveness https://www.aeaweb.org/articles?id=10.1257/app.5.4.1 Methods of Public Health Research - Strengthening Causal Inference from Observational Data https://doi.org/10.1056/NEJMp2113319 Publish or Perish and the Incentive for Quantity over Quality Research Papers https://www.medscape.com/viewarticle/998417 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Bob Harrington and Mike Gibson discuss two of the hottest topics in cardiology and medicine for 2023: a proposed alternative to the maintenance of certification process, and artificial intelligence. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Cardiovascular Organizations Pursue New, Independent Medical Board https://www.acc.org/About-ACC/Press-Releases/2023/09/21/15/02/Cardiovascular-Organizations-Pursue-New-Independent-Medical-Board The National Board of Physicians and Surgeons https://nbpas.org/ Level of Scientific Evidence Underlying the Current American College of Cardiology/American Heart Association Clinical Practice Guidelines https://doi.org/10.1161/CIRCOUTCOMES.118.005293 Validation of a Speech Analysis Application to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients https://www.abstractsonline.com/pp8/?_ga=2.17782015.7532578.1693882428-1949139275.1663003561#!/10871/presentation/16568 A systematic review shows no performance benefit of machine learning over logistic regression for clinical prediction models https://doi.org/10.1016/j.jclinepi.2019.02.004 Recognizing a ruler instead of a cancer https://menloml.com/2020/01/11/recognizing-a-ruler-instead-of-a-cancer/ The Geographic Bias in Medical AI Tools https://hai.stanford.edu/news/geographic-bias-medical-ai-tools You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Bob Harrington and Manesh Patel discuss sudden cardiac death in athletes and the importance of the chain of survival. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington COVID and the Athlete's Heart https://www.medscape.com/viewarticle/945282 Outcomes Registry for Cardiac Conditions in Athletes https://doi.org/10.1161/JAHA.122.029052 2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy https://doi.org/10.1161/CIR.0000000000000937 Point-of-care screening for HFrEF using artificial intelligence during ECG-enabled stethoscope examination https://doi.org/10.1016/s2589-7500(21)00256-9 International recommendations for electrocardiographic interpretation in athletes https://doi.org/10.1093/eurheartj/ehw631 Elevation of Cardiac Troponins After Endurance Running Competitions https://doi.org/10.1161/CIRCULATIONAHA.118.034655 Vigorous Exercise in Patients With Hypertrophic Cardiomyopathy https://doi.org/10.1001/jamacardio.2023.1042 Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble, Principles, and General Considerations https://doi.org/10.1161/CIR.0000000000000236 RACE-CARS Trial https://racecarstrial.org/ AHA CPR Resources https://cpr.heart.org/en/cpr-courses-and-kits/hands-only-cpr You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Robert Harrington, MD and Jenine John, a cardiologist and machine learning research fellow discuss what you need to know about AI and ML in healthcare and where to find some helpful resources. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington 'One Brave Idea' Recipient on Predicting Who Will Develop CAD https://www.medscape.com/viewarticle/874536 Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection https://doi.org/10.1161/circulationaha.121.058696 Application of Artificial Intelligence to the Electrocardiogram https://doi.org/10.1093/eurheartj/ehab649 Using Machine Learning to Detect Problems in ECG Data Collection https://www.cinc.org/archives/2011/pdf/0437.pdf Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs https://doi.org/10.1161/CIRCEP.119.007284 External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients http://jamanetwork.com/article.aspx?doi=10.1001/jamainternmed.2021.2626 Sepsis Predictor Tool Falls Short in Emergency Setting https://www.medscape.com/viewarticle/982534 Dissecting Racial Bias in an Algorithm Used to Manage the Health of Populations https://doi.org/10.1126/science.aax2342 Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms https://jamanetwork.com/journals/jama/fullarticle/2770833 Can Medical Algorithms Be Fair? Three Ethical Quandaries and One Dilemma https://doi.org/10.1136/bmjhci-2021-100445 Healthcare Machine Learning: Getting Started https://medium.com/@jeninej/healthcare-machine-learning-getting-started-761a7dbb63a2 What Clinicians Should Know About Healthcare AI, Part 1: Why Care About AI? https://medium.com/@jeninej/what-clinicians-should-know-about-healthcare-ai-part-1-why-care-about-ai-aba6a06f696d AI in Healthcare Specialization https://www.coursera.org/specializations/ai-healthcare You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine: https://www.medscape.com/features/public/machine Hear John Mandrola, MD's, summary and perspective on the top cardiology news each week, on This Week in Cardiology: https://www.medscape.com/twic Questions or feedback, please contact: news@medscape.net