To Health With That! MTHFR Mutations and Methylation.

KC was kind enough to share her story of MTHFR, POTs, or postural orthostatic tachycardia syndrome. This was a long interview, so it has been broken up into two podcast episodes. 00:49 - Meet KC01:18 - POTS diagnosis02:07 - POTS and COVID-1902:58 - POTS and MTHFR 06:22 - Giving up folic acid06:49 - Symptoms of folic acid detox07:17 - Methylated vitamins09:03 - Health knowledge is power09:18 - Understanding your genes for your kids10:06 - POTS, Acupuncure and DNRS11:11 - POTS and anxiety11:44 - POTS and altitude13:02 - POTS is underdiagnosed13:30 - POTS symptoms14:22 - Internet medical researchThanks so much for watching! I have so many other resources for you. Here is the full-length version of this interview: https://youtu.be/fveJ32ZO-OECheck out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ Order Dr. Amy's book MTHFR Easy: Get Healthy For Life: https://amzn.to/47tT31YPaperback and audiobook versions are coming soon.This story was graciously shared with permission to post on the podcast, YouTube, and in print, if that happens in the future.

Monica was kind enough to share her health story with us, starting with a PCOS diagnosis, then thyroid antibodies, then uncontrollable hives, and finally to some relief when she found out about MTHFR and started working on her methylation. This is the full-length interview. MTHFR stories have so much variety, but there are common threads and hormone imbalance, inflammation, and histamine are definitely in there. Thank you so much for being here, Monica!00:00 - Intro and Monica’s PCOS diagnosis01:54 - Hives02:23 - Head to toe Hives02:45 - I’m scared of food03:26 - Discovering MTHFR04:36 - Monica’s supplements06:04 - Folinic acid and anxiety07:25 - Grieving all the time I didn’t know about MTHFR08:06 - Protecting her children’s health09:23 - Eating healthy without overwhelm10:24 - The most helpful things for Monica10:55 - Nervous system health and self-time11:26 - Hives latelyHere is the full-length interview on YouTube.Thank you so much to Monica, who consented to share this content on the podcast and on YouTube.Thanks so much for watching. Here are some links that you might like.The website (and lots of free resources): ⁠https://tohealthwiththat.com⁠FREE MTHFR Basics course: ⁠https://www.tohealthwiththat.com/free-tools⁠

Christa generously shares the story of how discovering MTHFR and detoxifying completely changed the trajectory of her son's life, and their family's attention to nutrition. Christa's son struggled with communication, attention, memory, sensory issues, and what was diagnosed as developmental delay. Thanks to Christa's hard work with eliminating folic acid and using detoxification support, including zeolites, her son is now thriving.00:00 - Introduction and meet Christa00:49 - Christa's son's struggles - communication, sensitivity, and developmental delay01:39 - The day we knew things weren't normal02:00 - Mom says "This is on me."02:31 - Finding out about MTHFR03:11 - Starting to detox03:29 - Three weeks of no folic acid and zeolites and he was a different kid.03:55 - MTHFR testing comes back positive04:19 - "I've been poisoning my son with fortified foods his whole life"04:40 - He's not struggling, but he's not thriving yet05:35 - I wish every mom knew about this07:02 - No more special needs or developmental delay.08:04 - The ability to express himself08:45 - Getting folic acid out of the way09:31 - Why babies should be tested for MTHFR10:12 - The complicated case of fortified food10:40 - Raising awareness to help other parents11:09 - Making changes for Max has helped the whole householdThanks so much for watching! I have so many other resources for you. Here is the full length version of this interview: https://youtu.be/FVbXxD9WVoQIf you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: ⁠https://calendly.com/amy-tohealthwiththat/new-meeting⁠Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ Order Dr. Amy's book MTHFR Easy: Get Healthy For Life: https://amzn.to/47tT31YPaperback and audiobook versions are coming soon.This story was shared graciously and generously with permission to post on the podcast, Youtube, and in print if that happens in the future.

