Immune

Tulika Singh joins Immune at AAI2026 to talk about the international partnerships that advance research on immunity to emerging flaviviruses and her research on the impact of prior Zika virus infection on susceptibility to Dengue virus disease. Host: Cindy Leifer Guest: Tulika Singh Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Harris Research Lab 2025 STAT Wunderkind award to Dr. Singh Neutralization of Zika with IgM developed in pregnancy (Cell, 2022) Infection history shapes Dengue response (Nat Comm, 2024) Longitudinal profiling of antibodies following Dengue infection (Nat Comm, 2026) Exposure to Zika and risk for Dengue (Sci Transl Med, 2024) AAI Public Policy Fellows Program Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Immune tackles papers on the breadth of human B cell responses following mRNA vaccination and on the role of mitochondria and reactive oxygen species in plasma B cell maintenance. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server mRNA flu vaccine expands B cell breadth (Nat Immunol, 2026) Mitochondrial ROS and plasma cells (Nat Commun, 2026) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Adam Waickman discusses the unusual reason he got into studying immunology just in humans, his important studies on Dengue virus vaccine antibodies, and the problematic phenomenon of antibody dependent enhancement. Host: Cindy Leifer Guest: Adam Waickman Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Waickman Lab Website Dengue virus human infection model (Sci Trans Med, 2022) mRNA vectored antibody against Dengue (Antiviral Res, 2025) B cell receptor enhancement of Dengue (PLoS Path, 2024) Dengue infection macrophage transcriptional profiles (J Virol, 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Stacy Horner discusses her work on innate detection of viruses, viral countermeasures, and the role of m(6)A RNA modifications in regulating antiviral immunity. Host: Cindy Leifer Guest: Stacy Horner Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Hepatitis virus proteases block host response (J Virol, 2012) Host RNA binds to MAVS (Science, 2024) m6A modifications modify innate response to viruses (Cell Chem Biol, 2024) UFMylation coordinates MAVS assembly for antiviral responses (bioRxiv, 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Kathryn Knoop and Marion Brunck join the Immune team to talk about their research and their podcast "Mucosal Immunology". Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Guests: Kathryn Knoop and Marion Brunck Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Knoop: Oral tolerance in early life review Knoop: Gamma delta T cells in neonatal sepsis Knoop: EGF and IgA in breastmilk Brunck: FcGR's in PMNS Brunck: CRISPR KO to study FcGR's in human PMN Brunck: Leukocytes in breastmilk review Mucosal Immunology podcast Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Immune discusses a snippet on how EBV infection alters the immunopeptidome and promotes multiple sclerosis, and a paper on head and neck cancers harboring bacteria that create an immunosuppressive environment and promote immunotherapy resistance. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server EBV, Golli-MBP presentation and multiple sclerosis (Cell, 2026) Intratumoral bacteria promote resistance to cancer immunotherapy (Nat Cancer, 2026) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Martha Alexander-Miller discusses why newborn and infant immune responses to vaccines are generally less effective and how we can make vaccines safer and more effective. Host: Cindy Leifer Guest: Martha Alexander-Miller Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Flu HA nanoparticle vaccine (Nat Comm, 2025) Sex-dependent adjuvant activity in newborns (Vaccines, 2024) Flu vaccine with R848 adjuvant (Vaccines, 2023) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Matters Microbial #130: The Holobiont — Animals, Microbes, and Ecology May 19, 2026 Today Dr. Kevin Kohl, Associate Professor of Biological Sciences at the University of Pittsburgh, joins the #QualityQuorum to discuss how he and his colleagues study the interplay between animals, their resident gut microbes, and the overarching concept of the holobiont. Host: Mark O. Martin Guest: Kevin Kohl Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode The One Health Microbiome Center at Pennsylvania State University. A very fine essay on the holobiont concept for non-microbiologists. A general introductory overview of the holobiont concept. The holobiont concept and the coral symbiosis. A partial history of the development of the holobiont concept. Dr. Casadevall suggests that context and thus outcomes describes the term "pathogen," and a similar analysis applies to the holobiont. A very short description of the holobiont concept. Another overview of the holobiont concept in general, coauthored by Dr. Kohl. Some basic rules for thinking about the holobiont concept. A video introduction to the holobiont concept, by Dr. Seth Bordenstein. I highly recommend this essay by the science writer Carl Zimmer, "The Human Lake," to think of the connections between lake ecology and microbial interactions with humans. Another wonderful article recommended by Dr. Kohl, by Dr. Margaret McFall-Ngai and coauthors, detailing the impact microbes have on animals over evolution and development. The wood rat – creosote – microbiome connection to the holobiont concept, discussed on this podcast (coauthored by Dr. Kohl). The fascinating work by Dr. Kohl and colleagues showing the relationship between tadpole development and pond microbes discussed in this podcast. A must read article by Dr. Kohl and colleagues, "Through the microbial looking glass: our shifting understanding of the holobiont and microbes as mediators of organismal biology," illustrates the development and influence of the holobiont concept. Dr. Richard Prum's book, "Performance All the Way Down," was discussed during this podcast. There is also a video where Dr. Prum discusses the ideas in this book, describing gene regulation as a performance. Dr. Kohl's faculty website. Dr. Kohl's (very interesting) research website. Intro music is by Reber Clark Send your questions and comments to [email protected]

Luke O'Neill recounts his role in discovering key components of the TLR signaling pathway, explains how pursuing unexpected research questions keeps him motivated, and reflects on his experiences as an entrepreneur founding biotech companies. Host: Cindy Leifer Guest: Luke O'Neill Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server O'Neill lab Identification of MAL in the TLR signaling pathway (Nature, 2001) GDF 15, immunometabolism and anti-inflammatories (An Rev Pharmacol Tox, 2026) Itaconate and regulation of inflammation (Nat Metab, 2024) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

The Immune team talks all about cytokines, from what they are to immunotherapies against them to treat diseases. Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Non-specific virus neutralization by IgM and complement (mBio 2026) Natural antibodies against viruses (Virology blog, 2009) Biologics against inflammatory cytokines (Int J Cell Bio, 2016) Biologics against allergic cytokines (JACI, 2022) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

The Immune team discusses a paper describing the negative effects of old B cells on T cells and longevity and a snippet on an interesting vaccine approach to promote competition between gut commensals. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Vaccine enhanced competition of gut bacteria (Science 2025) B cells drive immunosenescence and aging (Sci Immunol 2026) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Gabrielle Rizzuto from Memorial Sloan Kettering Cancer Center discusses her work on the curious immunology of pregnancy and how a woman tolerates a genetically different baby but quickly rejects a mismatched organ donation. Host: Cindy Leifer Guest: Gabrielle Rizzuto Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Rizzuto lab at MSKCC Tolerance at the fetal-maternal interface (Nature, 2022) The paradox of fetal-maternal tolerance (J Exp Med, 2022) Spatially resolved timeline of fetal-maternal interface (Nature, 2023) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Anna Beaudin from University of Utah talks about the key thread of her career, development, and how that influences her research on the events happening during critical prenatal windows shapes everything from the developing immune system to hearing loss. Host: Cindy Leifer Guest: Anna Beaudin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Beaudin lab at University of Utah PhD work on metabolism and development Postdoc work on hematopoietic stem cells Maternal inflammation and hematopoietic stem cell development Prenatal inflammation effect on postnatal immunity Early life inflammation and hearing loss Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.