The Kidney Chronicles: A Pediatric Nephrology Podcast

In this episode we speak to Dr. Hiep Nguyen a pediatric urologist at Banner Children’s Hospital on urinary tract dilation, a topic that while common is often poorly understood. He explains the pathophysiology of physiologic urinary tract dilation and discusses the risks associated with the various grades of urinary tract dilation. References Nguyen HT, Benson CB, Bromley B, Campbell JB, Chow J, Coleman B, Cooper C, Crino J, Darge K, Herndon CD, Odibo AO, Somers MJ, Stein DR. Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system). J Pediatr Urol. 2014 Dec;10(6):982-98. doi: 10.1016/j.jpurol.2014.10.002. Epub 2014 Nov 15. PMID: 25435247.

Join us for Part 2 as we discuss the management of pediatric chronic hemodialysis and troubleshooting common complications. Guest experts include: Dr. Cherry Mammen, Assistant Professor and Dialysis Director at British Columbia Children's Hospital, Dr. Raj Munshi, Associate Professor and Dialysis Director at Seattle Children's, and Dr. Sarah Swartz, Associate Professor and Dialysis Director at Texas Children's.

Dr. Molly Vega, RD and PhD at Texas Children's and Nonnie Polderman, RD at British Columbia Children's Hospital provide their expertise on pediatric dialysis nutrition considerations, specifically in the realms of acute kidney injury and CRRT. -Visit https://www.espn-online.org/nutrition-taskforce/ to see the clinical practice guidelines published by the Paediatric Renal Nutrition Taskforce

Dr. Carla Nester, Professor of Pediatrics and Internal Medicine and Division Director of Pediatric Nephrology as well as the Associate Director of Molecular Otolaryngology and Renal Research Laboratory at the University of Iowa and international expert in Complement Disorders, discusses atypical HUS. She reviews the pathophysiology, clinical presentation, evaluation, management and transplant considerations.

In this first episode of our two part series on pediatric hypertension, we talk to Dr. Tammy Brady, a pediatric nephrologist at Johns Hopkins, and Dr. Joshua Samuels, both a pediatric and adult nephrologist at University of Texas Houston. In this episode they review ambulatory blood pressure monitors, the basis for our standards for diagnosing pediatric hypertension, the pathophysiology behind obesity increasing the risk of developing hypertension, and ensuring blood pressure is accurately measured.

In this episode of the podcast we focus on recurrent urinary tract infections, looking at how we diagnose UTIs, the diagnostic challenges, the causes of recurrent UTIs, and the management. We interview Dr. John David Spencer the division chief of pediatric nephrology at Nationwide Children's Hospital and Dr. David Hains the division chief of pediatric nephrology at Riley Children's Hospital who are both experts on the topic with extensive research into this arena and numerous publications. Marsh MC, Junquera GY, Stonebrook E, Spencer JD, Watson JR. Urinary Tract Infections in Children. Pediatr Rev. 2024 May 1;45(5):260-270. doi: 10.1542/pir.2023-006017. PMID: 38689106. Hains DS, Starr MC, Schwaderer AL. Glomerular Filtration Rate Changes Following UTI in Children With Vesicoureteral Reflux. JAMA Pediatr. 2024 Dec 1;178(12):1366-1368. doi: 10.1001/jamapediatrics.2024.4546. PMID: 39446735; PMCID: PMC11581724.

Dr. Maria Diaz-Gonzalez de Ferris, MD, MPH, PhD, joins us for a conversation about her approach to transitions of care in Nephrology. She is a pediatric nephrologist at UNC Chapel Hill, the Director of the UNC Transition Program otherwise known as STARx. Through her research work focusing on healthcare transitions for children with medical complexity, she has developed a system of healthcare checkpoints and resources that assess autonomy and self-management. In this episode, we briefly discuss the importance of transitions of care, general guidelines and resources, approaches in specialized populations such as transplant/CKD/ESRD, and resources that are available to those interested in optimizing their local transitions of care infrastructure. Resources: National and International Guidelines International Pediatric Nephrology Association (IPNA): https://pubmed.ncbi.nlm.nih.gov/21832978/ AAP/AAFP/ACP Healthcare Transition Guidelines (for general health care transitions and transfer): https://publications.aap.org/pediatrics/article/142/5/e20182587/38577/Supporting-the-Health-Care-Transition-From Got Transition (online resource for general transitions of care): https://www.gottransition.org/ STARx Program Description: https://www.med.unc.edu/transition/about-us-1/ STARx Transition Tools (Healthcare passport, All you need is love transition syllabus, Transition Index readiness assessment, STARx questionnaire): https://www.med.unc.edu/transition/transition-tools/

For this episode on ARPKD interviewed Dr. Lisa Guay-Woodford a clinician scientist at Children’s Hospital of Philadelphia who is a world-renowned expert on cystic kidney diseases. She was part of one of the teams that discovered the ARPKD gene and provides fascinating insight into the history and management of the condition. References ARPKD genetic variations: https://www.sciencedirect.com/science/article/abs/pii/S1096719209002947 Bilateral nephrectomy outcomes: https://www.nature.com/articles/s41598-020-71956-1

Dr. Matthew Sampson, a pediatric nephrologist and associate professor of pediatrics at Harvard Medical School, walks us through genetic testing for pediatric patients with kidney disease. He discusses indications for genetic testing and how to interpret results. He also talks about his lab and work as a genomics researcher. Episode References Sampson Lab: https://www.sampsonlab.org/ ClinVar: https://www.ncbi.nlm.nih.gov/clinvar/ KDIGO genetic testing guidelines: https://kdigo.org/wp-content/uploads/2022/05/KDIGO-Genetics-in-CKD-Conference-Report-Corrected-Proof.pdf NKF genetic testing guidelines: https://www.ajkd.org/article/S0272-6386(24)00871-0/fulltext CJASN Genomics of Kidney Disease Series: https://journals.lww.com/CJASN/Documents/collections/kidney.pdf

Join us for a journal-style episode covering 2023 CJASN article, "Timing of Kidney Replacement Therapy among Children and Young Adults." Drs. Nick Larkins and Simon Carter discuss the findings from the Australia and New Zealand Dialysis and Transplant Registry and compare and contrast it to United States, Canada and European data. Article link: https://pubmed.ncbi.nlm.nih.gov/37279903/

Join us to learn about hyperoxaluria from nephrolithiasis expert and division director of pediatric nephrology at Mayo Clinic, Dr. David Sas! We discuss pathophysiology, work-up and management of primary hyperoxaluria, including new game-changing therapies. Dr. Sas also answers other high-yield kidney stone management questions. Resources: Novodetect primary hyperoxaluria/nephrolithiasis genetic panel testing: file:///Users/student/Downloads/BpG_GTP-for-NovoDetect-Panels-Form_GTP-NVDT-2P-B.pdf Rare Kidney Stone Consortium (RKSC): 800-270-4637 or rarekidneystones@mayo.edu Resources for physicians and patients regarding all forms of rare kidney stone diseases Oxalosis and Hyperoxaluria Foundation (OHF): www.ohf.org Resources for patients, parents, and physicians regarding primary hyperoxaluria

Drs. Donna Claes, Vivian Shih and Annie Kouri (our co-host) discuss their roles as pediatric dialysis directors at their institutions. Donna Claes is an associate professor of pediatric nephrology and chronic dialysis director at Cincinnati Children's and Vivian Shih is an assistant professor of pediatric nephrology and acute dialysis director at Children's Hospital Colorado. We talk about the road to becoming a dialysis director, what the job entails, the challenges, the rewarding aspects of the job and tips for those who are considering stepping into this position at their institution.