The Empowering Neurologist Podcast

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).3x4 Genetics - https://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.====What if the future of medicine isn't a smarter doctor, but a thinking partner that can hold your entire biology in mind at once? In this episode, Dr. Don Brown joins me to make the case that AI in medicine isn't a replacement for the clinician. It's an ally capable of seeing patterns no human brain could hold together on its own.Dr. Don Brown is a physician, computer scientist, and serial entrepreneur whose last software company sold for $1.4 billion in 2016. He returned to graduate school in his mid-50s to study biotechnology at Johns Hopkins, founded Lifeomic in 2017, and now leads Bioscope, a platform that uses AI to integrate a patient's entire biological picture into one dynamic view of health.We dig into why fragmented medicine fails at prevention, how Bioscope ingests the whole genome, microbiome, epigenome, and medical records into a single synoptic view, the real case where AI flagged arsenic toxicity in a patient misdiagnosed with restless leg syndrome, and what it looks like when AI personas begin guiding patients through their own protocols in real time.00:00 - Introduction 00:53 - A New Way to Think About Brain Health: Brain Defenders 03:18 - Welcoming Dr. Don Brown 06:46 - From Physics to MD to Software Entrepreneur 09:01 - Back to Grad School at Johns Hopkins 10:35 - The Lifeomic Years: Cancer Care in the Cloud 12:34 - The Spark Behind Bioscope 15:27 - Building the Ultra-Secure Health Data Repository 16:26 - 40 Hz Light Therapy and Cognitive Decline 18:26 - The Epigenome: Why Your Genes Aren't Your Destiny 19:32 - Decoding the Microbiome and Mitochondrial Genetics 22:25 - What AI Actually Does With Your Health Data 23:39 - The Synoptic View: Borrowing From Aviation26:36 - The 15 Dimensions of Health 29:23 - Why the Patient History Still Matters 30:23 - Inside the Bioscope Interface 31:38 - A Real Case: AI Catches Arsenic Toxicity 33:13 - Personalized Brain Health: 3X4 Genetics 35:10 - The Driverless Car Moment for Medicine 37:07 - Marketing to Concierge Physicians 40:33 - How Patient Data Gets Into the System 42:30 - Image Analysis and Specialized AI Partners 45:33 - The Biggest Misconception Patients Have About AI 47:14 - Meet Lumina: The Physician's AI Persona 48:00 - Cairo and the Future of AI Health Coaching 50:13 - Different AI Personas for Patients and Physicians 51:39 - Why Concierge Doctors Are Mobbing the Booth 55:00 - Closing Thoughts ___________________________Instagram: / davidperlmutter Website: https://www.drperlmutter.com/Subscribe to our channel: / @davidperlmuttermd

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱In our modern world, we are surrounded by a staggering number of invisible threats. These chemicals and pollutants can silently undermine our immune systems, increase our risk for chronic illness, and sabotage our health at the cellular level. That’s why I’m especially excited to welcome Dr. Aly Cohen to this episode of The Empowering Neurologist. This conversation is not only eye-opening, it’s empowering and filled with practical, actionable steps that each of us can take starting today.In our conversation Dr. Cohen takes us through the science and the soul of her mission. We explore what inspired her to write Detoxify, a journey that began at the intersection of clinical frustration and personal awakening. Over the years, she began noticing that many of her patients with autoimmune diseases, chronic fatigue, hormonal imbalances, and neurological complaints shared a common thread: consistent exposure to environmental toxins. This wasn't just about vague “bad stuff.”Dr. Cohen has zeroed in on a specific category of chemicals she terms “Immune-disrupting chemicals (IDCs).” These are substances that directly interfere with the immune system's ability to regulate and repair.Dr. Cohen doesn’t stop at theory… she gets specific - with personal care products to avoid, water purification tips every household should know, and simple DIY recipes for safer cleaning and skincare. Her “Detoxify Food Pyramid” reimagines what a clean, immune-supportive diet looks like in a world of processed foods and contaminated agriculture.We also touch on how environmental toxins can act as potent triggers for autoimmune conditions like lupus and rheumatoid arthritis - diseases Dr. Cohen treats in her clinical practice almost every day. If you’re feeling overwhelmed by the sheer scale of modern toxicity, this episode offers a clear and hopeful path forward. Dr. Cohen emphasizes that detoxifying your life doesn’t mean doing everything at once. It’s about starting small. Things like switching to a glass water bottle, choosing fragrance-free detergents, and reading ingredient labels can lead to profound health benefits.