The Life Scientific

Imagine looking at a map of a city you thought you knew inside-out, only to discover a collection of tightly knit neighbourhoods that nobody had ever realised existed... Edith Heard has achieved something rather similar with DNA.Edith is a leading expert in epigenetics: put simply, the science around how our bodies can turn particular genes on or off without actually altering our DNA. She’s spent her career studying the mechanisms that make us who we are and transforming our understanding of how X chromosomes are expressed; notably, how female cells turn off the spare X chromosome.Talking to Professor Jim Al-Khalili, Edith discusses her journey from a shy and introverted youngster to the cutting edge of European science - including her latest role as Director of London’s prestigious Francis Crick Institute. Presented by Jim Al-Khalili Produced by Lucy Taylor A BBC Studios production

"My ideas are often labelled as impossible, or useless, or both. Usually when people say that I'm on the right track."George Church is a geneticist, molecular engineer, and one of the pioneers of modern genomics. He's also someone who makes a habit of finding solutions to the seemingly impossible.Over the course of his career so far, George developed the first method for direct genomic sequencing, helped initiate the Human Genome Project, and founded the Personal Genome Project: making huge quantities of DNA data publicly available for research. Today, as a professor at Harvard Medical School and MIT, he’s working on some of the most headline-grabbing - and controversial - science on the planet: from the so-called "de-extinction" of woolly mammoths, to growing transplant-suitable organs in pigs, to virus-proofing humans.When inspiration strikes, there seems to be little that will slow him down - even the fact that he has narcolepsy, the neurological disorder that causes sudden sleep attacks. In fact, as George tells Professor Jim Al-Khalili, some of his best ideas come in those moments between waking and sleep...Presented by Jim Al-Khalili Produced by Lucy Taylor for BBC Studios

Many people will be familiar with Parkinson’s disease: the progressive brain disorder that causes symptoms including tremors and slower movement, leading on to serious cognitive problems. You might not know that it’s the fastest-growing neurological condition in the world. Today it affects around 11.8 million people and that’s forecast to double by 2030. Dr Sonia Gandhi is one of the scientists working to change that trend. As Professor of Neurology at University College London and Assistant Research Director at the Francis Crick Institute, her work involves using stem cells to build models of the human brain, helping to drive the development of drugs and other therapies for Parkinson’s patients.Talking to Professor Jim Al-Khalili, Sonia explains why this destructive condition is on the rise - and the promising routes they're studying to find new ways to tackle it.Presented by Jim Al-Khalili Produced by Lucy Taylor for BBC StudiosFor details of organisations that offer advice and support to anyone affected by Parkinson's Disease, please go online to bbc.co.uk/actionline.

There can't be many people in the world who've saved lives in hospital emergency rooms and also helped care for the wellbeing of astronauts in space – but Kevin Fong’s career has followed a singular path: from astrophysics and trauma medicine, to working with NASA, to becoming an Air Ambulance doctor.Kevin is a consultant anaesthetist and professor of public engagement and innovation at University College London. He’s worked on the front line in hospitals, dealing with major incidents and helping shape policy; but he's also stayed true to his childhood passion for space, working on multiple projects with NASA and even going through the astronaut application process himself. As if that wasn’t enough, he’s also become a well-known figure in science broadcasting through his various radio and TV shows.Speaking to Professor Jim Al-Khalili, Kevin admits it hasn't always been an easy path – but his passion for both space and medicine have got him through. And today, he's channelling his energies into ensuring we protect the NHS's most precious commodity: its staff.Presented by Jim Al-Khalili Produced by Lucy TaylorThis programme was a BBC Studios Audio prouction for Radio 4.

Have you ever considered the lighter side of dark matter? Comedy has proved an unexpectedly succesful way to engage people with science - as today's guest knows first-hand. Astrophysicist Catherine Heymans is a Professor at the University of Edinburgh and the current Astronomer Royal for Scotland. She’s spent her career studying dark matter and dark energy: the mysterious ingredients that make up an estimated 95% of our cosmos, but which we still know surprisingly little about. Using increasingly powerful telescopes, both on earth and in space, Catherine has spent years building detailed maps of dark matter - even to the extent of capturing rare images of this mysterious cosmic component.On top of her research achievements, she's committed to making science accessible to all; not least by taking an astronomy-themed comedy show to the Edinburgh Festival and beyond. In conversation with Professor Jim Al-Khalili, Catherine talks about her passion for sharing the joys of astrophysics - and reveals how health challenges over the last few years have forced her to readdress her career, her ambitions and even her sense of self... Presented by Jim Al-Khalili Produced by Lucy Taylor