PETAL Consortium Survival Prognosticators and How Inflammation Impacts Hematopoiesis

About this episode

This episode features an interview discussing the prognostic significance of early relapse in T-cell lymphomas and the impact of inflammation on hematopoiesis.

In this week's episode, Blood associate editor Dr. Laura Michaelis interviews Drs. Mark Sorial and Emmanuelle Passegue on their articles published in volume 147 issue 7 of Blood . Dr. Sorial discusses " Early time to relapse as a survival prognosticator in nodal mature T-cell lymphomas: results from the PETAL consortium " where he and his team evaluated the prognostic significance of early relapse in a large retrospective cohort. They report a time to relapse of <12 months as a strong predictive factor independent of the prognostic index for T-cell lymphoma and histology, with results validated in 2 independent cohorts. Dr. Emmanuelle Passegue discusses " Inflammation perturbs hematopoiesis by remodeling specific compartments of the bone marrow niche ". Using a combination of single-cell RNA sequencing profiling and flow cytometry, the team characterized the bone marrow niche compartments in mice subjected to inflammation. They show that inter-feron-mediated inflammation preferentially targets central marrow leptin receptor–expressing mesenchymal cells, triggering cytokine release that affects monocyte dynamics in the bone marrow microenvironment.

People in this episode

Host: Dr. Laura Michaelis

Guests: Dr. Mark Sorial, Dr. Emmanuelle Passegue

Topics covered

• prognostic significance
• inflammation
• hematopoiesis
• T-cell lymphomas
• bone marrow niche
• single-cell RNA sequencing

Keywords

• T-cell lymphomas
• early relapse
• inflammation
• hematopoiesis
• bone marrow
• cytokine release
• single-cell RNA sequencing

Mentioned in this episode

Organizations: PETAL consortium

Books & works: Early time to relapse as a survival prognosticator in nodal mature T-cell lymphomas: results from the PETAL consortium, Blood

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