Into the Impossible With Brian Keating

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥 Michael Wong recently discussed theory of evolution on TED: https://www.youtube.com/watch?v=DSrf7ErdHWA — in this conversation, we go deeper on the law of increasing functional information and what it means for life, complexity, and the future of science. 🔔 Subscribe for new episodes each week 🎧 Ad-free episodes on Patreon: patreon.com/drbriankeating INTO THE IMPOSSIBLE — where Nobel Prize winners, physicists, and bold thinkers explore the biggest questions in science. Is there a second arrow of time? Astrobiologist and planetary scientist Dr. Michael Wong joins Brian Keating to explore the law of increasing functional information — a proposed new law of nature that may explain how complexity evolves across minerals, biology, AI, and the cosmos. Dr. Michael Wong of the Carnegie Institution for Science has been working with a cross-disciplinary group of scientists — the "Missing Law Group" — to propose something bold: a new law of nature. Their law of increasing functional information argues that evolving systems, whether biological or not, tend toward greater complexity and function over time. In this conversation, Brian and Michael unpack what functional information actually means, how it differs from Shannon entropy, and why it may describe something fundamental about the universe we live in. From the formation of minerals in stellar atmospheres to the evolution of life on Earth, Michael walks through how this framework applies across planetary science, astrobiology, and even cancer research. Brian pushes on the hard questions — the Fermi paradox, the boundary conditions of the law, its relationship to the second law of thermodynamics, and whether it truly qualifies as a "law" at all. Sean Carroll blurbed the book and later called it out on his podcast — Brian asks Michael about that tension directly. They also get into panspermia, the contingent role of cosmic collisions in shaping Earth's evolutionary history, the search for biosignatures on Mars and beyond, and what the rise of generative AI looks like through the lens of selection for function. This is a wide-ranging, technically honest conversation about one of the most ambitious proposals in contemporary science. Key Takeaways: 00:00:35 There May Be a Second Arrow of Time — and It Points Toward Complexity 00:01:35 The Law of Increasing Functional Information Explains How the Universe Evolves 00:07:15 Functional Information Measures How Well a System Performs a Specific Function 00:11:30 Three Universal Selection Pressures Drive All Evolving Systems 00:18:00 Mineral Evolution on Earth Is a Measurable Proof of the Law in Action 00:22:00 The Law Is a Tendency, Not a Guarantee — It Doesn't Resolve the Fermi Paradox 00:27:00 Life and Non-Life Contain the Same Building Blocks — the Difference Is in the Distributions 00:32:15 Cosmic Collisions Didn't Derail Evolution — They Opened New Possibility Spaces 00:50:00 Cancer Behaves Like an Evolving System — and That Could Change How We Treat It 01:05:15 AI Is a New Form of Evolving Life — and Without Stronger Selection Pressure, It's DangerousFeatured Guest ➡️ Follow Michael Wong 🌐 Website: https://miquai.myportfolio.com/ 📚 The book: Time’s Second Arrow (co-authored with Robert Hazen) : https://www.amazon.com/Times-Second-Arrow-Evolution-Nature-ebook/dp/B0FJ2ZJL53 🏄‍♂️ Twitter: https://x.com/miquai — Brian's Links Join this channel to get access to perks like monthly Office Hours: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join 📚 Get my books: Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U Losing the Nobel Prize: http://amzn.to/2sa5UpA Dialogue Concerning the Two Chief World Systems (audiobook): https://a.co/d/iZPi9Un Follow me to ask questions of my guests: 🏄‍♂️ Twitter: https://twitter.com/DrBrianKeating 🔔 Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1 📝 Mailing list: http://briankeating.com/list ✍️ Blog: https://briankeating.com/blog 🎙️ Audio-only: https://briankeating.com/podcast — #physics #astrobiology #complexity #evolutionoflife #briankeating #intotheimpossible Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/yt to win a meteorite 💥 In this episode of The INTO THE IMPOSSIBLE Podcast, Brian Keating sits down with Andy Weir, the bestselling author of The Martian and Project Hail Mary, to explore the real science behind one of the most ambitious science fiction stories ever written. With the upcoming film adaptation of Project Hail Mary generating excitement among fans, we dig into the physics, astrophysics, and speculative biology that make the story so compelling. Could the mysterious energy source known as astrophage actually exist? What does real astrophysics say about interstellar travel, relativistic journeys, and humanity’s chances of reaching nearby star systems? Andy Weir explains how he builds scientifically grounded worlds while still telling