Trying to Conceive with Dr. Sasha Hakman

What happens when you're the picture of health, crushing it in your career, and then find out you can't get your partner pregnant? In this episode, I sit down with Brian Mazza, entrepreneur, founder of High Performance Lifestyle Training, and one of the few men openly talking about male infertility. Brian shares his deeply personal journey from receiving devastating test results to navigating IVF, relationship strain, and ultimately becoming a father to two boys through ICSI. We talk about the moment he found out about his low sperm count, motility, and morphology, and how that diagnosis made him feel like a failure despite being in incredible shape. Brian opens up about the shame, the embarrassment, and the defensiveness that came with being told he was the reason they couldn't conceive naturally. He also shares how it nearly broke his marriage, the moment he offered his wife a divorce so she could have kids with someone else, and the turning point that brought them back together. This conversation goes beyond the medical side of infertility. We dive into the emotional toll on men, the lack of conversation around male factor infertility, and why so many guys suffer in silence. Brian explains why he decided to go public with his story, how he raised over $80,000 by running 50 miles from Cornell to his home, and why he believes every man should get tested early and often. We also talk about fatherhood, what it means to show up for your kids every single day, and why Brian has made a personal pledge to never let his sons see him tired or drink alcohol. His approach to parenting is rooted in presence, discipline, and leading by example, and it's clear that his infertility journey shaped the father he is today. If you're a man navigating infertility, a woman supporting a partner through it, or anyone who wants to understand the male perspective on fertility struggles, this episode will give you insight, hope, and a reminder that infertility does not define your masculinity or your ability to be an incredible parent. Brian's story is proof that with the right medical care, emotional resilience, and a strong partnership, you can get through this and come out the other side with everything you've been hoping for. _____ Follow Brian Mazza on Instagram: @brianmazzaHigh Performance Lifestyle Training: @hpltraining Follow Dr Sasha!TikTok: @sashahakmanmdInstagram: @sashahakmanmd @tryingtoconceivepodYouTube: @tryingtoconceivepod Want to receive my weekly newsletter? Sign up at sashahakmanmd.com/newsletter to receive updates, answers to Q&A and more!If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every 2 weeks.If you're interested in becoming a patient go to sashahakmanmd.com to learn more! Learn more about your ad choices. Visit megaphone.fm/adchoices

Can you really get pregnant after seven failed embryo transfers? What does it take to keep going when nothing seems to work? In this episode, I sit down with Abbe Feder to talk about one of the most intense fertility journeys I’ve ever heard. After 6 years of trying to conceive, 8 embryo transfers, a miscarriage, an ectopic pregnancy, and multiple failed IVF cycles, Abby finally got her miracle… twins. But this conversation goes far beyond just the outcome. We break down what unexplained infertility actually means, why IVF doesn’t always work even when everything looks “perfect,” and the emotional toll that no one prepares you for. Abbe shares the mindset shifts that helped her keep going, the financial realities of fertility treatment, and the truth about resilience during infertility. We also talk about the hardest moments along the way, including pregnancy loss, the waiting, the uncertainty, and the constant cycle of hope and disappointment. Abbe now helps women navigate infertility through coaching, and her ability to put feelings into words will make you feel seen in a way that’s hard to explain. If you’re going through infertility, considering IVF, or supporting someone who is, this episode will change how you think about the journey. And if nothing else, I hope it reminds you that you’re not alone. Abbe Feder is a fertility coach and founder of Encircle Fertility. After experiencing 6 years of unexplained infertility, multiple IVF cycles, pregnancy loss, and ultimately having twins, Abbe now helps women navigate the emotional and mental challenges of infertility. Her work focuses on normalizing the experience and supporting women through one of the most difficult journeys of their lives.Follow Abbe Instagram: @abbefeder @encirclefertilityWebsite: https://www.incirclefertility.com_____Follow Dr Sasha!TikTok: @sashahakmanmdInstagram: @sashahakmanmd @tryingtoconceivepodYouTube: @tryingtoconceivepod If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every 2 weeks.If you're interested in becoming a patient go to sashahakmanmd.com to learn more! Learn more about your ad choices. Visit megaphone.fm/adchoices

Should you freeze your eggs? And if you do, how many do you actually need to feel confident about your future fertility? In this episode, Dr. Sasha Hakman sits down with Dr. Jessica Ryniec, a reproductive endocrinologist based in Boston, to break down everything you need to know about fertility preservation. From egg freezing to embryo banking, this conversation covers the science, the process, the myths, and the practical decisions that come with preserving your fertility. Dr. Ryniec explains why fertility preservation has become so popular, who should consider it, and how the process actually works from evaluation to egg retrieval. You'll learn what ovarian reserve testing really tells you, why AMH matters even if it doesn't predict pregnancy, and how age impacts both egg quality and quantity. They discuss the reality that egg quality declines over time due to DNA repair breakdown, and why waiting too long can significantly reduce your chances of success. This episode dives into the technical side of egg freezing, including how vitrification revolutionized the field, what happens in the lab once your eggs are retrieved. Dr. Ryniec shares her approach to counseling patients on how many eggs to freeze based on age and family goals, and why 70% chance of one live birth is often a comfortable target for many patients. They also tackle the debate between freezing eggs versus embryos in a committed relationship, and why most fertility doctors have done fertility preservation themselves. Dr. Ryniec discusses the role of AI in egg selection, the limitations of current technology, and why fertility preservation is better thought of as a head start rather than insurance. You'll also learn about priming protocols, how birth control pills and IUDs can temporarily suppress ovarian response, and why lifestyle factors like sleep, hydration, and movement matter more than extreme dietary restrictions. Dr. Ryniec shares her thoughts on when it's too old to freeze eggs, how to optimize egg health in the 90 days before a cycle, and why smoking and daily fast food are bigger concerns than occasional gluten or dairy. This episode is essential listening for anyone considering egg freezing, wondering if they should wait to optimize their health first, or trying to decide between eggs and embryos. Whether you're single, in a relationship, or simply want to understand your options, this conversation will give you the knowledge and confidence to make the right decision for your future family. _____ Follow Dr. Jessica Ryniec on Instagram and TikTok: @jessicaryniecmd Follow Dr Sasha! TikTok: @sashahakmanmd Instagram: @sashahakmanmd @tryingtoconceivepod YouTube: @tryingtoconceivepod Want to receive my weekly newsletter? Sign up at sashahakmanmd.com/newsletter to receive updates, answers to Q&A and more! If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every 2 weeks. If you're interested in becoming a patient go to sashahakmanmd.com to learn more! Learn more about your ad choices. Visit megaphone.fm/adchoices

Could your PCOS diagnosis actually be something else? In this episode of the Trying to Conceive Podcast, Dr. Sasha Hakman breaks down polycystic ovary syndrome (PCOS), one of the most common and misunderstood hormonal conditions affecting fertility. She also shares her personal experience of believing she had PCOS for years before discovering through expanded genetic testing that she actually had non-classical congenital adrenal hyperplasia (NCCAH), a condition that can closely mimic PCOS but requires different treatment. Dr. Hakman explains what PCOS really is, why it has nothing to do with ovarian cysts, and how it is properly diagnosed using the Rotterdam criteria. She also walks through the essential lab work needed to rule out other hormonal conditions, including thyroid disorders, elevated prolactin, adrenal disorders, and testosterone producing tumors. You will also learn why testing 17-hydroxyprogesterone is a critical step that is often missed. The episode explores how insulin resistance and elevated androgens drive many PCOS symptoms such as irregular periods, infertility, acne, and unwanted hair growth. Dr. Hakman also discusses the long term health risks associated with PCOS, including type 2 diabetes, metabolic syndrome, cardiovascular disease, and endometrial cancer. Finally, she covers evidence based treatment strategies, from lifestyle changes like nutrition and resistance training to medications and fertility treatments such as Letrozole. Whether you have been diagnosed with PCOS, suspect you might have it, or want to better understand hormonal and metabolic health, this episode provides a clear and practical guide to navigating this complex condition. _____ Follow Dr Sasha! TikTok: @sashahakmanmd Instagram: @sashahakmanmd @tryingtoconceivepod YouTube: @tryingtoconceivepod Want to receive my weekly newsletter? Sign up at sashahakmanmd.com/newsletter to receive updates, answers to Q&A and more! If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every 2 weeks. If you're interested in becoming a patient go to sashahakmanmd.com to learn more! Learn more about your ad choices. Visit megaphone.fm/adchoices