====TIMESTAMPS00:00 Introduction02:15 Welcoming Dr. Amy Cohen & Her Inspiration for Her Book05:45 Water & How Contamination Dysregulates Our Immune System10:44 Recommendations for Filtration and Purification13:13 Quality of Bottled Water Is Sub Par & Likely Tap Water18:03 Endocrine Disrupting Chemical Contaminants Found In Our Water21:47 Sparking Change with The Four A's: Assess, Avoid Or Swap, Add, Allow27:39 How Did These Chemicals Enter Our Food & Water Supply?34:10 How Do Genetics Determine Your Ability To Detoxify?37:50 Air Quality, Pollution, and The Impact On Our Bodies43:49 Navigating How To Improve The Air You Breath47:41 Detoxifying The Body From Air Pollution51:18 Hidden Threats In Your Personal Care Products & How To Avoid Them1:04:19 Conclusion====Dr. Aly Cohen is a board-certified physician practicing in rheumatology and integrative medicine, as well as an environmental health expert in Princeton, New Jersey. Her new book, DETOXIFY: The Everyday Toxins Harming Your Immune System and How to Defend Against Them, available now for preorder, connects the dots between everyday chemicals and the epidemic rise in immune disorders and autoimmune disease...and what we CAN all do about it! You can follow her health and wellness tips and recommendations on Facebook at The Smart Human, Twitter, and Instagram: @thesmarthuman, and TikTok. ___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Cancer remains a formidable global challenge, with nearly one in six deaths worldwide attributed to the disease. Over 60% of patients undergoing conventional treatments experience severe side effects, highlighting the need for complementary therapies that enhance efficacy and reduce harm.Dr. Valter Longo, a leading figure in aging and nutritional science, has introduced a groundbreaking approach known as the fasting mimicking diet (FMD). Through years of research, Dr. Longo has shown that cycles of controlled fasting can trigger cellular regeneration, reduce inflammation, and improve metabolic health.His work has reshaped our understanding of nutrition’s role in health and disease, providing a scientific basis for fasting as a tool to support standard cancer therapies. The fasting mimicking diet offers a promising adjunct to traditional treatments. By strategically reducing calorie intake, FMD protects healthy cells and makes cancer cells more vulnerable to chemotherapy and radiation.This dual effect boosts the effectiveness of treatment while mitigating debilitating side effects. Dr. Longo’s new book, Fasting Cancer, the subject of our podcast, explores the science behind fasting and its potential to transform cancer care. He shares practical guidelines, compelling case studies, and robust research that illustrate how FMD can be integrated with standard therapies for better outcomes.Listeners of The Empowering Neurologist were captivated by Dr. Longo’s ability to translate complex science into actionable advice in his previous appearance, and this episode is no exception. His work continues to inspire both patients and healthcare professionals to explore innovative, science-driven approaches in the fight against cancer.As research unfolds, the fasting mimicking diet stands as a testament to the power of nutritional science in modern medicine. Embracing this strategy, patients and clinicians alike are witnessing a promising future in cancer care.====00:00 Introduction02:10 The Cancer Nutrition Scientist Changing Everything04:36 How Cancer Cells Hack Aging And Stay Immortal06:00 The Hidden Danger Of Cancer Cell Survival After Chemo07:30 Why Young People Are Getting More Cancer Than Ever10:48 Are We Eating Too Much Protein For Longevity13:22 A Diet That Weakens Cancer But Shields Healthy Cells17:55 What Is The Fasting Mimicking Diet And Why It Works21:40 The Critical Timing That Makes Chemo More Effective23:00 How Starving Cancer Creates A Predictable Weak Spot27:30 The Multi-Angle Attack That Slows Glioblastoma29:15 Could This Diet Delay Or Reverse Alzheimer’s32:50 Clinical Trials Show This Diet Reverses Diabetes36:30 How Fasting Triggers Organ Regeneration In Humans41:05 The Shocking Risks Behind Popular Weight Loss Drugs57:14 Conclusion====Valter Longo is the director of the Longevity Institute at the University of Southern California in Los Angeles. He studies basic and clinical research on nutrition, aging, and disease, with a focus on cancer, autoimmunity, Alzheimer’s, and cardiometabolic illness. Dr. Longo has received multiple awards including the 2010 Nathan Shock Lecture Award from the National Institute on Aging, the 2013 Vincent Cristofalo Rising Star Award, and the 2016 Glenn Award for Research in the Biological Mechanisms of Aging. In 2018, Time named him one of the 50 most influential people in health care, and in 2021 Science magazine called him a pioneer in nutrition and cancer. He is the author of Fasting Cancer and The Longevity Diet.