Season 5, Episode 7 of the To Health With That! podcast. Betsy and I recorded this video several years ago (hence the hair!) and she was kind enough to consent to share it in this format as well. Betsy's history as a nurse gives her a wonderful, insightful perspective on healthcare and her journey with autoimmune disease and having to take an antifolate will help so many other individuals who are struggling with this issue.00:00 - Intro00:36 - Betsy’s Story with Autoimmune disease03:20 - Flexibility is Betsy’s most important thing04:51 - Highly Sensitive People05:36 - MTHFR and perfectionism06:53 - Personal responsibility in MTHFR07:21 - Taking methotrexate with MTHFR (an anti-folate medication)09:11 - Symptom tracking10:53 - Knowledge about your own health is power.Thanks so much for watching! I have so many other resources for you. Here is the full version of this interview: If you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: ⁠https://calendly.com/amy-tohealthwiththat/new-meeting⁠Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ Order Dr. Amy's book MTHFR Easy: Get Healthy For Life: https://amzn.to/47tT31YPaperback and audiobook versions are coming soon.This story was shared graciously and generously with permission to post on the podcast, Youtube, and in print if that happens in the future.

To Health With That! Podcast Season 5, Episode 5. Thank you so much to Tony for generously sharing his story - the full interview was fabulous and included much more than we could put in one podcast episode, so we broke it into two. In this episode, Tony continues to share with the idea of MTHFR being a rebirth, new information he has about a tumor and his concerns about folate and tumor growth, and questions about MTHFR and anesthesia.00:00 - Introduction00:43 - Manageable steps01:07 - Symptom tracking01:23 - Staying in control (or not).02:03 - MTHFR as a rebirth02:45 - tumor03:10 - folate and tumor growth04:40 - Do we get enough B12 from food06:15 - B12 and lithium rotate07:15 - MTHFR and detox09:42 - mental health struggles and folic acid10:31 - MTHFR and anesthesia11:11 - MTHFR and nitrous oxide and preparing for surgery12:32 - MTHFR and antibiotics13:33 - Building back good gut floraThanks so much for watching! I have so many other resources for you. Here is the full version of this interview: https://youtu.be/SZmHnyCKd8UIf you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: ⁠https://calendly.com/amy-tohealthwiththat/new-meeting⁠Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ You can now Pre-order the book MTHFR Easy: Get Healthy For Life. https://www.amazon.com/MTHFR-Get-Started-Guide-Healthy-ebook/dp/B0FLFCY1YQ/ref=sr_1_2?crid=3E616JJOYSA12&dib=eyJ2IjoiMSJ9.7WXbrOZ6vkAu5Ncg9lJLavpPvim_O1kOvqp3LTim_snTq6Gahvu-NhWvC1mZurA6.XnOpY_FYGI_DbfEx9NmEwRrSM2USTXkw_HTykBFrMtw&dib_tag=se&keywords=amy+neuzil&qid=1755710249&sprefix=amy+neuzil%2Caps%2C98&sr=8-2 Look for Kindle, audiobook, and paperback versions also to be released on October 24, 2025.GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): https://community.tohealthwiththat.comThis story was shared graciously and generously with permission to post on the podcast, Youtube, and in print if that happens in the future.

Thank you so much to Karene for generously sharing her story! Karene is new to MTHFR - she just found out that she and her children have an MTHFR gene mutation one week ago. Karene tested because of ADHD for herself and one of her sons, and is just starting to learn about the gene SNP and what to do. 00:30 - Introducing Karene01:03 - ADHD diagnosis01:39 - Why MTHFR explains so much for her son02:14 - MTHFR and ADHD02:47 - Methyl folate start02:14 - Trying to make sense of all the information04:01 - Diet and fortified foods with MTHFR05:04 - The folate issue06:19 - Dairy and MTHFR06:36 - MTHFR and overload07:13 - MTHFR and HSP07:51 - Interest in healthy eating is what we can leave our children when we die08:53 - What is the right dose of methyl folate09:42 - Methyl folate and the ADHD brain10:17 - Zeolites for detox in kids10:48 - Methyl folate supplements and doses11:57 - Does methyl folate build up?12:20 - Weekends off of supplements13:17 - BlessingsThanks so much for watching! I have so many other resources for you. Here is the full version of this interview: https://youtu.be/Gsj3F-9g55wIf you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: ⁠https://calendly.com/amy-tohealthwiththat/new-meeting⁠Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ You can now Pre-order the book MTHFR Easy: Get Healthy For Life. https://www.amazon.com/MTHFR-Get-Started-Guide-Healthy-ebook/dp/B0FLFCY1YQ/ref=sr_1_2?crid=3E616JJOYSA12&dib=eyJ2IjoiMSJ9.7WXbrOZ6vkAu5Ncg9lJLavpPvim_O1kOvqp3LTim_snTq6Gahvu-NhWvC1mZurA6.XnOpY_FYGI_DbfEx9NmEwRrSM2USTXkw_HTykBFrMtw&dib_tag=se&keywords=amy+neuzil&qid=1755710249&sprefix=amy+neuzil%2Caps%2C98&sr=8-2 Look for Kindle, audiobook, and paperback versions also to be released on October 24, 2025.GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): community.tohealthwiththat.comThis story was shared graciously and generously with permission to post on the podcast, YouTube, and in print if that happens in the future.

