Gladden Longevity Podcast

In this episode of the Gladden Longevity Podcast, Dr. Gladden and Leslie Kenny delve into the intricacies of aging, health, and the role of spermidine in promoting longevity. They discuss the hallmarks of aging, Leslie's personal journey with autoimmune conditions, and the importance of empowerment and curiosity in health management. The conversation emphasizes the interconnectedness of health factors and the need for a holistic approach to wellness. In this conversation, Leslie Kenny and Dr. Gladden explore the potential of spermidine as a breakthrough in aging research, discussing its effects on health, longevity, and cellular processes like autophagy. They share personal experiences with spermidine, the challenges of clinical research, and the importance of redefining aging. The conversation also highlights resources for healthy aging and the significance of mindset in health management. For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/! Takeaways · Spermidine positively impacts multiple hallmarks of aging. · Crosstalk between hallmarks of aging can enhance health. · Mindset plays a crucial role in health outcomes. · Patients should collaborate with their healthcare providers. · Curiosity in medicine leads to better patient outcomes. · The healthcare system often lacks time for curiosity. · Empowerment in health management is essential. · Modulating the immune system can restore balance. · Personal experiences can lead to significant health insights. · Holistic approaches to health can yield better results. Spermidine activates autophagy, aiding in cellular renewal. · Chronic management of illnesses is not desirable; patients want solutions. · Biological age can be significantly lower than chronological age. · Spermidine has potential benefits for heart health and cognition. · Personal experiences with spermidine show promising results in sleep quality. · Clinical trials for food-derived compounds face financial challenges. · The body can adapt and respond positively to the right inputs. · Redefining aging is crucial for a healthier future. · Mindset plays a vital role in health and aging. · Resources like Oxford Health Span can provide valuable information. Chapters 00:00 Introduction to Longevity and Health 05:23 The Role of Spermidine in Aging 08:52 Personal Journey with Autoimmune Conditions 12:34 Empowerment in Health Management 18:07 The Importance of Curiosity in Medicine 25:21 Finding Balance in Immune Health 31:32 The Quest for Longevity and Health 34:58 Spermidine: A Breakthrough in Aging Research 39:14 Personal Experience with Spermidine 44:40 Challenges in Clinical Research 49:52 Redefining Aging and Health 52:52 Resources for Healthy Aging To learn more about Leslie Kenny: Instagram: https://www.instagram.com/lesliesnewprime/ Website: oxfordhealthspan.com, lesliesnewprime.com Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

In this episode of the Glad and Longevity Podcast, Jeff Gladden and Jonathan Roseland delve into the world of biohacking and nootropics. They discuss the inspiration behind Roseland's journey into cognitive enhancement, the quest for effective smart drugs, and the role of nicotine in boosting creativity. The conversation also touches on the importance of a systems biology approach to personal development, emphasizing the need for personalized strategies in optimizing cognitive function and overall health. In this conversation, Jonathan Roseland and Jeff Gladden explore the themes of risk-taking, spirituality, psychedelics, and memory enhancement. They discuss the importance of embracing risk in various aspects of life, the spiritual dimensions of longevity, and the potential benefits of psychedelics for personal growth. Additionally, they delve into effective memory enhancement techniques and the power of the mind in shaping personal agency and identity. For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/! Takeaways Nootropics can provide instant motivation and clarity. The quest for effective smart drugs is ongoing. Nicotine is recognized as a creativity enhancer. Personal development often requires a systems biology approach. Finding your edge is essential for personal growth. Racetams are a promising class of nootropics. Biohacking can lead to meaningful personal development. Understanding individual biodiversity is crucial in nootropic use. Living young for a lifetime involves taking calculated risks. Systems biology can streamline the process of finding effective nootropics. Finding your edge in life can lead to growth. Embracing risk is essential for learning and joy. Spiritual practices contribute to longevity and well-being. Psychedelics can facilitate profound personal insights. Memory enhancement techniques can significantly improve recall. The mind operates on both conscious and subconscious levels. Self-love and safety are crucial for personal development. Agency over one's life choices is empowering. Engaging in challenging activities keeps the mind sharp. Personal growth often requires stepping outside of comfort zones. Chapters 00:00 Introduction to Biohacking