Project 100

  All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. ****   Dr. Dani Antonellos is an osteopath with a doctorate in osteopathy, a personal trainer, and a former professional bikini bodybuilding competitor who recognised early in her career the dangerous disconnect between allied health practice and gym-based exercise. In this episode of Project 100, she and Mark Bouris work through the fundamentals of resistance training for longevity — covering exercise prescription, injury prevention, warmup protocols, progressive overload, and why movement, not rest, is almost always the right response to injury. The conversation is grounded in clinical experience and practical application, designed for anyone trying to make sense of the noise around strength training and long-term health.See omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** Lucas Aoun is a naturopath and men's health researcher with a Bachelor of Health Science whose work on natural testosterone optimisation gained the attention of Andrew Huberman. In this episode, he walks through the full hormone production pathway from the hypothalamus to the testes, explains which blood markers most GPs overlook, and outlines the lifestyle, nutrition, and supplementation strategies he has used to bring his own testosterone to near-1,000 nanograms per deciliter naturally. The conversation also covers structural causes of low testosterone, the role of HBOT and sleep in hormone health, and when TRT becomes the appropriate next step. Check out Lucas's stack here: https://www.inb4supps.com/products/peak-tSee omnystudio.com/listener for privacy information.

Most people taking supplements are wasting their money — not because supplements don't work, but because what they're swallowing never actually reaches the cells that need it. Bioavailability scientist George Kokkinis has spent 30 years at the intersection of chemistry, regulation, and human performance, and what he shares in this episode will change how you read every supplement label. From vitamin D3 and NMN to berberine, CoQ10, and omega-3s, we break down what's actually getting absorbed, what's heading straight to the toilet, and what to look for before you spend another dollar. This is the supplement conversation nobody in the industry wants you to have.See omnystudio.com/listener for privacy information.

Dr Stacy Sims is one of the world's leading exercise physiologists and nutrition scientists specialising in women's health, and she joins Project 100 to explain why the science women have been given is largely based on male data — and what that means for how women should actually train, eat, and protect their healthspan. From the cellular differences between the sexes, to perimenopause, creatine, protein timing, Alzheimer's risk, and why sleep beats everything else — this is a conversation every woman (and the people who love them) needs to hear.See omnystudio.com/listener for privacy information.

Tim Piatowski is one of Australia's leading researchers on peptides and enhancement drugs, running the world's first steroid-checking trial and service. In this conversation, we cover everything from what peptides actually are to the underground markets driving their use across Australia. Tim explains the science behind popular compounds like BPC-157 and GHK-Cu, the risks of unregulated products, and why Australia's regulatory approach is pushing people toward dangerous illicit markets. We also explore the potential for peptides in healthy ageing, injury recovery, and why our government's silence on this growing trend is creating more problems than solutions. We speak about: • What peptides are and how they work as signalling molecules • BPC-157 for tissue healing and inflammation reduction • GHK-Cu copper peptides for collagen synthesis and skin health • Growth hormone releasing peptides like CJC-1295 and tesamorelin • The contamination crisis in illicit enhancement drugs • Legal pathways vs underground markets in Australia • How peptides could transform healthy ageing and falls preventionSee omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. ****Professor Matthew Kiernan is CEO of Neura and one of the nation's leading neurologists tackling the growing dementia crisis. Kiernan explores why dementia is now Australia's number one cause of death, the modifiable risk factors that could prevent 45% of cases, and the groundbreaking monoclonal antibody treatments now available for Alzheimer's disease. Kiernan explains how the Western Pacific region carries 60% of the world's dementia burden and why researchers are racing to develop blood biomarkers that could detect brain diseases decades before symptoms appear. We also get into:• Why dementia has overtaken heart disease as Australia's leading killer • The role of vascular health in brain function and cognitive decline • Blood biomarkers coming within five years for early detection • Monoclonal antibody treatments for Alzheimer's now available in Australia • The connection between