Lisa's story is a testament to what having a community of people can do for your health journey. Lisa touches on many familiar MTHFR issues - allergies, impatience, food sensitivities, blood sugar imbalance, struggles with weight, lip tie, and perfectionism. Her biggest hurdles on this journey have been about self-acceptance and also learning to have patience and not over-push her body. She is sharing those lessons with her children and grandchildren in a way that is so inspiring for all of us with MTHFR.OO:41 - Lisa's health journey02:17 - Learning patience02:37 - One step at a time03:07 - Signs of MTHFR in the family tree04:01 - Highly Sensitive Person (HSP)05:12 - The power of community05:55 - Restaurant food and food sensitivities08:23 - Blood sugar and weight loss10:00 - Accepting yourself11:07 - Trust yourselfThanks so much for watching! I have so many other resources for you. Here is the full-length version of this interview: https://youtu.be/WJkUGiMWMXYIf you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: https://calendly.com/amy-tohealthwiththat/new-meetingCheck out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ You can now Pre-order the book MTHFR Easy: Get Healthy For Life. https://www.amazon.com/MTHFR-Get-Started-Guide-Healthy-ebook/dp/B0FLFCY1YQ/ref=sr_1_2?crid=3E616JJOYSA12&dib=eyJ2IjoiMSJ9.7WXbrOZ6vkAu5Ncg9lJLavpPvim_O1kOvqp3LTim_snTq6Gahvu-NhWvC1mZurA6.XnOpY_FYGI_DbfEx9NmEwRrSM2USTXkw_HTykBFrMtw&dib_tag=se&keywords=amy+neuzil&qid=1755710249&sprefix=amy+neuzil%2Caps%2C98&sr=8-2 Look for Kindle, audiobook, and paperback versions also to be released on October 24, 2025.GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): community.tohealthwiththat.comThis story was shared graciously and generously with permission to post on the podcast, Youtube, and in print if that happens in the future.

In the last episode, we talked about CBD as a methylation adaptogen, but we haven' talked too much about that term so let's dive in. We know that everyday methylation is important for people with the MTHFR gene or with any methylation dysfunction, but it turns out that long-term methylation care is important too and this can be achieved by getting methylation adaptogens.Methylation adaptogens are substances that help to regulate the amount your genes are methylated. Remember that when genes are methyalted, they are turned off and when they are unmethylated they are turned on. So having stretches of your genome that are undermethylated means the genes in there are allowed to function out of control, and that could lead to bigger problems like cancer.Methylating your genes appropriately is one of the long-term ways to prevent disease and even benefit your children, because research has shown that the way you methylate your genes might pass to your children. Not just the genes themselves, but the methylation tags.The most researched compounds that have been called methylation adaptogens come from food sources - things like caffeic acid from coffee and cruciferous veggies, lycopene from tomatoes and watermelon, resveratrol from red wine. Thanks so much for watching! I have so many other resources for you. Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): community.tohealthwiththat.com

Methylation imbalance and the causative factors leading to methylation imbalance, like the MTHFR gene mutation, show themselves in four distinct personality types. These methylation personality types, methylation archetypes, or MTHFR personalities are called The Achiever, The Athlete, The Activist, and The Artist.The Activist and The Artist are very closely linked. Neither are terribly ambitious or driven, except in the thing that matters to them, whether it's their art, their job (which might not be art or activism), or the cause that matters to them. Both tend to have fewer allergic-type reactions but are more likely to have food sensitivities or chemical sensitivities. Things like wheat sensitivity, soy sensitivity, rashes with the wrong laundry detergent, or headaches after smelling perfume. Both of these personalities thrive on leftovers and fermented foods, even though leftovers and fermented foods are high in histamine.These two personality types also tend to react predictably to supplements, nutrients, and even pharmaceutical drugs. Anything that boosts serotonin, so SSRI medications, St. John's Wort, and melatonin aren't great for these groups. Likewise, the major methyl donors like SAMe, TMG, and DMG are typically not well tolerated by the artist and the activist. Conversely, these groups usually do very well with good sources of folate, like L-5MTHF, food-sourced folate, or folinic acid. Like all people with methylation imbalance, folic acid should not be taken because it can make methylation imbalances worse. Also, the benzodiazepine class of pharmaceuticals is usually well tolerated (although your doctor knows the best choice of pharmaceuticals for you, and your doctor's information is always more informed and correct for you than ours.)Thanks so much for watching today! If you haven't yet discovered your methylation archetype or methylation personality, take the quiz for free now at tohealthwiththat.comAlso, if you're a crappy methylator, MTHFR mutant, or have chronic health issues and you can't figure out why, then check out our online health community. Community.tohealthwiththat.com