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱We hear so much these days about various “biohacking” techniques that are purported to be helpful for us in terms of improving our health and even extending our lifespan. But I think it's really important that we unpack some of these ideas and get a good understanding as to what they involve and what we can expect if we were to engage them. We're going to explore a variety of hot topics like exosome therapy, peptide therapy, cryotherapy hyperbaric oxygen therapy, and other innovative techniques. But most importantly we will explore how our simple, day-to-day lifestyle choices impact our health in terms of preserving our resistance to disease, and possibly even extending our lives.Our guest is Dr. Darshan Shah, a powerful influencer in the area of health-span improvement. Let me tell you a little bit more about Dr. Shah.Darshan Shah, MD, is a health and wellness specialist, board-certified surgeon, published author, entrepreneur, and founder of Next Health, the world's first and largest Health Optimization and Longevity clinic. As a Longevity Medicine specialist, he has advised thousands of patients on how to optimize their well-being and extend their healthspan and lifespan. Dr. Shah began his career at an accelerated MD program and earned his medical degree at the age of 21, becoming one of the youngest doctors in the United States. He continued his training at the Mayo Clinic, one of the most prestigious medical institutes in the country. Dr. Shah’s belief in continual education and self-improvement has earned him alumni status at Harvard Business School, Singularity University, and other prestigious institutions. His passion is speaking on the topics of longevity and health, having done over 100+ speaking engagements and appearances.0:00 Intro2:52 How Dr. Darshan Shah Began Studying Longevity9:14 The Next Health Clinic: Cutting-Edge Longevity Science12:11 The Biggest Health Mistake People Don't Realize14:47 Evaluating Biomarkers & Their Clinical Importance20:52 Key Biomarkers to Monitor Inflammation & Uric Acid23:43 Why Uric Acid Matters25:32 Clarifying the Confusion Surrounding Cholesterol29:20 Hormone Levels as a Key Marker of Health (TRT)35:22 Cutting Edge Science: Peptide Therapy 41:54 The Success of These Treatments43:05 Science of Exosome Therapy 44:55 NAD & Stimulating the Mitochondria46:41 Effectiveness of Cryotherapy48:19 How Mainstream Physicians View this Approach50:37 Cognitive Decline52:09 His #1 Health Practice for Longevity53:40 Conclusion====Dr. Darshan Shah is a health optimization expert, board-certified surgeon, and founder of Next Health, the world’s first Health Optimization and Longevity clinic. A graduate of an accelerated MD program, he earned his medical degree at 21 and trained at the Mayo Clinic. With over 20,000 surgeries performed and multiple ventures in the wellness space, Dr. Shah now focuses on helping people extend their healthspan through cutting-edge science and personalized care. He’s also a sought-after speaker and lifelong learner with credentials from Harvard Business School and Singularity University.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Yes, we need stress in our lives! Staying in our comfort zone may be doing us more harm than good. That’s probably surprising to hear from me having spoken about the importance of reducing stress over the years. But, nonetheless, a level of stress that is not overly damaging, and that may actually have positive benefits. Today we are going to learn much more about that will be looking at the book, The Stress Paradox with Dr. Sharon Horesh Bergquist. We're going to learn about the"Stress dilemma" that we face, how stress enhances, cellular resilience, how our life compares to the lives of our ancestors in terms of the physical stresses that we endure. We will explore how stressing ourselves in relation to the times that we eat, our physical exercise, and even explore how sleep or lack of sleep, may affect us in negative and even perhaps positive ways. All in all, we"re learning these days how we want to do our best to leverage the value of being out of our comfort zone but also recognizing ourboundaries. 