contact sports, head injuries and neurodegeneration • How GLP-1 medications are showing promise for brain health • Sleep's critical role in clearing toxic proteins from the brain Join my exclusive Mentored+ community: https://mentored.com.au/become-a-member/ Subscribe to the Mentored newsletter here: https://mentored.com.au/newsletterSee omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** Dr. Anastasia Hronis brings unique expertise to addiction psychology, exploring how modern technology is rewiring our brains for dependency. Her surname literally means "long years" — fitting for a conversation about optimising our relationship with dopamine-driven behaviours for longevity. We spoke about: • Understanding addiction versus obsession: the neurological differences • How dopamine pathways become primed for unhealthy patterns • Why poker machines and social media apps use identical addiction mechanics • The critical role of frustration tolerance in building resilience • Why today's youth face unprecedented challenges to mental wellbeing • Practical strategies for "prescribed boredom" and digital detox • The alarming parallels between gambling platforms and social media design This conversation reveals how our convenience-driven world undermines the very psychological resources we need for a fulfilling, long life. All content is for informational purposes only and is not medical advice. The all-new WHOOP is here — now 7% smaller with 14+ days of battery life. New features like Healthspan show how your daily habits are affecting your rate of aging — and now you can check your blood pressure straight from your wrist. If you’re serious about performance, longevity, and actual progress — this is it. Sign up for a one-month free trial at WHOOP.com — or visit join.whoop.com/mentored for one month off your annual membership fee.  Eight Sleep’s newest generation, Pod 5. isn’t just another bed-frame add-on; it’s a high-tech mattress cover that actively adjusts to your body temperature throughout the night, cooling, warming, and even elevating your body when needed, all based on real-time data. The new Pod 5 introduces for the first time, a hydro-powered blanket system, utilising the same technology as the cover to extend temperature regulation across your entire body, not just the mattress surface. Clinically proven to increase quality sleep by up to one hour each night, it’s basically like having an AI-powered sleep coach, personal thermostat, and advanced health tracker working for you while you rest.  Head on over to eightsleep.com/project100 and use the code PROJECT100 (that’s Project one-zero-zero) and get up to $550 off your very own Pod 5. Trust me, your body will thank you for this investment in better sleep.See omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** Dr. Andrei Tutoveanu  brings dual expertise as both a pharmacist and dentist to reveal the critical connection between oral health and longevity.  Your mouth isn't just about teeth—it's a gateway that can either protect or compromise your entire body's health as you age. We spoke about: • The surprising link between gum disease and Alzheimer's through chronic inflammation • Why your mouth is the "dirtiest orifice" and what that means for systemic health • How poor oral hygiene creates pathways for bacteria to reach your heart and brain • The diabetes-periodontal disease cycle that feeds on itself • Daily protocols: proper brushing technique, water picks vs. flossing, tongue scraping • Acid vs. sugar "insults"—when to brush and when to wait • Why dry mouth from alcohol and medications accelerates oral health decline. The all-new WHOOP is here — now 7% smaller with 14+ days of battery life. New features like Healthspan show how your daily habits are affecting your rate of aging — and now you can check your blood pressure straight from your wrist. If you’re serious about performance, longevity, and actual progress — this is it. Sign up for a one-month free trial at WHOOP.com — or visit join.whoop.com/mentored for one month off your annual membership fee.  Eight Sleep’s newest generation, Pod 5. isn’t just another bed-frame add-on; it’s a high-tech mattress cover that actively adjusts to your body temperature throughout the night, cooling, warming, and even elevating your body when needed, all based on real-time data. The new Pod 5 introduces for the first time, a hydro-powered blanket system, utilising the same technology as the cover to extend temperature regulation across your entire body, not just the mattress surface. Clinically proven to increase quality sleep by up to one hour each night, it’s basically like having an AI-powered sleep coach, personal thermostat, and advanced health tracker working for you while you rest.  Head on over to eightsleep.com/project100 and use the code PROJECT100 (that’s Project one-zero-zero) and get up to $550 off your very own Pod 5. Trust me, your body will thank you for this investment in better sleep.See omnystudio.com/listener for privacy information.

