The Health Upgrade Podcast

NAD+ is usually described as something you run out of. JP Errico explains why that's backwards: you don't stop making it, you burn through it — and inflammation is what's doing the burning.In this episode, we cover what NAD+ actually does beyond energy production, why sirtuins can't function without it, and how CD38 on activated immune cells consumes NAD+ by the thousands of molecules. JP walks through SIRT1 and its control over NF-κB, PGC-1α and FOXO3; SIRT3's role in mitochondrial protein folding and heat shock proteins; and SIRT6's work in DNA damage repair.We also get into a CD38 vaccine coming out of China, how your body packages the NAMPT recycling enzyme into exosomes and ships it to the cells that need it while you sleep, where urolithin A and methylene blue fit, and why no supplement can out-run a broken circadian rhythm.JP closes with the four root causes of aging — mitochondrial electron transport chain malfunction, chronic NF-κB activation, AMPK and mTOR imbalance, and NAD+ depletion — and why every one of them is reversible.In this episode, we discuss:Why NAD+ decline is a consumption problem, not a production problemPARP1, CD38, and what's actually draining the tankWhat sirtuins do, and why they stop working without NAD+SIRT1, SIRT3, SIRT6 — and which has the best longevity dataNMN vs NR: why the debate matters less than you thinkSleep, fasting, heat and exercise as the foundationThe four reversible root causes of agingHow perception changes whether a challenge ages you or strengthens you Dr. Navaz HabibEmail: [email protected]: https://www.facebook.com/DrNavazHabib/Instagram: https://www.instagram.com/drnavazhabib/LinkedIn: https://ca.linkedin.com/in/drnavazhabibJP ErricoInstagram: https://www.instagram.com/thevnsguy/LinkedIn: https://www.linkedin.com/in/jp-errico-097629aa

In this episode of the Health Upgrade Podcast, I dive into the growing epidemic of blood sugar dysregulation and type 2 diabetes, breaking down why these issues have become so prevalent. I explain how genetics, lifestyle, stress, sleep, and even our gut microbiome all play a critical role in blood sugar regulation, not just the foods we eat. From genetic markers to the impact of adverse childhood events, I highlight the interconnectedness of our environment and our metabolic health.You will learn about effective strategies for blood sugar management, from optimizing meal timing and movement to choosing the best evidence-backed diets and supporting gut health. I share simple, actionable tips like walking after meals, prioritizing quality sleep, and building consistent exercise routines, emphasizing that consistency, not perfection, is the key to long-term results.If you found these insights helpful, please share this episode with friends who might benefit from a health upgrade too! Let’s work together to make small, sustainable changes for better health! Dr. Navaz HabibEmail: [email protected]: https://www.facebook.com/DrNavazHabib/Instagram: https://www.instagram.com/drnavazhabib/LinkedIn: https://ca.linkedin.com/in/drnavazhabib

In this special “Ask Us Anything #2” episode of the Health Upgrade Podcast, Valerie Driscoll and Sara Tate join me to answer questions from our Health Upgraded community.We talk about what can happen when you start vagus nerve stimulation too early and why it’s important not to introduce too many new treatments or tools before your body is ready.We also discuss the importance of checking the basics first, including digestion, bowel movements, hydration, stress levels, and healthy ways to cope with stress. Before trying more advanced tools like stimulators or cold plunges, it’s important to make sure your body has a strong foundation.If you enjoyed the conversation, share the episode with someone who might find it helpful. Remember, good health starts with getting the basics right before adding more to your routine.Dr. Navaz HabibEmail: [email protected]: https://www.facebook.com/DrNavazHabib/Instagram: https://www.instagram.com/drnavazhabib/LinkedIn: https://ca.linkedin.com/in/drnavazhabib