JAMA Clinical Reviews

Heart transplant for patients with advanced heart failure can lead to improved survival and quality of life. Author JoAnne Lindenfeld, MD, of Vanderbilt University joins JAMA Associate Editor David Simel, MD, MHS, to discuss indications, transplant evaluation, management after transplant, long-term complications, and survival. Related Content: Heart Transplant for Advanced Heart Failure

Respiratory virus vaccine effectiveness and safety for influenza, RSV, and COVID-19 are reviewed, including new evidence, risks, and recommendations. JAMA Deputy Editor Preeti Malani, MD, MSJ, speaks with Rochelle Walensky, MD, MPH, professor of medicine at Harvard Medical School and former CDC Director, about vaccine data, public trust, and the 2026 respiratory virus season. Related Content: Respiratory Season Virus Vaccines RSV Immunization Effectiveness and Safety for the 2026-2027 Respiratory Season Influenza Vaccine Effectiveness and Safety for the 2026-2027 Respiratory Season COVID-19 Vaccine Effectiveness and Safety for the 2026-2027 Respiratory Season

Idiopathic normal pressure hydrocephalus (iNPH) affects approximately 1% to 4% of adults aged 65 years and older and is associated with gait impairment, cognitive decline, and urinary dysfunction. Author Mark G. Luciano, MD, PhD, from Johns Hopkins University, discusses this and more with JAMA Deputy Editor Kristin Walter, MD, MS. Related Content: Idiopathic Normal Pressure Hydrocephalus

Patient portal messaging continues to expand across health systems, and it has become an increasingly important method for patient-clinician communication. Authors Michal Mankowski, PhD, assistant professor, and Jane Long, MD, research resident, both from the Department of Surgery at NYU, discuss their new research letter with JAMA Deputy Editor Joseph Ross, MD, MHS. Related Content: Trends in Patient Portal Messages, Office Visits, and Telephone Encounters National Trends in Patient Messaging—The Growing Electronic Inbox

Cyanotic congenital heart diseases occur in approximately 0.2% of live births in the US, but survival to adulthood is common with current surgical interventions. JAMA Associate Editor David Simel, MD, MHS, speaks with author Michael Landzberg, MD, who coauthored a recent review in JAMA on this topic. Related Content: Survivors of Cyanotic Congenital Heart Disease

Cesarean delivery on maternal request requires individualized counseling. Reduced risks of pelvic floor disorders should be weighed against surgical risks and future risks including abnormal placentation. Author Marianna Alperin, MD, MS, from UC San Diego School of Medicine, discusses this and more with JAMA Deputy Editor Linda Brubaker, MD. Related Content: Cesarean Delivery on Maternal Request Cesarean Delivery—Reply Cesarean Delivery

Amyotrophic lateral sclerosis (ALS), which affects about 25 000 individuals in the US, causes progressive weakness but has varied presentations. Several FDA-approved medications are now available for ALS. Author John Ravits, MD, of UC San Diego School of Medicine joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss current evidence regarding diagnosis and treatment of ALS. Related Content: Amyotrophic Lateral Sclerosis Pridopidine in Amyotrophic Lateral Sclerosis What Is Amyotrophic Lateral Sclerosis? CNM-Au8 in Amyotrophic Lateral Sclerosis Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis Traumatic Brain Injury and Risk of Amyotrophic Lateral Sclerosis

Heart failure (HF) affects more than 64 million individuals worldwide, and 20% to 30% of patients with HF and systolic dysfunction have cardiac dyssynchrony due to conduction system disease. JAMA Review author Mihail Chelu, MD, PhD, of Baylor College of Medicine discusses cardiac resynchronization therapy with JAMA Associate Editor David Simel, MD, MHS. Related Content: Cardiac Resynchronization Therapy Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure