Huberman Lab

Dr. Arthur Brooks, PhD, professor at Vanderbilt University and senior fellow at Harvard Business School, is an expert on the science of happiness. He shares the three “macronutrients” of true happiness and tools for you to understand what specifically is in the way of you accessing more happiness and a sense of purpose. Dr. Brooks’ work goes beyond stories and observations by offering potent self-discovery tools for you to identify what truly matters most to you and how to shape your life around those things, and doing so, experience more joy and fulfillment. Show notes: https://go.hubermanlab.com/298-arthur-brooks Pre-order Andrew's book Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman Helix Sleep: https://helixsleep.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Arthur Brooks (00:02:40) Public Science Education (00:04:18) Happiness, Unhappiness, Tool: 3 Macronutrients of Happiness (00:07:44) #1: Enjoyment, Pleasure; Animal Impulses vs Moral Aspirations; Exercise (00:17:35) Sponsors: OurPlace & Helix Sleep (00:20:41) Positive Self-Reflection, Public Commitments & Declare Moral Aspiration (00:26:45) Moral Differences, Politics (00:34:02) Tool: Proper Leisure & Values; Enrichment (00:41:47) Deepening Relationships & Shared Suffering (00:48:50) Sponsor: AG1 (00:50:08) #2: Satisfaction, Struggle & Purpose (00:56:32) Struggle & Leisure, High Achievers; Happier with Age, Retirement (01:03:26) #3: Meaning, Regret, Idols (01:10:10) Sponsor: David (01:11:20) Regret, Tool: Identifying Your Idol, Four Idols (01:29:29) Vices & Virtues, Resisting Vices & Pursuing Moral Aspirations (01:35:50) Admiration & Unique Self-Expression; Heroes (01:44:43) Teaching & Sharing Knowledge (01:49:55) Sponsor: LMNT (01:51:15) Idols & Hedonic Treadmill, Addictive Behaviors & Quantification (01:58:26) Life Meaning & Fundamental Experiences, Tool: Break Technology Addiction (02:07:02) Faith, Gradual Exploration, Desire for the Divine (02:12:20) Atheism, Death & Nonexistence; Practice Before Feeling (02:18:18) Practicing Faith, Aging & Deepening Faith; Prayer Practice (02:26:53) Spouse Relationship; Addiction, Workaholism (02:35:06) Meaning of Your Life, Tool: 3 Questions of Meaning (02:43:25) Acknowledgments, Pilgrimages (02:47:23) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Jared Rutter, PhD, Professor of Biochemistry at the University of Utah and Howard Hughes Medical Institute Investigator, is a leading expert on mitochondria and metabolism. He explains how mitochondria produce the energy for your cells to work but also how they regulate cell growth and replication and thereby contribute to health and disease. We also discuss how mitochondria are linked to aging, cancer, and other diseases. Our conversation explores your metabolism as the composite of trillions of individual cells and points to new ways to improve health, avoid, and treat diseases. Show notes: https://go.hubermanlab.com/297-jared-rutter Pre-order Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Jared Rutter (00:02:29) Metabolism, Cells; Aging (00:08:36) Mitochondria, Origin & Cell Complexity (00:13:07) Sponsors: Joovv & BetterHelp (00:15:16) Mitochondria Genome, Inheritance (00:18:18) Mitochondria & Spatial Distribution; Cell-Specific Metabolism (00:25:59) Nutrient Energy, Hormones, Fat Cells (00:31:13) Glucose, ATP Conversion, Pyruvate (00:36:41) Cell Choice: Energy or Growth, Cancer; Virus (00:46:02) Sponsors: AG1 & Eight Sleep (00:48:36) Microbiome, Role of Humans (00:51:44) Molecule Discovery Process, MPC1, MPC2 (00:59:42) Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart (01:07:03) Cell Resource Allocation, MPC, Heart Failure; Disease (01:11:46) Sponsor: Function (01:13:24) Cell Size vs Fuel Balance, Cell Identity & Disease (01:20:43) MPC Discovery, Genetics, Model Systems (01:24:29) Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy (01:31:32) Cancer, Mutations, Metabolism Changes & Warburg Effect (01:36:18) Cancer Challenges & Therapies (01:43:00) Therapy Combinations, Unique Cancer Mutations & Metabolism (01:48:31) Technology to Visualize Metabolism; Disease, Metabolism & Scents (01:56:34) Excess Energy & Mitochondria, Reactive Oxygen Species (02:01:12) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

