The Latest GLP-1 Science on Muscle Loss, Fat Loss, and Weight Regain | Ep 461

About this episode

This episode discusses the effects of GLP-1 drugs on fat loss, muscle retention, and long-term safety based on recent trials.

What REALLY happens when you take a GLP-1 drug? Your fat loss, your muscle, your heart, your inflammation, what happens to your weight when you stop, and long-term safety. This episode covers body composition data from the 2026 semaglutide and tirzepatide trials, cardiovascular outcomes from SELECT and SURPASS-CVOT, inflammation findings beyond weight loss, weight regain patterns after stopping, and a 5-part framework to keep muscle on or off the drug after 40. Plus the 2026 safety upda...

People in this episode

Host: Philip Pape

Topics covered

• GLP-1 drugs
• muscle loss
• fat loss
• weight regain
• body composition
• cardiovascular outcomes
• long-term safety

Keywords

• GLP-1
• muscle loss
• fat loss
• weight regain
• semaglutide
• tirzepatide
• cardiovascular health
• inflammation
• body composition
• safety update

Mentioned in this episode

Organizations: SELECT, SURPASS-CVOT

Products: GLP-1 drug, semaglutide, tirzepatide

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