00:00 Introduction02:00 Welcoming Sharon and Introducing The Stress Paradox06:33 Sleep is Critical07:12 Good Stress (HIIT) vs. Bad Stress (Financial Hardship)09:50 Hormetic Stress? Current Environment vs. Ancestors' Stress Levels13:20 Stress Responses Stored in Phytochemicals and our Evolutionary Relationship with Plants19:01 10,000 DNA Injuries Any Given Day, 7 Per Minute22:03 The Biggest Factor Related to Longevity26:01 Relationship with Decreased Risk of Alzheimer’s & The Role of Myokines30:17 Microglia Cells Can Share Mitochondria (Before & After)35:13 Heat Exposure Mimics the Benefits of Exercise38:01 Key Strategies for Longevity and Vitality45:32 Personalized Health Strategies for Optimal Performance50:25: The Cortisol Spike and Why It is Necessary 58:20 Why You Need Non-negotiables In Your Physiology50:20 Conclusion====Sharon Horesh Bergquist, MD, is an award-winning physician, innovative healthcare leader, and visionary researcher renowned for spearheading a science-based approach to applying lifestyle as medicine. She has helped lead numerous clinical trials, including the Emory Healthy Aging Study and the NIH funded Emory Healthy Brain Study. Dr. Bergquist is widely published in peer-reviewed journals and has contributed to over 200 news___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱We all know that exercise is good for the body and specifically, very good for the brain. In fact, exercise is the most important inroad to better brain health, better brain function, protecting the brain against decline, and even with respect to mood issues like depression.But it's reasonable to ask how in fact does this work? How is it that exercising muscles does good things for the brain?On today's episode of the Empowering Neurologist we spent time with Dr. Austin Perlmutter. He takes us on a deep dive exploring the exact connection between muscle and its endocrine function in terms of creating various chemicals that are so helpful for better brain health. It's a great discussion that looks at things like how much exercise is appropriate, what type of exercise is best, how much protein we should be consuming, and what other supplements will augment the benefits of exercise in terms of better brain health. I think you will really enjoy this episode. I know I sure did, after all, getting to spend time with my son is always special!=====00:00:00 Introduction & Welcoming Dr. Austin00:01:56 The Relationship of Muscle Health, Mental Health, and Brain Health00:09:15 The Power of Exercise to Improve Cognition vs Pharmaceuticals & The Muscle as an Endocrine Organ00:16:36 The Molecules Produced by Muscles: Myokines 00:20:10 Myokines, Inflammation, and Metabolic Health 00:26:43 Sarcopenia and The Risk of Dementia00:31:50 Brain Derived Neurotropic Factor, Neuroplasticity & Weight Training 00:39:40 Animal versus Plant Protein to Build Healthy Muscle00:46:26 Cycling Anabolic and Catabolic States00:51:31 Why Women Are 2x More Likely to Develop Alzheimer's and What Supplementation Is Necessary to Compliment Building Muscle01:05:40 Conclusion and Wrap Up=====Dr. Austin Perlmutter is a board-certified internal medicine physician, New York Times bestselling author, researcher, educator, podcaster and entrepreneur. His mission is to help people get their brains unstuck for better mental and cognitive health. Dr. Perlmutter’s work on how environment and diet influences brain health has been featured on PBS, Rolling Stone, Newsweek, NPR, Fox, CBS and other top media outlets. He has co-produced and hosted some of the world’s largest online brain health events including Alzheimer’s, the Science of Prevention and the Better Brain Blueprint. He is the Managing Director of Big Bold Health, where he led a pioneering study exploring plant nutrient effects on human aging. He is the CEO of Lichen Air, which provides science-backed indoor air solutions for better brain health and longevity. He is also a research consultant to the Helfgott Research Institute, where he studies the epigenetic, metabolic, microbiome and immune effects of ayahuasca. Website: https://www.austinperlmutter.com/YouTube: https://www.youtube.com/@draustinperlmutterIG: https: https://www.instagram.com/draustinperlmutter/Lichen AIr: https://lichenair.com/Dr. Austin Perlmutter's Muscle-Brain eGuide: https://www.austinperlmutter.com/muscleguide___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1