My guest is Joe Liemandt, technology entrepreneur and principal of Alpha School, a K-12 model that uses AI and individualized learning to help students master academics in just two hours a day, freeing the rest of their time to build businesses, conduct experiments, engage with their communities, and develop practical life skills. We discuss Alpha’s promising results, tools parents and educators can use today, and Joe’s vision for how AI could transform education and human potential. Show notes: https://go.hubermanlab.com/296-joe-liemandt Pre-order Protocols: https://protocolsbook.com Huberman Lab live events: https://www.hubermanlab.com/events Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Lingo: https://hellolingo.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Joe Liemandt (00:03:16) History of Traditional Classroom Model; Education Milestones (00:08:08) Sponsors: David & Lingo (00:10:25) Alpha School, High Standards & Support (00:22:33) Effective Support, Academics vs Athletics; Homeschooling (00:30:03) AI, Individualized Learning & Mastery (00:34:31) Teacher Education, Standardized Tests, Role of School (00:40:52) Sponsors: AG1 & Helix Sleep (00:43:42) AI, Scaffolding Learning, Mastery; Working Memory & Fluency (00:52:41) Working Memory, Focus; Gifted Kids (01:00:30) Basics Mastery, Grade Level Catch-Up, Individualized AI Lessons & Pace (01:06:57) Sponsor: LMNT (01:08:17) Shame, Motivation, Growth Rate; Overcoming Mental Blocks & Paying Kids (01:20:55) Suffering & Motivation, Kids Goals, Sports; Doing Hard Things (01:31:21) Founders High School, Life Skills; Kids' Goals (01:42:44) Reimagining Classroom Education (01:47:21) Importance of Building & Creating, AI & Humanity (01:58:04) Science & Redesigning Experiments, Kids' Interest-Led Projects (02:05:26) Huberman Lab Live Events (02:06:14) Learning Predictors, Gender, Income; Redesigning the School System (02:18:32) Success; Sports Academy, Alpha School Expansion (02:28:36) Acknowledgements (02:31:07) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Masud Husain is a Professor of Neurology & Cognitive Neuroscience at the University of Oxford and a leading expert on the science of motivation, apathy, and neurological diseases. We discuss how dopamine and specific brain circuits shape motivation, including how the brain weighs the trade-off between effort vs reward when deciding what goals to pursue. Dr. Husain also explains practical tools to increase motivation, reduce distractions, and make it easier to start and maintain goal pursuit. We also discuss dementia, Parkinson’s and Alzheimer’s disease, including new insights into cognitive resilience and factors that help protect against age-related cognitive decline. Show notes: https://go.hubermanlab.com/masud-husain-295 Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Masud Husain (00:02:24) Apathy, Motivation (00:08:07) Rewards, Apathy & Motivation; Dopamine (00:13:20) Sponsors: David & BetterHelp (00:15:44) Types of Apathy; Goal Prioritization: Effort vs Rewards (00:23:26) Motivation, Apathy, Tool: Activation Energy & Overthinking (00:29:24) Tools to Increase Motivation: Incentives, Subdivide Tasks, Planning (00:35:13) Subjective Effort, Mental Framing; Learning & Motivation (00:42:24) Sponsors: AG1 & Eight Sleep (00:44:54) Perseverance, Failure; Finding Your Passion, Depression vs Apathy (00:50:58) Self-Concept, Ambition; Life Satisfaction (00:58:25) Psychedelics, Anhedonia & Changing Self (01:03:09) Personal & Social Identity, Tools: Curiosity, Purpose & Dementia Risk (01:11:58) Addiction, Dopamine; Social Media & Dopamine "Hits"? (01:18:36) Sponsor: Function (01:20:13) Dopamine, Parkinson's Disease; Other Roles of Dopamine (01:26:59) Life Purpose, Culture; Reflection, Weighing Decisions (01:34:21) Internal & External Attention (01:39:59) Internal Chatter, Distraction; Working Memory, Stimulants, Nicotine (01:48:54) ADHD, Diagnosis; Attention & Motivation (01:54:34) Goal Planning & Perseverance (01:59:44) Alzheimer's Disease, Dementia, Apathy, Tools: Dementia Risk Factors (02:06:55) Neurodegenerative Disease & Emerging Treatments (02:10:59) Can You Train Attention?, Tool: Reduce Distraction (02:15:14) Enrichment, Art (02:17:45) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Ralph Adolphs, PhD, is a Professor of Psychology, Neuroscience, and Biology at Caltech and a leading expert on the science of human emotions. We discuss how emotions shape our attention and decision-making, whether emotions are truly “stored” in the body, and whether facial expressions are truly reliable signals of emotion. We also cover tools for improving emotional regulation, including cognitive reappraisal and deliberate cold exposure. This episode provides a modern scientific explanation of how emotions are created and regulated in the brain and body, their many impacts on other aspects of brain function, and practical tools for improving emotional wellbeing and processing. Get tickets to Huberman Lab live events: https://www.hubermanlab.com/events Pre-order Andrew's book Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Function: https://functionhealth.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Rorra: https://rorra.com/huberman Timestamps (00:00:00) Ralph Adolphs (00:02:54) Emotions; Qualities of Emotions: Priority, Valence (00:10:00) Qualities of Emotions: Scalability, Persistence (00:15:25) Sponsors: Helix Sleep & Rorra (00:18:17) Do Animals Have Emotions?, Conscious Experience (00:22:58) Monitoring & Regulating Emotions; Emotional Granularity (00:31:22) Emotional Regulation, Tools: Situational Avoidance, Ice Baths (00:37:11) Ultramarathons, Perseverance, Adversity; Awe (00:45:04) Sponsor: AG1 (00:46:17) Perception of Emotions, Amygdala & Fear, Facial Expressions (00:51:59) Interpreting Others' Emotions, Prediction (00:57:52) Emotions as Adaptations to the Environment, Types of Fear (01:00:13) Feeling Emotions in the Body, Pain, Insula (01:08:05) Brain & Body Connection; Marketing & Emotion (01:12:34) Sponsor: Function (01:14:11) Art, Music & Emotion (01:17:43) Interpreting Facial Expressions, Developing Emotions, Flexibility vs Reflexes (01:25:11) Emotional Intelligence, Context-Dependent Social Intelligence; Autism (01:33:31) Sponsor: LMNT (01:34:51) Autism & Social Dynamics, Eye Contact (01:42:01) Change Your Personality?, Body Movement & Thought, Social Interaction (01:47:18) Emotion Regulation, Tool: Training Mental Stillness (01:53:46) Task Switching, Tool: Meditation, Breathing Techniques (02:02:07) Illness, Diagnosis & Emotions, Gratitude & Awe (02:06:52) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Fei-Fei Li, PhD, is a professor of computer science at Stanford University and a pioneer and expert in artificial intelligence (AI). We discuss how AI can be used safely and effectively to extend human capabilities – not just to search for information but specifically to increase human intelligence and creativity. We also discuss how humans collaborating with AI and robots stand to positively transform human health and one’s experience of life. And we cover what makes AI fundamentally different from human cognition, and why your intuition and unique experiences are not replicable by AI or machines. Both AI enthusiasts and skeptics are sure to benefit from the information and tools Dr. Fei-Fei Li shares in this episode. Read the episode show notes at hubermanlab.com. Huberman Lab live events: https://www.hubermanlab.com/events Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Wealthfront*: https://wealthfront.com/huberman Timestamps (00:00:00) Fei-Fei Li (00:03:46) Vision & Intelligence; Human Vision & Contribution to AI (00:12:11) Computer Vision & the AI Revolution (00:18:34) Sponsors: Lingo & Wealthfront (00:21:19) Speech, Sound & AI Development (00:23:36) AI & Contextual Learning, Human Intelligence (00:33:43) Current AI Gaps, Emotion & Creativity (00:45:48) Computers Enhancing Humanity; Tool: Personal Agency & Learning about AI (00:53:04) Sponsors: AG1 & LMNT (00:55:37) Public Discourse about AI (00:57:34) AI to Enhance Scientific Discovery & Healthcare; Human Collaboration (01:07:38) Intuition, Motivation & Human States Beyond AI (01:19:18) Sponsor: David (01:20:37) Social & Ethical Considerations for AI (01:27:38) Kids, Development & AI Tools; Tool: Prompt AI Effectively (01:35:04) Next Frontier for Robotics & AI; Human Agency (01:43:52) Human-Centered AI Future (01:50:10) World Labs, Spatial Intelligence (01:54:12) Concerns about AI & Creativity; Movies, Art, Storytelling (01:59:51) Younger Generation & AI, Teachers (02:05:38) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter *This experience may not be representative of other Wealthfront clients, and there is no guarantee of future performance or success. Experiences will vary. Andrew Huberman receives cash compensation from Wealthfront Brokerage for paid testimonials in his podcast, creating a conflict of interest. The Cash Account, which is not a deposit account, is offered by Wealthfront Brokerage LLC, member FINRA/SIPC. Wealthfront Brokerage is not a bank. The base APY is 3.30% on cash deposits as of January 30, 2026, is representative, subject to change, and requires no minimum. If eligible for the overall boosted rate of 4.05% offered in connection with this promo, your boosted rate is also subject to change if the base rate decreases during the 3 month promo period. Additional terms and conditions apply, which can be found on Wealthfront.com/Huberman. Funds in the Cash Account are swept to program banks, where it earns the variable APY. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer. Investment advisory services are provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, bank-guaranteed or FDIC-insured, and may lose value. Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