How many follicles are too many for an IUI? When should you move on to IVF? And is IUI ever a waste of time? In this episode, Dr. Sasha Hakman sits down with Dr. Blake Evans, a reproductive endocrinologist and researcher whose groundbreaking studies on ovarian stimulation and IUI have changed the way fertility specialists counsel patients every day. Dr. Evans breaks down his widely cited research on follicle count, multiples risk, and pregnancy rates across different age groups. He explains why singleton pregnancy rates stay the same whether you have one, two, three, or even five follicles, and why the only thing that increases with more follicles is the risk of multiples, especially in women under 38. We discuss the real risks of twin and triplet pregnancies, including preterm delivery, NICU stays, maternal complications, and the financial burden that can far exceed the cost of IVF itself. Dr. Evans also shares his second major study showing that patients can still conceive after multiple IUI cycles, with cumulative pregnancy rates reaching over 70% by cycle eight, though he emphasizes this does not mean it is the most efficient or cost effective path. This conversation is packed with practical takeaways for both patients and providers navigating unexplained infertility, insurance limitations, and the decision between continuing IUI or moving to IVF. Dr. Evans also shares candid insights on the Femeseed device, fresh transfers in IVF, and how geography and insurance coverage shape treatment decisions. If you are trying to decide how many IUI cycles to do, whether to cancel a cycle due to too many follicles, or if IVF is worth the investment, this episode will give you the data and clarity you need to move forward with confidence. _____ Follow Dr. Blake Evans on Instagram: @dr.blakeevans Follow me! TikTok: @sashahakmanmd Instagram: @sashahakmanmd @tryingtoconceivepod YouTube: @tryingtoconceivepod Want to receive my weekly newsletter? Sign up at sashahakmanmd.com/newsletter to receive updates, answers to Q&A and more! If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every 2 weeks. If you're interested in becoming a patient go to sashahakmanmd.com to learn more! Learn more about your ad choices. Visit megaphone.fm/adchoices

What if your fertility struggles are not just bad luck? In this episode, I sit down with Dr Natalie Crawford to unpack one of the most overlooked drivers of infertility… chronic inflammation. We talk about why so many women are told to “just try for 12 months” before testing, why sperm counts have dropped dramatically over the last 50 years, and how inflammation quietly interferes with ovulation, egg quality, sperm health, implantation and even IVF outcomes . Dr Crawford shares her personal story of experiencing multiple pregnancy losses while training as a fertility specialist and how digging into the research on inflammation changed everything for her. From discovering a short luteal phase to eventually being diagnosed with celiac disease, she explains how lifestyle changes and reducing inflammatory burden impacted her own fertility journey . If you are doing everything “right” but still not getting pregnant, this episode will give you a deeper understanding of what may be happening at the cellular level and how to proactively support your reproductive health. _____ We cover: • How chronic inflammation disrupts the brain to ovary communication pathway • The connection between stress, cortisol and insulin resistance • Why egg quality is not only about age • How skeletal muscle improves insulin sensitivity and fertility • Why sleep is foundational for hormone balance • The gut microbiome, estrogen metabolism and intestinal permeability • Red meat, ultra processed foods and IVF outcomes • Environmental toxins and endocrine disruptors in daily life • What to optimize 90 days before IVF _____ Fertility is not just about biology. It is a health marker. And you deserve to understand how your daily choices add up. If you found this helpful, make sure to subscribe, leave a review, and share with someone who is trying to conceive. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this solo Q&A episode, Dr. Sasha Hakman answers your most common and complex fertility questions with clarity and nuance. She breaks down topics like chronic endometritis and transfer timing, reasons for low egg maturity and fertilization rates, day 7 PGT-normal embryos, and what “normal” HCG rises really look like. Dr. Hakman also shares guidance on natural vs. programmed FETs, exercising during IVF and transfers, protocols for low AMH and diminished ovarian reserve, vaginal microbiome testing, and when to pursue fertility evaluation—even after having children. This episode is packed with practical insights to help you make informed, confident decisions throughout your fertility journey. Learn more about your ad choices. Visit megaphone.fm/adchoices