In this episode, Mark sits down with Neal Mercado, Chief Science Officer at Melrose, one of Australia’s leading wellness brands. With a background in pharmaceutical sciences and more than 15 years in product formulation and clinical research, Neal brings rare insight into how supplements are actually developed, tested, regulated, and sometimes compromised. Neal most recently advised on the creation of FUTURELAB, a product range dedicated to the science of ageing well. Together, they unpack what works, what doesn’t, and what consumers need to know in an industry crowded with noise. This is a grounded conversation about longevity, metabolic health, and why scientific rigour matters more than ever. In this episode, we cover: • How supplement products are formulated and regulated• The real risks of adulteration and misleading labels • What a Chief Science Officer actually does• The science behind berberine and metabolic health • Why resveratrol remains controversial• The biggest challenges facing the supplement industry• How FUTURELAB approaches ageing well differently• The rise of personalised health and precision medicine• Where longevity science is heading nextSee omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** I loved talking to these experts on Project 100 from all around the world, each bringing different backgrounds, experiences and perspectives. Who would you love for me to interview on Project 100 next? Here are some highlights from the standout episodes of the year: 0:00 – 10:45 — Gary Brecka10:46 – 24:57 — Jordan Sullivan (Fight Dietitian)24:58 – 32:06 — Dr Andy Galpin32:07 – 42:35 — Dr Steven Lu43:36 – 51:55 — Professor Sarah McKay51:56 – 1:04:43 — Dr Lila LandowskiSee omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** Dr. Oliver Cronin joins me to unpack the truth about gut health, cancer prevention, and longevity.A gastroenterologist with a Fulbright scholarship from NYU Langone and fellowship training at Westmead Hospital, Oliver has seen firsthand how lifestyle and environment are reshaping Australia’s health. We talk reflux, the rise in bowel cancer among young Australians, and why colonoscopies remain one of the most powerful tools for early detection. He explains how AI is transforming endoscopy, detecting pre-cancerous cells with remarkable accuracy, and how preventative health programs like Everlab are changing the game. We also discuss what’s in your control: diet, fibre, exercise, and the tough conversations around alcohol and lifestyle. This is an unfiltered look at what’s really going on inside your body and how small, consistent changes can make the biggest difference to how long and how well you live. One product I’ve recently added to my routine from the Bulk Nutrients range is their NMN Extend. It’s a science-backed blend of 10 powerful ingredients, including NMN, Resveratrol, and Hyaluronic Acid, designed to support everything from energy and muscle recovery, to skin hydration, joint health, and event mental clarity. Check out their NMN extend product here: https://www.bulknutrients.com.au/products/nmn-capsules Eight Sleep’s newest generation, Pod 5. isn’t just another bed-frame add-on; it’s a high-tech mattress cover that actively adjusts to your body temperature throughout the night, cooling, warming, and even elevating your body when needed, all based on real-time data. The new Pod 5 introduces for the first time, a hydro-powered blanket system, utilising the same technology as the cover to extend temperature regulation across your entire body, not just the mattress surface. Clinically proven to increase quality sleep by up to one hour each night, it’s basically like having an AI-powered sleep coach, personal thermostat, and advanced health tracker working for you while you rest.  Head on over to eightsleep.com/project100 and use the code PROJECT100 (that’s Project one-zero-zero) and get up to $550 off your very own Pod 5. Trust me, your body will thank you for this investment in better sleep. The all-new WHOOP is here — now 7% smaller with 14+ days of battery life. New features like Healthspan show how your daily habits are affecting your rate of aging — and now you can check your blood pressure straight from your wrist. If you’re serious about performance, longevity, and actual progress — this is it. Sign up for a one-month free trial at WHOOP.com — or visit join.whoop.com/mentored for one month off your annual membership fee. See omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** We all know water’s essential — but how safe is it, really? In this episode, I sit down with environmental scientist Professor Ian Wright to uncover what’s actually in Australia’s water, how it’s being treated, and what that means for your long-term health and longevity. From desalination