My guest is Dr. Matthew (Max) Krummel, PhD, professor at UCSF and one of the world’s leading immunologists. We discuss how your immune system works and how sleep, emotions, and even memories shape immune function. We also explore thymus function, its role in autoimmunity, and its potential role in combating cancer. And we discuss how the type and timing of immunization can impact health. This episode provides an actionable framework for understanding how your immune system works, which ought to benefit people of all ages and health statuses. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Joovv: https://joovv.com/huberman Timestamps (00:00:00) Max Krummel (00:02:18) Immune System, Immunotherapy (00:08:36) Illness, Childhood & Immune System (00:13:02) Aging & Immunity, DNA Mutations (00:18:36) Sponsors: Joovv & Eight Sleep (00:21:14) Self vs Non-Self Recognition, Aging, Cancer; Immune Surveillance (00:30:11) Cancer, Immune System, Age & Measuring Change (00:35:57) Thymus, T Cells; Aging & Cancer (00:42:13) Reproduction, Aging & Immune System; Basic Research (00:47:28) Sleep & Illness Susceptibility (00:52:55) Sponsor: AG1 (00:54:08) Umbilical Cord Banking; Organoids, CAR T Cells, Thymus (01:02:57) Scientific Curiosity, Failures, & Discovery (01:13:14) Spatial Biology & Immune Cells; Memory & Immune State; Stress, Meditation (01:25:00) Sponsor: Function (01:26:37) Mindset; Tissue Engineering, Peptides, Systems Biology (01:34:25) Immunizations in Childhood and Beyond (01:39:37) Pharmaceutical Companies, Public Distrust (01:49:22) Disease Risk, Immunity; Autism, Flu, (01:58:56) Biological Resilience, Cancer; Computational Research (02:08:02) Autoimmune Conditions, Asthma, IBD (02:13:34) Autoimmunity & Genetic Diversity Benefits (02:17:11) Science Communication, Max's Substack (02:24:07) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

I answer questions submitted by listeners about topics ranging from how to ensure great sleep after nighttime exercise, effective no-caffeine pre-workouts (that also improve your sleep quality), neuroscience-supported tools for improving your memory and sense of smell, nutrition and supplementation for improving female and male fertility, the link between (peri)menopause and mental health, accelerating recovery from surgery, how to find your life’s passion, and more. Please note that if your question was not answered this time, we will keep it to consider for future Q&A episodes. A special thank you to everyone who submitted a question! Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman BetterHelp: https://betterhelp.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Your Questions Answered (00:01:42) Late-Day Training & Pre-Workout, Cortisol; Tools: Alpha-GPC, Garlic & TMAO, Hot Shower, Physiological Sigh, Post-Workout Food (00:13:57) Sponsors: Eight Sleep & BetterHelp (00:16:12) Morning Daylight, East vs West Facing, Melanopsin Cells; Tool: Ambient Daylight, Prior Light History (00:22:54) Over-Optimization & Protocol Overwhelm, Core Pillars, Consistency, Resentment, Alcohol (00:33:32) Sponsor: AG1 (00:34:48) Memory, Hippocampus & Neocortex, Exercise & Arousal, Errors, Sleep, Tool: Self-Testing; Sense of Smell, Tool: Sniff Training, Anosmia (00:53:11) Fertility & Nutrition, Body Fat, Testosterone Therapy, HCG & Sperm; Low-Inflammation Diet, Fermented Foods, CoQ10, L-Carnitine (01:08:24) Sponsor: LMNT (01:09:46) Perimenopause & Menopause, Anxiety, Hormone Therapy, Sleep (01:18:08) Sunrise vs Sunset Wedding, Chronotypes (01:22:52) Kidney Donation & Surgery Recovery; Tools: Prehabilitation, Circadian Rhythm in the Hospital; Muscle Memory (01:30:57) Careers in Science (01:32:05) Finding Your Passion, Structure & Work, “No Input, No Output”; Tool: Chop Wood, Carry Water (01:43:49) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices