The Male Room with Dr. Jesse Mills

Dr. Mills sits down with internationally acclaimed DJ, licensed therapist, and host of the iHeart podcast Music Is Therapy, DJ Hesta Prynn, to explore the surprising science behind music, mindset, and emotional health. From learning vinyl from Questlove to developing her “music connection therapy,” she breaks down how the right song can literally rewire your brain—and change how you show up in the world. The conversation moves from rage-fueled pump-up anthems to deeply personal playlists, touching on everything from chronic pain to creative fulfillment. It’s a wide-ranging, high-energy look at how music can be more than entertainment—it can be medicine.See omnystudio.com/listener for privacy information.

Every guy wants to keep his hair—but not at the expense of everything else. Dr. Mills unpacks finasteride, its benefits, and the rare but real side effects that have fueled online panic around post-finasteride syndrome. Along the way: hormone deep-dives, myth-busting, and why “one-size-fits-all” medicine doesn’t work. It’s the truth about hair loss drugs—without the fear-mongeringSee omnystudio.com/listener for privacy information.

In Part 2 of our vasectomy series, Dr. Jesse Mills and Dr. Jay Sandlow dive into what happens when “permanent” birth control isn’t so permanent—breaking down the science, success factors, and surprising complexities of vasectomy reversals. From the difference between surgical techniques to the real-world variables that impact fertility—including partner age, prior history, and timing—they walk through what couples need to know when considering their options. Along the way, the conversation veers into jaw-dropping patient stories, common myths, and the emotional, ethical, and human realities behind these deeply personal decisions. It’s an honest, fascinating look at modern fertility medicine—and the second chances it can offer.See omnystudio.com/listener for privacy information.

Dr. Mills walks listeners through what life after prostate cancer surgery can really look like, with a candid focus on sexual recovery, continence, and quality of life. He explains how “prehab” — including medication, pelvic floor exercises, nutrition, and follow-up care — can help men improve their odds of regaining function after treatment. Along the way, Dr. Mills and Jordan discuss the emotional vulnerability that comes with prostate cancer recovery, breaking down the fears, myths, and real-world concerns men and their partners often face. It’s an honest, practical, and compassionate conversation about surviving cancer without giving up on intimacy, confidence, or hope.See omnystudio.com/listener for privacy information.

In the third and final installment of our prostate-cancer trilogy with UCLA urologic oncologist Dr. Wayne Brisbane, Dr. Mills walks a 55-year-old patient through the modern treatment menu—active surveillance, focal therapy, surgery, and radiation—and why “having prostate cancer” doesn’t always mean “operate immediately.” Dr. Brisbane breaks down how doctors risk-stratify tumors (including what Gleason scores really mean), why PSA “ups and downs” can trigger anxiety, and how newer tools (from genomic tests to MRI-guided radiation) help personalize decisions. They also get real about side effects and recovery, from muscle-sparing prostatectomy techniques that can speed urinary control to the “sunburn in the bladder” sensations some men feel after radiation. The takeaway: treat the cancer the way it’s asking to be treated—and don’t be afraid to slow down, get second opinions, and choose the option that best matches your life.See omnystudio.com/listener for privacy information.

In the first episode of our three-part Prostate Cancer series, Dr. Jesse Mills and Jordan Runtagh sit down with UCLA urologic oncologist and surgeon-scientist Dr. Wayne Brisbane to tackle the most confusing—and most important—starting point: screening. What does an “elevated PSA” actually mean, why is it controversial, and how do you avoid unnecessary panic (or unnecessary procedures) while still catching cancer early? Using a real-world “55-year-old patient journey,” they break down PSA as a prostate “thermometer,” when to repeat a test, what role MRI plays today, and how newer tools like urine biomarkers and micro-ultrasound are reshaping early detection—before the series moves on to diagnosis and treatment. See omnystudio.com/listener for privacy information.

Dr. Mills sits down with hormone therapy physician and entrepreneur Dr. Peter Fotinos to unpack the difference between “hormone replacement” and true hormone optimization. They dig into how studies like the Women’s Health Initiative shaped decades of fear, and why symptoms and lived experience sometimes matter more than a single lab cutoff. The conversation also tackles common pitfalls of “testosterone mill” medicine (including routine aromatase inhibitors), plus what’s changing in women’s hormone care and why testosterone matters for women beyond libido. Finally, Dr. Fotinos shares how he’s scaling more responsible, check-in-driven telehealth—and what proactive medicine can look like for the everyday guy staring down metabolic syndrome.See omnystudio.com/listener for privacy information.