Methylation imbalance, often caused by the MTHFR gene mutation, by folic acid excess, or by nutritional deficiencies, shows itself in several personality traits. Some personality traits are common to people with methylation dysfunction, like perfectionism, OCD-tendencies, anxiety, hyper-focus or hypo-focus, and others. These common traits emerge in each methylation archetype pattern in slightly different ways, and by using your personality to determine your methylation archetype, you can benefit by getting general guidelines about supplements and even prescription medications that might work for you.GENETIC ROCKSTARS (an MTHFR community): community.tohealthwiththat.comFREE COURSE: MTHFR Basics: https://to-health-with-that.teachable.com/p/mthfr-basicsWEBSITE: https://tohealthwiththat.com/

She breaks down the considerations for symptom management and potential risks, particularly regarding tumors and blood labs. In this episode of 'To Health With That,' naturopathic doctor Amy Neuzil discusses the complexities surrounding methylfolate dosing for individuals with MTHFR. High doses of methylfolate could come with some of the same risks as high-dose folic acid, so it's essential to find the right dose for you without overdoing it. The three factors to consider are symptom management, potential risks, and serum folate levels. She breaks down the considerations for symptom management, potential risks, particularly regarding tumors, and blood labs. Amy also shares her own methylfolate regime and emphasizes the importance of personalized care and listening to one’s body.00:00 Introduction00:31 Introduction to Folate Toxicity01:25 Considerations for Methylfolate Dosing01:56 Symptom Management02:27 Risks of High Folate Doses02:42 Blood Testing Guidelines03:40 Personal Methylfolate Regime05:34 Importance of Personalized CareThanks so much for for watching or listening. Here are some other links that you might like.The website (and lots of free resources): ⁠https://tohealthwiththat.com⁠Genetic Rockstars - a community for people making the most of their favorite genes and getting better together ⁠https://community.tohealthwiththat.com/⁠FREE MTHFR Basics course: ⁠https://www.tohealthwiththat.com/free-tools⁠

That's right - season 4 of the To Health With That podcast is finished, so let's talk about what you should be doing this summer (having fun), what I should be doing in the fall (writing), and what kind of episodes you can expect. I'd like to call it To Health With That! Season One BONUS Episodes.Thanks so much for being here and adding so much in terms of comments and questions - I couldn't do this without you.In September we'll have occasional episodes about methylation and MTHFR, maximum safe doses of methyl folate, methylation adaptogens, and a few other big topics that come up.Agent? Editor? Just have a comment? Email me! amy @ tohealthwiththat.comIn the season four finale of the 'To Health With That' podcast, host Dr. Amy Neuzil wraps up the season which focused on fatigue - discussing its causes and solutions. She announces a summer break for listeners to enjoy, expressing gratitude for their engagement and inviting them to stay in touch. Amy reveals plans for a reduced schedule next season due to her focus on writing a book, with occasional bonus episodes centered on MTHFR and methylation. Amy also expresses interest in connecting with agents and publishers for her book project and promises updates in the future. The podcast will return with irregular episodes and content mainly focused on MTHFR and methylation topics.00:00 - Intro00:35 - Season Four Wrap-Up and Summer Plans01:09 - A Heartfelt Thank You and How to Stay in Touch01:32 - Looking Ahead: Season One Bonus Episodes and Book Plans02:40 - Signing Off: See You After the Break!GENETIC ROCKSTARS (an MTHFR community): community.tohealthwiththat.comFREE COURSE: MTHFR Basics: ⁠https://www.tohealthwiththat.com/free-tools⁠WEBSITE: https://tohealthwiththat.com/ AFFILIATE LINKS: I appreciate you using these links to purchase products you would buy anyway, because they allow me to keep putting information out there. Thank you!SEEKING HEALTH (metylation and histamine support supplements - these ship internationally): https://bit.ly/3afXYH4STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwt