Ep. 313: “Cardiovascular Disease Mechanisms” Featuring Dr. Joseph Wu

About this episode

Dr. Joseph Wu discusses cardiovascular disease mechanisms and the role of pharmacology in drug discovery.

Guest: Dr. Joseph Wu is a Professor of Medicine and Radiology and the Director of the Stanford Cardiovascular Institute. He talks about the importance of pharmacology knowledge in drug discovery. He also discusses his early iPSC research, investigating vaccine-induced myocarditis , and embracing New Approach Methodologies (NAMs) . (39:40) Featured Products and Resources: Submit your abstract for ISSCR 2026 by February 25th! STEMdiff™ Ventricular Cardiomyocyte Differentiation Kit The Stem Cell Science Round Up Autism Genes in Organoids: Research provides new insight into the convergent impact of autism spectrum disorder genetic risk on human neurodevelopment. (2:35) Pancreatic Organoid Screening: High-content screen reveals 54 compounds altering pancreatic organoid shape or differentiation. (13:15) CRISPR Screening for Tauopathies: CRISPR screens in human neurons reveal modifiers of tau oligomer accumulation. (21:03) Fixing Facial Scarring: Modulating ROBO2-EID1-EP300 signaling pathway promotes facial-like reduced fibrosis at scar-prone sites. (31:00) Image courtesy of Dr. Joseph Wu Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

People in this episode

Guest: Dr. Joseph Wu

Topics covered

• Cardiovascular Disease
• Pharmacology
• Drug Discovery
• iPSC Research
• Vaccine-induced Myocarditis
• New Approach Methodologies

Keywords

• Cardiovascular Disease
• Pharmacology
• Drug Discovery
• iPSC
• Myocarditis
• NAMs
• CRISPR
• Organoids

Mentioned in this episode

Organizations: Stanford Cardiovascular Institute

Products: STEMdiff™ Ventricular Cardiomyocyte Differentiation Kit

Books & works: Autism Genes in Organoids, Pancreatic Organoid Screening, CRISPR Screening for Tauopathies, Fixing Facial Scarring

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