Dr. Mills is joined by celebrity nutritionist and gut-health expert Dr. Daryl Gioffre to break down what’s really driving America’s acid reflux epidemic—and why the root cause is often too little stomach acid, not too much. After revealing the deeply personal story that pushed him into this work following his father’s battle with esophageal cancer, Dr. Gioffre shares practical strategies to support digestion and protect the esophagus — from the “three-hour rule” before bed to simple soothing tools like teas, honey, and magnesium. The conversation also gets into why sugar is so hard to quit, how ultra-processed foods (and “gluten-free” swaps) can backfire, and how to make realistic upgrades without white-knuckling your way through life—including how you might keep your coffee and calm your gut.See omnystudio.com/listener for privacy information.

As the New Year begins, it’s the perfect time to take stock — not just of your physical health, but your mental one, too. Dr. Mills kicks off the year by welcoming renowned therapist Dr. Steve Poulter. Together, they explore modern masculinity, shame, isolation, and what it really means for men to be emotionally resilient. Drawing on decades of clinical experience — and a remarkable life path that included stints in law enforcement and the seminary — Dr. Poulter offers practical tools for growth, accountability, and connection. See omnystudio.com/listener for privacy information.

Urologist and informatics leader Dr. Denise Asafu-Adjei joins Dr. Mills to break down how AI is quietly transforming men’s health, from AI-powered scribes that free doctors to actually look patients in the eye to chatbots that could triage symptoms and streamline access to care. They dig into the big questions patients (and physicians) are asking right now: privacy, accuracy, and whether technology will ease burnout or simply fill every last “free” minute on the schedule. Plus, Dr. Denise (@drdenise_official) shares where the field is heading next — including mind-blowing fertility advances like AI-assisted sperm identification — and what it’ll take (education, policy, and better data sharing) to make the future of medicine both smarter and more human.See omnystudio.com/listener for privacy information.

This week, Dr. Jesse Mills is joined by Dr. Jasper Bash — men’s health expert, researcher, and occasional a cappella tenor — for a candid look at how to build healthier sperm. They unpack the latest findings on marijuana, alcohol, and other environmental exposures, including what’s myth, what’s real, and what’s actually reversible. Dr. Bash also shares practical timelines, clinical tips, and the fitness and nutrition habits that keep him performing at his best.  See omnystudio.com/listener for privacy information.

In part two of The Male Room’s deep dive on low testosterone, Dr. Jesse Mills and Jordan shift from diagnosis to what everyone really wants to know: treatment. Dr. Mills walks through the major options — gels, pills, injections, and long-acting pellets — breaking down how they work, who they’re best for, and how to choose a provider who’s not just pushing the product of choice. He explains when testosterone therapy truly makes sense, what happens if you over-treat, how and why it can act as male birth control, and the safest ways to come off therapy if you want to start a family or reboot your natural production. Along the way, he busts some of the biggest myths around “T boosters” and “roid rage,” and lays out the lifestyle levers — sleep, exercise, weight loss — that can raise levels naturally. It’s an empowering, no-BS guide designed to help guys ask smarter questions, avoid bad clinics, and use testosterone as one tool (and not a magic fix) in taking control of their health.See omnystudio.com/listener for privacy information.

In the debut episode of The Male Room, Jordan the Producer makes a confession that stops Dr. Mills in his tracks: he hasn’t had a full physical in nearly a decade. What starts as a sheepish admission quickly turns into a bigger conversation about modern men and medical avoidance — why so many guys skip routine checkups and how often you really need to see a doctor. Dr. Mills breaks down the guidelines with his trademark mix of clarity and humor, debunking a few myths along the way and explaining why “I feel fine” isn’t a health plan. It’s a funny, relatable, occasionally humbling kickoff to the series — and the answer to “How often should men go to the doctor?” might genuinely surprise you.See omnystudio.com/listener for privacy information.