and Nootropics 05:57 The Quest for Smart Drugs 12:05 Nootropics: Instant Motivation and Clarity 17:55 Exploring Racetams and Their Effects 23:45 The Role of Nicotine in Cognitive Enhancement 30:05 Systems Biology Approach to Personal Development 37:27 Riding the Edge: Embracing Risk in Life 45:40 The Spiritual Dimension of Longevity 51:39 Psychedelics and Spiritual Growth 58:32 Memory Enhancement Techniques 01:11:36 The Power of the Mind and Personal Agency To learn more about Jonathan Roseland:Email: jr@limitlessmindset.com Website: https://www.limitlessmindset.com/ Facebook: https://www.facebook.com/limitlessmindset Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden speaks with Nicole Bell and Jennifer Miller from Galaxy Diagnostics about the challenges and advancements in diagnosing and treating tick-borne illnesses, particularly Lyme disease. They discuss the personal journey that led Nicole to become the CEO of Galaxy Diagnostics, the complexities of the immune response to Lyme, and the innovative diagnostic approaches being developed to improve patient outcomes. The conversation also touches on the implications of co-infections and the future of research in this critical area of health. For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/! Takeaways · Nicole Bell's personal experience with tick-borne illness led her to Galaxy Diagnostics. · Lyme disease can be misdiagnosed, leading to severe consequences. · The immune response to Lyme is complex and can lead to chronic inflammation. · Genetic predispositions can affect how individuals respond to tick-borne pathogens. · Innovative diagnostic methods are being developed to improve detection of Lyme and co-infections. · Urine samples can be effective for diagnosing Lyme disease. · Co-infections like Bartonella can complicate treatment and diagnosis. · Early diagnosis is crucial for effective treatment of tick-borne illnesses. · Research is ongoing to better understand the relationship between tick-borne pathogens and mental health. · Galaxy Diagnostics aims to change the standard of care for tick-borne illnesses. Chapters 00:00 Introduction to Tick-Borne Illnesses 05:04 The Journey of Diagnosis and Treatment 09:50 Understanding Lyme Disease and Its Challenges 14:53 The Immune Response and Genetic Factors 19:54 Innovative Diagnostic Approaches 24:53 Co-Infections and Their Implications 29:55 The Future of Tick-Borne Pathogen Research To learn more about Nicole Bell/Galaxy Diagnostics:Email: nicole.bell@galaxydx.com Website: https://www.galaxydx.com/ Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

In this episode, Dr. Gladden and nutrition expert Sarah Kennedy discuss Calocurb, a natural extract that uses evolutionary biology to suppress appetite. The discovery focuses on bitter taste receptors (T2Rs) located throughout the gastrointestinal tract, which historically served as a protective mechanism to slow the consumption of potentially toxic substances. By using a specific New Zealand hop extract, Calocurb triggers these receptors to signal the brain that the body is full. This process stimulates the natural release of satiety hormones—GLP-1, CCK, and PYY—effectively quieting "hunger noise" and reducing caloric intake without the need for synthetic pharmaceuticals. For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/! Takeaways · Sarah Kennedy transitioned from veterinary medicine to nutrition. · Calocurb is based on the hypothesis of appetite suppression through bitter taste receptors. · Bitter taste receptors are present throughout the gastrointestinal tract. · The primary hormones involved in appetite suppression are CCK, GLP-1, and PYY. · Clinical studies showed an 18% reduction in calorie intake with Calocurb. · Calocurb has a duration of action of four to six hours. · 5% of users may experience a laxative effect as a side effect. · The product can be used intermittently for weight management. · Future research will explore the effects of Calocurb on adolescents and gut health. · Calocurb is a natural alternative to synthetic appetite suppressants. Chapters 00:00 Introduction to Calocurb and Sarah's Background 02:52 The Science Behind Appetite Suppression 05:56 Mechanisms of Action: Hormones and Receptors 08:55 Clinical Studies and Results of Calocurb 11:50 Long-term Effects and Usage Recommendations 14:57 Side Effects and Adaptation 17:57 Future Research and Development Plans 21:01 Conclusion and Where to Find Calocurb To learn more about Sarah Kennedy: Facebook: https://www.facebook.com/calocurbGLOBAL/ Instagram: https://www.instagram.com/calocurb Website: www.calocurb.com Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