plants and rural water systems to the growing threat of PFAS contamination, Professor Wright explains the hidden chemicals, the policies behind them, and how they can impact everything from your metabolism to disease risk. If you care about your health, your environment, and the future of clean water in Australia — this one’s for you. One product I’ve recently added to my routine from the Bulk Nutrients range is their NMN Extend. It’s a science-backed blend of 10 powerful ingredients, including NMN, Resveratrol, and Hyaluronic Acid, designed to support everything from energy and muscle recovery, to skin hydration, joint health, and event mental clarity. Check out their NMN extend product here: https://www.bulknutrients.com.au/products/nmn-capsules Eight Sleep’s newest generation, Pod 5. isn’t just another bed-frame add-on; it’s a high-tech mattress cover that actively adjusts to your body temperature throughout the night, cooling, warming, and even elevating your body when needed, all based on real-time data. The new Pod 5 introduces for the first time, a hydro-powered blanket system, utilising the same technology as the cover to extend temperature regulation across your entire body, not just the mattress surface. Clinically proven to increase quality sleep by up to one hour each night, it’s basically like having an AI-powered sleep coach, personal thermostat, and advanced health tracker working for you while you rest.  Head on over to eightsleep.com/project100 and use the code PROJECT100 (that’s Project one-zero-zero) and get up to $550 off your very own Pod 5. Trust me, your body will thank you for this investment in better sleep. The all-new WHOOP is here — now 7% smaller with 14+ days of battery life. New features like Healthspan show how your daily habits are affecting your rate of aging — and now you can check your blood pressure straight from your wrist. If you’re serious about performance, longevity, and actual progress — this is it. Sign up for a one-month free trial at WHOOP.com — or visit join.whoop.com/mentored for one month off your annual membership fee. See omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** Dr. Lila Landowski is a neuroscientist, lecturer at the University of Tasmania, and Vice President of Science & Technology Australia. In this episode, we unpack the science of stress and its impact on longevity. You’ll learn how chronic stress influences neurodegenerative disease, why not all stress is bad, and the mindset shifts that help build resilience. Dr. Landowski also shares practical tools to manage stress and improve sleep, the powerful role of social connection and prosocial behaviours, and the hidden downsides of alcohol and drugs in stress management. We also explore how continual learning and cognitive reserve can protect your brain as you age. If you want to understand how stress really affects your body and mind—and discover the science-backed tools to take control—this episode is a must-listen. One product I’ve recently added to my routine from the Bulk Nutrients range is their NMN Extend. It’s a science-backed blend of 10 powerful ingredients, including NMN, Resveratrol, and Hyaluronic Acid, designed to support everything from energy and muscle recovery, to skin hydration, joint health, and event mental clarity. Check out their NMN extend product here: https://www.bulknutrients.com.au/products/nmn-capsules   Eight Sleep’s newest generation, Pod 5. isn’t just another bed-frame add-on; it’s a high-tech mattress cover that actively adjusts to your body temperature throughout the night, cooling, warming, and even elevating your body when needed, all based on real-time data. The new Pod 5 introduces for the first time, a hydro-powered blanket system, utilising the same technology as the cover to extend temperature regulation across your entire body, not just the mattress surface. Clinically proven to increase quality sleep by up to one hour each night, it’s basically like having an AI-powered sleep coach, personal thermostat, and advanced health tracker working for you while you rest.  Head on over to eightsleep.com/project100 and use the code PROJECT100 (that’s Project one-zero-zero) and get up to $550 off your very own Pod 5. Trust me, your body will thank you for this investment in better sleep. The all-new WHOOP is here — now 7% smaller with 14+ days of battery life. New features like Healthspan show how your daily habits are affecting your rate of aging — and now you can check your blood pressure straight from your wrist. If you’re serious about performance, longevity, and actual progress — this is it. Sign up for a one-month free trial at WHOOP.com — or visit join.whoop.com/mentored for one month off your annual membership fee.   See omnystudio.com/listener for privacy information.