gripping stories, and Brian breaks down which elements of the novel are plausible according to modern physics. The conversation also explores the process of writing hard science fiction, how scientific accuracy shapes storytelling, and why readers and scientists alike have embraced Project Hail Mary as one of the most scientifically informed sci-fi novels of the last decade. Along the way, Brian and Andy discuss the challenges of adapting such a technically rich story into a major Hollywood film and what audiences might expect when the movie arrives. If you enjoy deep conversations about physics, astronomy, science fiction, and the boundary between imagination and reality, this episode will give you a fascinating look at how real science inspires great storytelling. - Key Takeaways: 00:00 Andy Weir Discusses 'Project Hail Mary' 10:44 "Balancing Science and Creativity" 16:03 "Global Unity Against Common Threats" 18:56 Amateurs Driving Innovation 25:35 Fermi Paradox: Light Speed Limit 29:30 "Building a Shared Language" 35:32 "5,000 Words Weekly Writing System" 46:58 UCSD Physics Experience Reflection 51:23 "Colleges Should Be Trade Schools" 57:08 Billion-Year Human Legacy Capsule - Join this channel to get access to perks like monthly Office Hours: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join 📚 Get my books: Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un Follow me to ask questions of my guests: 🏄‍♂️ Twitter: https://twitter.com/DrBrianKeating 🔔 Subscribe https://www.youtube.com/DrBrianKeating?sub_confirmation=1 📝 Join my mailing list; just click here http://briankeating.com/list ✍️ Detailed Blog posts here: https://briankeating.com/blog 🎙️ Listen on audio-only platforms: https://briankeating.com/podcast #universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #andyweir #projecthailmary #themartian #sciencefiction #hardsciencefiction #scifibooks #spacescience Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥 Aswath Damodaran joins Brian Keating to argue that markets, universities, and financial models are all suffering the same disease — mistaking mechanical processes for genuine thinking — and explains why Nobel economists aren't billionaires, why academia is the most deserving target for disruption, and why every major asset class is now overpriced with nowhere left to hide. 00:00 Intro 00:01:37 Why Nobel Economists Aren't Billionaires 00:06:08 Universities Have Completely Lost the Plot 00:07:43 95% of Academic Research Is Worthless 00:13:05 The University Is a Sticky Business — But Cracks Are Forming 00:40:00 ChatGPT Already Does What Bankers Charge Millions For 00:46:43 The Most Dangerous Number in Finance 00:52:35 There Is No Safe Place Left to Put Your Money 00:55:48 When Every Asset Is Overpriced, Buy What You Love 01:00:22 We Are Losing Our Ability to Think 01:01:30 Markets Are Smarter Than Experts — Every Single Time ➡️ Follow Aswath Damodaran 🌐 Website: https://pages.stern.nyu.edu/~adamodar/ 📚 The Little Book of Valuation: https://pages.stern.nyu.edu/~adamodar/ 📝 Musings on Markets (Substack): https://aswathdamodaran.substack.com Join this channel to get access to perks like monthly Office Hours: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join 📚 Get my books: Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un Follow me to ask questions of my guests: 🏄‍♂️ Twitter: https://twitter.com/DrBrianKeating 🔔 Subscribe https://www.youtube.com/DrBrianKeating?sub_confirmation=1 📝 Join my mailing list; just click here http://briankeating.com/list ✍️ Detailed Blog posts here: https://briankeating.com/blog 🎙️ Listen on audio-only platforms: https://briankeating.com/podcast #universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #briankeating Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/yt to win a meteorite 💥 Nick Lane joins Brian Keating to argue that life is not information running on chemistry but energy in motion—showing how a single ancient metabolic “transformer” predates genes, powers mitochondria, shapes aging and cancer, constrains alien life, and reveals why today’s AI excitement echoes a solution biology discovered billions of years ago. 00:00 — Defining life vs. death; membrane potential as the boundary between living and dead 00:50 — The title “Transformer” and parallels between AI transformers and biochemical transformation 03:22 — Schrödinger’s What Is Life? and why defining life is intrinsically slippery 06:25 — Why the Krebs cycle sits at the center of metabolism 08:45 — The reverse Krebs cycle, CO₂ fixation, and links to cancer metabolism 11:35 — Mitochondrial membrane potential and the electrical field that powers life 15:00 — Reverse Krebs cycle vs. Calvin cycle and the evolution of carbon fixation 18:00 — Endosymbiosis: origin of mitochondria and chloroplasts 30:02 — Metabolism before genes; CO₂ + hydrogen and prebiotic chemistry 59:49 — Rapid-fire Q&A: RNA world critique and big open questions in origin-of-life research ------------------------------------------------------ ➡️ Follow Nick Lane 🌐 Website: https://www.nick-lane.net 📚 Transformer: The Deep Chemistry of Life and Death: https://nick-lane.net/books/transformer-the-deep-chemistry-of-life-and-death/ Join this channel to get access to perks like monthly Office Hours: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join 📚 Get my books: Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un Follow me to ask questions of my guests: 🏄‍♂️ Twitter: https://twitter.com/DrBrianKeating 🔔 Subscribe https://www.youtube.com/DrBrianKeating?sub_confirmation=1 📝 Join my mailing list; just click here http://briankeating.com/list ✍️ Detailed Blog posts here: https://briankeating.com/blog 🎙️ Listen on audio-only platforms: https://briankeating.com/podcast #universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #briankeating Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/yt to win a meteorite 💥 In this conversation, I break down a provocative idea: science doesn’t “prove” ultimate truths — it eliminates what’s false. And if that’s how physics works, then the search for God (or the disproof of God) has to play by the same rules: hypotheses, predictions, and falsifiability. ------------------------------------------------------ Join this channel to get access to perks like monthly Office Hours: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join 📚 Get my books: Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un Follow me to ask questions of my guests: 🏄‍♂️ Twitter: https://twitter.com/DrBrianKeating 🔔 Subscribe https://www.youtube.com/DrBrianKeating?sub_confirmation=1 📝 Join my mailing list; just click here http://briankeating.com/list ✍️ Detailed Blog posts here: https://briankeating.com/blog 🎙️ Listen on audio-only platforms: https://briankeating.com/podcast #universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #briankeating Learn more about your ad choices. Visit megaphone.fm/adchoices

Please join my mailing list here 👉 https://briankeating.com/yt to win a meteorite 💥 What can we truly learn about the brain from a kidney cell? And what do aliens and alien-like limbs have to teach us? And if language is our escape velocity moment, what does that mean for the future of AI? Nikolay Kukushkin is a scientist who believes that memory, intelligence, and even the roots of awareness may exist in places we never thought to look in. The timing of molecules in the learning of single cells, in the slow abstractions of evolution. He takes us through all of this in this wonderful new book, One Hand Clapping. Now let's go into the impossible. KEY TAKEAWAYS 00:00 "Sea Slugs and Abstract Thought" 09:55 "Cell Intelligence and Sound" 10:47 Cellular Intelligence and Memory 19:22 "One Hand Clapping: Zen Riddle" 23:18 "Evolution of Inner Worlds" 31:05 "Einstein, Thought Experiments, and LLMs" 32:50 "Can LLMs Achieve Life?" 38:01 Alien Encounters: Unlikely Similarity 45:39 Unanticipated Findings on Cellular Memory 53:33 "Interdisciplinary Creativity and Slow Multitasking" 55:58 Evolution of the Gut 01:04:57 "Interconnection and Existential Koan" 01:08:19 "Reconstructing Nature's Patterns" 01:13:55 "Evolution of Brain's Role" - Additional resources: Get My NEW Book: Focus Like a Nobel Prize Winner: https://www.amazon.com/dp/B0FN8DH6SX?ref_=pe_93986420_775043100 Join this channel to get access to perks like monthly Office Hours: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join 📚 Get a copy of my books: Think Like a Nobel Prize Winner, with life changing interviews with 9 Nobel Prizewinners: https://a.co/d/03ezQFu My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un 📺 Watch my most popular videos:📺 Neil Turok https://www.youtube.com/watch?v=Dt5cFLN65fI Frank Wilczek https://youtu.be/3z8RqKMQHe0?sub_confirmation=1 Eric Weinstein vs. Stephen Wolfram https://www.youtube.com/watch?v=OI0AZ4Y4Ip4?sub_confirmation=1 Sir Roger Penrose: https://youtu.be/AMuqyAvX7Wo Sabine Hossenfelder: https://youtu.be/g00ilS6tBvs Avi Loeb: https://youtu.be/N9lUceHsLRw Follow me to ask questions of my guests: 🏄‍♂️ Twitter: https://twitter.com/DrBrianKeating 🔔 Subscribe https://www.youtube.com/DrBrianKeating?sub_confirmation=1 📝 Join my mailing list; just click here http://briankeating.com/list ✍️ Detailed Blog posts here: https://briankeating.com/blog 🎙️ Listen on audio-only platforms: https://briankeating.com/podcast #universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #briankeating #NikolayKukushkin Learn more about your ad choices. Visit megaphone.fm/adchoices

