Up One

In this episode of Up One, hosts Sawyer Stone and Dr. Bill Andrews are joined by world-renowned sexual health expert Dr. Amy Killen to explore the profound link between physical intimacy and biological longevity. The conversation breaks down the "four pillars" of sexual health—the mind, hormones, blood flow, and pelvic support—while highlighting research that suggests regular sexual activity can lower all-cause mortality by 50%. From the benefits of oxytocin and nitric oxide to emerging regenerative treatments like shockwave therapy and stem cells, the trio discusses how maintaining sexual vitality isn't just about reproduction; it is a critical biomarker for overall physical, mental, and immune health. Challenging the myth that sexual decline is an inevitable part of aging, Dr. Killen provides actionable advice on lifestyle choices, supplements, and the importance of open dialogue to help listeners reclaim their health span.References:Dr. Amy Killen on InstagramDr. Amy Killen on LinkedIn

In this episode of Up One, hosts Sawyer Stone and Dr. Bill Andrews pull back the curtain on the world of scientific publishing and health claims. Dr. Andrews explains that a standard meta-analysis is insufficient because the peer-reviewed literature is riddled with flawed or even fabricated data, often fueled by the pressure to "publish or perish" or by commercial bias. He defines critical meta-analysis (CMA) as the essential skill needed to determine a study's true credibility by examining experimental design, statistical integrity, and the common sense of its conclusions. Listeners will learn how easy it is to mistake correlation for causation and why a single "Betty White test" is often more trustworthy for assessing age reversal than quantitative biomarkers alone.References:Dr. Bill's talk in TokyoCoconut Oil and Alzheimer'sDr. Bill Andrews (he/him) is a molecular biologist and a pioneer in aging research, best known for discovering the human telomerase gene while at Geron Corporation. Now the CEO of Sierra Sciences, he is dedicated to finding therapies that activate telomerase to extend human lifespan. A passionate ultramarathoner, Dr. Andrews combines science and endurance in his mission to slow aging at the cellular level.Sawyer Stone (they/she) is the Director of Administrative Services at Touchstone Essentials, a wellness company rooted in clean, plant-based supplements. With a sharp eye for strategy and a deep commitment to operational excellence, Sawyer helps keep the company moving smoothly behind the scenes. Off the clock, Sawyer is a dedicated soccer player and is passionate about building community on and off the field.

In this episode of Up One, hosts Dr. Bill Andrews and Sawyer Stone cut through the noise to discuss what really impacts your heart's health. Dr. Andrews, with over 40 years of experience in cardiovascular research, tackles common myths about fats, detoxes, and exercise. He reveals surprising facts about the benefits of specific antioxidants and the hidden dangers of certain oils, based on his critical meta-analysis of peer-reviewed studies. Learn about the crucial role of inflammation, the impact of genetics, and the lifestyle habits you can adopt to keep your heart healthy and strong.References:Beat the Heart Attack Gene, by Bradley Bale M.D., Amy Doneen ARNP, Lisa Collier Cool Larry King https://www.amazon.com/Beat-Heart-Attack-Gene-Revolutionary/dp/1681620227The Kaufmann Protocol: https://kaufmannprotocol.com/Dr. Caldwell Esselstyn: https://www.dresselstyn.com/site/RAADFest: https://www.raadfest.com/?utm_source=google&utm_medium=cpc&utm_campaign=22278711824&utm_content=178335283151&utm_term=&gad_source=1&gad_campaignid=22278711824&gbraid=0AAAAADfIoUGbI2eg281nVYJAp1cCGIXqk&gclid=Cj0KCQjww4TGBhCKARIsAFLXndR9ORfxpC-S7K-lDnq3z6lIcDRuU-LaNOH1E0kpo2NFPgQESKbownQaAuqYEALw_wcBDr. Bill Andrews (he/him) is a molecular biologist and a pioneer in aging research, best known for discovering the human telomerase gene while at Geron Corporation. Now the CEO of Sierra Sciences, he is dedicated to finding therapies that activate telomerase to extend human lifespan. A passionate ultramarathoner, Dr. Andrews combines science and endurance in his mission to slow aging at the cellular level.Sawyer Stone (they/she) is the Director of Administrative Services at Touchstone Essentials, a wellness company rooted in clean, plant-based supplements. With a sharp eye for strategy and a deep commitment to operational excellence, Sawyer helps keep the company moving smoothly behind the scenes. Off the clock, Sawyer is a dedicated soccer player and is passionate about building community on and off the field