In this episode, I break down the six developments I'm watching in longevity for 2026 and why I believe we're closer than ever to cracking the code on aging. I explain how AI is already transforming personalized medicine (and how to prompt it for better results), introduce the Longevity Wingman app we're building to remove all friction from your health journey, and discuss why genetic testing is finally becoming truly actionable. I also cover the sequencing strategy behind regenerative procedures that most clinics get wrong, why nervous system optimization and shadow work may be the most underrated lever in longevity, and how quantum computing will change biology forever. If you stay for the last one, you'll understand why I think we're the luckiest generation of all time. For Audience · Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ ! Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now Takeaways · AI is becoming an integral part of health management. · The Longevity Wingman app aims to streamline health journeys. · Genetic testing is evolving to provide more actionable insights. · Optimizing regenerative procedures can significantly improve outcomes. · Understanding the nervous system is crucial for longevity. · Quantum computing may revolutionize biological analysis. · Personalized health strategies will become more accessible. · The integration of technology will reduce friction in health management. · Longevity practices are becoming more data-driven and customized. · The future of health looks promising with emerging technologies. Chapters 00:00 We're about to crack the code on aging... 00:18 AI is building custom supplement stacks for individual patients now... 02:57 An app that removes every friction point from your longevity journey... 05:22 Your genes aren't your destiny... they're just tendencies you can manipulate... 06:56 Most regenerative procedures only get 40% of their potential results... 09:24 All of life comes down to one thing... your nervous system... 09:59 If you don't identify what's in the shadow you'll call your life fate... 13:25 Quantum computing will test millions of biological solutions simultaneously... 14:55 We're the luckiest generation of all time... Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden sits down in person with fitness and nutrition expert Autumn Calabrese to unpack the full truth about GLP-1 agonists. With millions of people jumping on semaglutide, tirzepatide, and soon retatrutide, the conversation most doctors aren't having is about what's actually happening inside the body while the scale goes down. Dr. Gladden breaks down how GLP-1s suppress hunger, slow metabolism, and trigger muscle wasting when used without proper diagnostics or a supporting protocol. He explains the critical differences between GLP-1s, GLP-2s, and GLP-3s, reveals why the ghrelin rebound causes most people to regain everything they lost, and shares the strategies he uses in his practice to help patients lose fat while protecting lean tissue. From the 5-day fasting mimicking diet to natural GLP-1 boosters like metabolic probiotics and calocurb, this episode lays out a smarter, more sustainable path to optimizing body composition. Whether you're considering a GLP-1, already on one, or looking for alternatives, this is the conversation that could change your entire approach. For Audience • Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/! • Subscribe to the Gladden Longevity Newsletter for the latest on longevity medicine, peptide protocols, and hormone optimization → https://start.gladdenlongevity.com/subscribe • Ready to find out what's really going on inside your body? Book a call with the Gladden Longevity team → https://start.gladdenlongevity.com/apply-now Takeaways • Peptides are signaling partners, not substitutes for the work your body needs to do. • GLP-1s were designed for diabetics and metabolic syndrome, not casual weight loss. • GLP-1s decrease energy expenditure while GLP-3s (retatrutide) increase it. • Many GLP-1 users are losing muscle mass instead of fat without realizing it. • The ghrelin rebound after stopping a GLP-1 drives appetite higher than before while metabolism stays slower. • A fasting blood sugar and hemoglobin A1C alone are not enough to understand your metabolic health. • A two-hour glucose tolerance test with an insulin curve reveals insulin resistance most doctors completely miss. • The 5-day fasting mimicking diet resets ghrelin, taste buds, gut biome, and leptin sensitivity without destroying muscle. • You can boost your body's own natural GLP-1 production through the right probiotics and bitter receptor activation. • Weight gain is not always an appetite problem. Thyroid dysfunction, declining sex hormones, and missing micronutrients can all be the real driver. • Sex hormone optimization during perimenopause and andropause is critical for maintaining body composition. • Willpower never wins long term. Systems and environment design are what create durable results. Chapters 00:00 Introduction and Welcome with Autumn 00:44 What Is a Peptide and How Peptides Work in the Body 03:07 BPC-157 and the Pharma Model vs. Peptide Signaling 05:00 You Can't Out-Peptide Bad Habits 06:31 What Is a GLP-1 and How It Affects Your Brain and Gut 08:57 GLP-1s Were Designed for Diabetics Not Weight Loss 09:40 GLP-2 Tirzepatide and GLP-3 Retatrutide Explained 11:00 Why Retatrutide Increases Energy Expenditure While GLP-1s Decrease It 12:00 The Muscle Mass Crisis on GLP-1s 14:06 The Patient Who Lost 20 Pounds of Pure Muscle 15:00 Protecting Muscle with