WANTED: Developers and STEM experts! Get paid to create benchmarks and improve AI models. Sign up for Alignerr using our link: https://alignerr.com/?referral-source=briankeating One of the most powerful AI systems we’ve ever built is succeeding for reasons we still don’t understand. And worse, they may succeed for reasons that might lock us into the wrong future for humanity. Today’s guest is Anil Ananthaswamy, an award-winning science writer and one of the clearest thinkers on the mathematical foundations of machine learning. In this conversation, we’re not just talking about new demos, incremental improvements, or updates on new models being released. We’re asking even harder questions: Why does the mathematics of machine learning work at all? How do these models succeed when they suffer from problems like overparameterization and lack of training data? And are large language models revealing deep structure, or are they just producing very convincing illusions and causing us to face an increasingly AI-slop-driven future? KEY TAKEAWAYS 00:00 — Book explores why ML works through math 02:47 — Perceptron proof shows simple math guarantees learning 05:11 — Early AI failed due to single-layer limits 07:12 — Nonlinear limits caused the first AI winter 09:04 — Backpropagation revived neural networks 10:59 — GPUs + big data enabled deep learning 15:25 — AI success risks technological lock-in 17:30 — LLMs lack human-like learning and embodiment 22:57 — High-dimensional spaces power ML behavior 27:36 — Data saturation may slow future gains 31:11 — Continual learning is still missing in AI 33:46 — Neuromorphic chips promise energy efficiency 41:49 — Overparameterized models still generalize well 45:05 — SGD succeeds via randomness in complex landscapes 48:27 — Perceptrons remain the core of modern neural net - Additional resources: Anil's NEW Book "Why Machines Learn: The Elegant Math Behind Modern AI": https://www.amazon.com/Why-Machines-Learn-Elegant-Behind/dp/0593185749 Get My NEW Book: Focus Like a Nobel Prize Winner: https://www.amazon.com/dp/B0FN8DH6SX?ref_=pe_93986420_775043100 Please join my mailing list here 👉 https://briankeating.com/yt to win a meteorite 💥 - Join this channel to get access to perks like monthly Office Hours: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join 📚 Get a copy of my books: Think Like a Nobel Prize Winner, with life changing interviews with 9 Nobel Prizewinners: https://a.co/d/03ezQFu My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un 📺 Watch my most popular videos:📺 Neil Turok https://www.youtube.com/watch?v=Dt5cFLN65fI Frank Wilczek https://youtu.be/3z8RqKMQHe0?sub_confirmation=1 Eric Weinstein vs. Stephen Wolfram https://www.youtube.com/watch?v=OI0AZ4Y4Ip4?sub_confirmation=1 Sir Roger Penrose: https://youtu.be/AMuqyAvX7Wo Sabine Hossenfelder: https://youtu.be/g00ilS6tBvs Avi Loeb: https://youtu.be/N9lUceHsLRw Follow me to ask questions of my guests: 🏄‍♂️ Twitter: https://twitter.com/DrBrianKeating 🔔 Subscribe https://www.youtube.com/DrBrianKeating?sub_confirmation=1 📝 Join my mailing list; just click here http://briankeating.com/list ✍️ Detailed Blog posts here: https://briankeating.com/blog 🎙️ Listen on audio-only platforms: https://briankeating.com/podcast #universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #briankeating #AnilAnanthaswamy Learn more about your ad choices. Visit megaphone.fm/adchoices

Win a $100 Amazon Gift Card! Help me help you get great guests on the Into the Impossible podcast and spread the message throughout the universe. Fill out this listener survey: https://forms.gle/EUKzyE2ZqXDYJ2F47 Please join my mailing list here 👉 https://briankeating.com/yt to win a meteorite 💥 --- Enjoy this classic episode from the vault: Max Tegmark & Eric Weinstein, New Years Eve 2020! Brian Keating brings together two thought leaders at the edge of physics and philosophy: Max Tegmark, physicist, cosmologist, and pioneer at MIT, and Eric Weinstein, mathematician, economist, and creator of Geometric Unity. Timestamps: 00:00 "Ambitions in AI, Physics, News" 16:58 "Emergent Reality from Proto-Spacetime" 22:50 "Rethinking Unification in Physics" 36:09 "Value of Disagreeable Individualism" 45:32 "Optimism for Academia Careers" 01:04:08 "Dangers of Oversimplifying Physics" 01:07:34 "On Success, Science, and Wonder" 01:18:47 "Funding and Advancing Physics Research" 01:30:28 "Perspective on Science and Society" 01:43:13 "Three Types of Scientific Experiments" 01:52:05 "Collaboration and Discovery in Science" 02:02:20 "The Messiness of Scientific Truth" 02:13:08 "Simulation, AI, and Ethics" 02:20:55 "Limits of Technology in Cosmos" --- Join this channel to get access to perks like monthly Office Hours: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join 📚 Get my books: Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un Follow me to ask questions of my guests: 🏄‍♂️ Twitter: https://twitter.com/DrBrianKeating 🔔 Subscribe https://www.youtube.com/DrBrianKeating?sub_confirmation=1 📝 Join my mailing list; just click here http://briankeating.com/list ✍️ Detailed Blog posts here: https://briankeating.com/blog 🎙️ Listen on audio-only platforms: https://briankeating.com/podcast #universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #briankeating Learn more about your ad choices. Visit megaphone.fm/adchoices