Feeling Stuck on Antidepressants in Midlife? How to Taper Off Safely with Mark Horowitz, PhD

Feeling Stuck on Antidepressants in Midlife? How to Taper Off Safely with Mark Horowitz, PhD

From BETTER! with Dr. Stephanie Estima | Strength, Body Composition & Perimenopause by Dr. Stephanie Estima, Perimenopause & Women's Fitness Expert

March 23, 2026 · 1h 26m

About this episode

Dr. Mark Horowitz discusses the long-term effects of antidepressants and how to taper off safely.

56 million Americans are on antidepressants — and 25 million have been for more than five years. Psychiatry researcher and de-prescribing expert Dr. Mark Horowitz unpacks what antidepressants are actually doing to your brain and body over the long term, including effects on mood, weight, sleep, memory, and sexual function. Watch the full episode at https://youtu.be/30Y9eMEqltA

People in this episode

Host: Dr. Stephanie Estima

Guest: Mark Horowitz

Topics covered

  • antidepressants
  • mental health
  • de-prescribing
  • midlife
  • psychiatry
  • brain health

Keywords

  • antidepressants
  • tapering off
  • mental health
  • midlife
  • de-prescribing
  • psychiatry
  • brain
  • mood
  • sleep
  • memory

Mentioned in this episode

Organizations: YouTube

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