Perfect Aminos and Creatine 17:00 Autumn's Personal Supplement Stack for Training 19:00 Food Noise Ghrelin and the Appetite Rebound 21:18 The 5-Day Fasting Mimicking Diet as a Metabolic Reset 23:00 Building Your Own Natural GLP-1 Production 25:00 The Glucose Tolerance Test Most Doctors Never Run 28:30 Risks of GLP-1s Pancreatitis Thyroid Tumors and Unsupervised Use 29:50 Microdosing GLP-1s in Perimenopause 30:30 Calocurb the Natural Appetite Suppressant from Hops 32:00 Sex Hormone Optimization for Body Composition 35:00 Resting Metabolic Rate Testing and Hidden Thyroid Dysfunction 38:00 Autumn's Hormone Health Program and Real Results 39:30 Willpower vs Systems and Architecting Your Environment 41:30 Bio-Individuality and Why Someone Else's Plan Won't Work for You 43:00 The Power of Diagnostics and Understanding Your Genetics To learn more about Autumn: Instagram: @autumncalabrese Reach out to us at: Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden speaks with Dr. Anthony Beck about the evolving landscape of functional medicine and the importance of personalized health approaches. They discuss the challenges patients face in navigating conflicting health information, the significance of integrating multiple health assessments, and the role of genetics in understanding individual health. Dr. Beck emphasizes the need for collaboration among healthcare providers and the empowerment of patients in their health journeys, advocating for a comprehensive and individualized approach to wellness. For Audience · Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ ! Takeaways · Dr. Beck emphasizes the importance of a comprehensive approach to health. · Personal experiences often shape a practitioner's journey in medicine. · Functional medicine is evolving and adapting to new challenges. · Patients often face conflicting information in the health space. · Understanding personal health data is crucial for effective treatment. · Integrating multiple health assessments provides a clearer picture. · Genetics play a role, but they don't dictate health outcomes. · Social media can complicate health information and trends. · Collaboration among healthcare providers enhances patient care. · Empowering patients to take charge of their health is essential. Chapters 00:00 Introduction to Longevity and Education 03:38 Personal Journey and Background of Dr. Beck 07:49 Transitioning to Functional Medicine 10:54 Navigating the Information Overload 14:35 The Importance of Individualized Medicine 18:22 Creating a Comprehensive Testing Framework 21:10 Understanding Genetic Testing and Personalized Medicine 24:14 The Importance of Foundational Health Data 27:10 Navigating the Longevity Space: Myths and Realities 31:19 The Complexity of Health: Beyond Simple Solutions 33:54 The Role of Collaboration in Patient Care 37:51 Empowering Patients: Taking Control of Health Decisions To learn more about Dr. Anthony Beck: Email: dragb@dranthonygbeck.com Website: balanceprotocol.com Instagram: https://www.instagram.com/balanceprotocol Facebook: https://www.facebook.com/balanceprotocol Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden engages in a heartfelt conversation with Elizabeth, Karen, and Mukti about the profound journey of grief and healing. Elizabeth shares her personal story of losing her husband and the subsequent struggle with despair, highlighting the importance of community support and coaching in her recovery. Karen provides insights into the role of grief education and the need for proactive approaches to healing. Mukti discusses the significance of understanding grief through a broader lens, emphasizing the importance of community in the healing process. Together, they explore themes of resilience, transformation, and the coexistence of grief and joy, ultimately inspiring listeners to embrace their own journeys of healing and growth. For Audience · Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ ! Takeaways · Elizabeth shares her journey from grief to healing. · The importance of community support in overcoming loss. · Karen emphasizes the need for proactive grief education. · Mukti discusses the role of psychedelics in grief therapy. · Resilience is key to navigating life's challenges. · Elizabeth highlights the transformative power of coaching. · The significance of feeling emotions in the healing process. · Grief can coexist with joy in a person's life. · The anti-fragile mindset allows for growth through adversity. · Creating a supportive community is essential for healing. Chapters 00:00 Journey Through Grief: Elizabeth's Story 11:56 Finding Hope: The Role of Community and Support 18:15 Transformative Healing: Karen's Impact on Elizabeth 23:47 Living with Love: Honoring Loss and Moving Forward 25:11 Understanding Grief and Mourning 30:03 The Journey of Healing and Transformation 36:03 The Hero's Journey of Reclaiming Life 40:36 Community and Support in Healing 49:23 Embracing Darkness as a Teacher To learn more about Karen Sutton: Email: coaching@karensutton.co.uk Website: https://www.karensutton.co.uk/ Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.