Many of us think blood sugar is only a concern for diabetics, but as Dr. Bill Andrews explains, glucose regulation plays a pivotal role in everyone's overall health. In this episode of Up One, Dr. Bill and co-host Sawyer Stone dive deep into the science of blood glucose, exploring how everything from the foods we eat to our daily habits can impact energy, cognitive function, and even the aging process. We'll debunk common myths, discover surprising facts about sugar substitutes, and learn practical strategies for managing your glucose levels to boost your longevity and disease prevention.Dr. Bill Andrews (he/him) is a molecular biologist and a pioneer in aging research, best known for discovering the human telomerase gene while at Geron Corporation. Now the CEO of Sierra Sciences, he is dedicated to finding therapies that activate telomerase to extend human lifespan. A passionate ultramarathoner, Dr. Andrews combines science and endurance in his mission to slow aging at the cellular level.Sawyer Stone (they/she) is the Director of Administrative Services at Touchstone Essentials, a wellness company rooted in clean, plant-based supplements. With a sharp eye for strategy and a deep commitment to operational excellence, Sawyer helps keep the company moving smoothly behind the scenes. Off the clock, Sawyer is a dedicated soccer player and is passionate about building community on and off the field.

What if aging isn’t just inevitable, but a solvable biological puzzle? In this inaugural episode of Up One, hosts Sawyer Stone and Dr. Bill Andrews take a deep dive into the science of aging—from the cellular wear and tear that kicks off the process to the role of telomeres, telomerase, and lifestyle choices in determining how long (and how well) we live.Dr. Bill breaks down the hard science behind why we age, challenges common misconceptions about anti-aging supplements and therapies, and reveals which interventions, like reducing inflammation and consistent, low-stress exercise, are actually worth your time. They also dig into controversial topics like senolytics, gene therapy, and whether humans could (or should) evolve beyond aging.If you're curious about whether we can extend healthspan, reverse cellular aging, or even outsmart our own biology, this episode separates science from hype with a critical meta-analysis of the latest research.Tune in to find out:Why telomeres are the “ride tickets” of cellular lifeThe evolutionary reason we age—and why that might be changingHow inflammation, lifestyle, and genetics shape your biological clockWhat’s legit (and what’s not) in the booming anti-aging industryWhy Dr. Bill says the key to longevity might be… keeping exercise funReferences:Inflammation Nation by Floyd ChiltonHealthy Heart, Healthy Brain by Bradley Bale, MD and Amy Doneen, DNP with Lisa Collier CoolPrevent and Reverse Heart Disease: The Revolutionary, Scientifically Proven, Nutrition-Based Cure by Dr. Caldwell EsselstynThe Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer by Dr. Elizabeth Blackburn and Dr. Elissa EpelDr. Bill Andrews (he/him) is a molecular biologist and a pioneer in aging research, best known for discovering the human telomerase gene while at Geron Corporation. Now the CEO of Sierra Sciences, he is dedicated to finding therapies that activate telomerase to extend human lifespan. A passionate ultramarathoner, Dr. Andrews combines science and endurance in his mission to slow aging at the cellular level.Sawyer Stone (they/she) is the Director of Administrative Services at Touchstone Essentials, a wellness company rooted in clean, plant-based supplements. With a sharp eye for strategy and a deep commitment to operational excellence, Sawyer helps keep the company moving smoothly behind the scenes. Off the clock, Sawyer is a dedicated soccer player and is passionate about building community on and off the field.