Our latest episode is here, and it’s one every fertility patient should hear. Dr. Sasha Hakman sits down with Certified Genetic Counselor Meaghan Doyle to break down the confusion around PGT-A, embryo grading, and what mosaic results really mean. In this conversation, Meaghan explains the differences between euploid, aneuploid, and mosaic embryos, why so many early embryos show mosaicism, and how to think about transferring a mosaic when it’s your only option. They also discuss the limitations of PGT-A, when it’s helpful, and why results should always be interpreted within the full clinical picture. If you’ve ever wondered whether PGT-A is worth it—or whether viable embryos are being discarded based on testing alone—this episode brings clarity, nuance, and evidence-based guidance. Listen now to feel more informed and empowered on your fertility journey. Learn more about your ad choices. Visit megaphone.fm/adchoices

Artificial intelligence is revolutionizing reproductive medicine. In this episode, Dr. Sasha Hakman sits down with Dr. Eduardo Hariton—Harvard-trained OB-GYN, reproductive endocrinologist, and innovation leader at US Fertility—to explore how AI is transforming every stage of fertility care. From personalizing IVF medication protocols to improving embryo selection and patient communication, Dr. Hariton shares how technology is enhancing outcomes, increasing accessibility, and allowing doctors to focus on what truly matters: caring for patients on their path to parenthood. Learn more about your ad choices. Visit megaphone.fm/adchoices

For anyone tracking ovulation, this episode is a must-listen. Dr. Sasha Hakman and Dr. Pero from Inito dive into the real science behind fertility monitoring—how to know when you’re actually fertile, what hormonal patterns really matter, and why one-size-fits-all apps don’t cut it. Hear how Inito’s technology is redefining what it means to be informed and empowered while trying to conceive. Get your Inito for $89 with the code TTCPODCAST https://try.inito.com/hormone-tracking/inf/?discount=TTCPODCAST&utm_source=social_media&utm_medium=social&utm_campaign=podcast&utm_content=TTCPODCAST Learn more about your ad choices. Visit megaphone.fm/adchoices

In this solo episode, Dr. Sasha Hakman dives deep into one of the most frustrating diagnoses in reproductive medicine: unexplained infertility. She breaks down what it really means when everything looks “normal” on paper—but pregnancy still isn’t happening. From testing protocols to treatment options like IUI and IVF, this episode is your go-to guide for understanding how to navigate the unknown and how to move forward with confidence. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, longevity leader and wellness entrepreneur Kayla Barnes joins Dr. Sasha Hakman to share her science-backed approach to fertility preservation. Kayla touches on how she decided to freeze eggs vs embryos and the tools she used that helped her recover faster than any patient Dr. Hakman has seen, Kayla breaks down the why, how, and what’s next in her journey to building a big family. Expect tips on testing, mindset, and why optimizing health before conception might be the most powerful investment of all. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Sarah Oreck- psychiatrist, mother of three, and co-founder of Mavida Health- opens up about her experience with second trimester loss, IVF, and the emotional complexity of trying to conceive. With Dr. Sasha Hakman, she discusses how mental health is often overlooked in fertility treatment, the stigma around termination for medical reasons, and how her personal story helped shape the way she cares for others. This is an honest conversation about what it means to choose your path and how to survive when things don’t go as planned. Learn more about your ad choices. Visit megaphone.fm/adchoices