Ep. 315: “Advanced Stem Cell-Based Models” Featuring Drs. Shuibing Chen and Hans Clevers

About this episode

Drs. Shuibing Chen and Hans Clevers discuss the integration of stem cell-derived models into drug development and the importance of regulatory standards.

Guest: Drs. Shuibing Chen and Hans Clevers, members of the Steering Committee for the ISSCR Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development , discuss the need to accelerate the responsible integration of stem cell–derived models into preclinical drug development. Their conversation reflects growing regulatory and policy momentum around new approach methodologies (NAMs) and underscores the importance of rigorous standards, regulatory alignment, and cross-sector collaboration to improve reproducibility and advance more predictive, human-relevant therapies. Building on its long-standing leadership in global standards, ethics, and policy, the ISSCR is uniquely positioned to convene industry, academia, and regulators around this effort. The initiative also reflects the Society’s expanding industry engagement, with industry membership increasing nearly 180% over the past five years – creating new opportunities for strategic partnerships to address shared scientific and translational challenges. Featured Products and Resources: Learn how organoids can be used to expand clinical applications of diseases and disorders. Get a free wallchart showing how…

People in this episode

Host: The Stem Cell Podcast

Guests: Drs. Shuibing Chen, Hans Clevers

Topics covered

• stem cell models
• drug discovery
• preclinical development
• regulatory alignment
• cross-sector collaboration

Keywords

• stem cells
• drug development
• preclinical models
• NAMs
• regulatory standards
• organoids
• clinical applications

Mentioned in this episode

Organizations: ISSCR Consortium, ISSCR

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