Huberman Lab

Ross Edgley is a British ultra-endurance athlete and author known for completing extraordinary athletic feats by tapping into diverse sources of motivation and resilience. We discuss the psychological and biological forces that allow people to persevere through extreme challenges. Then we cover how to dynamically update your sense of purpose, emotions, philosophy, and personal narratives to expand your ability to overcome adversity of all kinds. We also discuss the brain circuits and science of fatigue and stress adaptation. Ultimately, a new framework emerges that you can use to access persistent motivation. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (00:00:00) Ross Edgley (00:03:19) Childhood, Motivation Sources; Competition, Pain & Purpose (00:11:51) Anterior Midcingulate Cortex, Wheel of Motivation & Tenacity (00:16:05) Honoring Your Commitment, Ultra-Endurance Swimming, Self-Respect (00:17:46) Sponsors: David & Lingo (00:20:02) Fear of Shame, Iceland; Team Events, Injuries & Sea Swims (00:25:50) Spiritual Experiences, Loch Ness, Iceland, Mythology & Motivation (00:31:37) Dorsolateral Prefrontal Cortex, Persistence & Winning, Strategy (00:36:27) Energy Management; Leadership & Team (00:40:56) Addiction, Evaluating Challenges & Purpose, Support & Yukon (00:47:23) Fear & Animals, Great White Sharks, Bears (00:53:09) Sponsor: AG1 (00:54:22) Proving Others Wrong, Anger, Great Britain Swim (00:57:55) Anger at Self; Doing It For the Sake of Others, Son, Father (01:08:58) Next Endeavor, Money, Helping Others (01:15:29) Dark vs Light Energy, Self-Discipline; Yaminawa Tribe (01:22:51) Sponsor: LMNT (01:24:11) Challenge Stakes, Ultra-Endurance Swims; Negative Thoughts (01:33:29) Tongue; Iceland Swim, Berserker, Third-Person Perspective (01:38:28) Pain Tolerance, Stress Inoculation, Deliberate Cold Exposure (01:45:48) Strength Training (01:48:10) Sponsor: Eight Sleep (01:49:38) Process vs Outcomes, Psychological Adaptability (01:55:07) Cyclops & Tunnel Vision, Yukon Swim; Cuttlefish (02:02:02) Caffeine, Nicotine, Alpha GPC, Creatine, Supplement Use (02:11:59) Strength Training & Workouts, Strength Reserve, Endurance (02:20:26) Girlfriend, Worry; Doing What Others Cannot, Gratitude (02:29:13) Absurd Hero, Pleasure in Struggle (02:31:14) Smile, Motivated through Anger; Spirit Animals (02:41:37) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Jared Diamond, PhD, is a Pulitzer Prize-winning author, physiologist, evolutionary biologist and Professor at UCLA. We discuss the surprising and often chance events that shaped human history and leadership in politics, religion, business and athletics. As one of the most influential public-facing scholars of the last 100 years, Dr. Diamond also shares his advice on how to pursue a career and life that reflects your unique interests and that makes a positive contribution to the world. He also shares the tools he uses to keep his mind and body vigorous. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Rorra: https://rorra.com/huberman Timestamps (00:00:00) Jared Diamond (00:02:51) Leadership, Prophets; Hitler, WWII (00:09:17) Hitler, Leadership, Deception (00:11:45) Unlikely Leader: Harry Truman (00:13:45) Sponsors: Rorra & Eight Sleep (00:16:28) Leaders, Introspection, Charisma; Individuals, History Patterns (00:22:35) Leaders & Addressing Mistakes, Forgiveness (00:25:36) Religious Leaders, Jesus & Leadership, Organizers (00:30:42) Leader Partnerships, Science, Religion (00:35:18) Jim Jones, Effective Cult Leaders; Followers (00:39:53) Sponsor: AG1 (00:41:06) Leaders & Clinging to Power (00:44:29) Learning Languages (00:49:59) Taxonomy, Lists & Names, Studying Birds (00:56:41) Curiosity, New Guinea Birds, Success & Support Across Different Careers (01:04:55) Travel, Intellectual Explorer (01:07:44) Birds, Vision & Sound, Ecology; Bird Song, Monkeys (01:14:50) Sponsor: Function (01:16:27) Academic Leadership; Time & His Remaining Projects (01:25:54) Humanity Risks, Population Bomb (01:30:46) Physical Activity; Sports Leaders (01:38:08) Coaching Philosophy, John Wooden; Business Leaders, Yvon Chouinard (01:44:31) Great Leadership; Advice for Others (01:51:22) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Scott Kanoski, PhD, is a Professor of Human and Evolutionary Biology and Neurobiology at the University of Southern California. We discuss how different foods impact memory and cognitive function as well as cravings. We also discuss how GLP-1 drugs work to control hunger in the brain and body, the role of the gut microbiome, and the effects of artificial and low calorie sweeteners on hunger and satiety. This episode highlights how nutrition impacts much brain health and learning capacity and how our memory impacts food choices too. Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Function: https://functionhealth.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Our Place: https://fromourplace.com/huberman Timestamps (00:00:00) Scott Kanoski (00:02:33) GLP-1, Natural GLP-1 Production; GLP-1 Drugs, Microdosing (00:07:06) GLP-1 Drugs & Benefits (00:10:36) Sponsor: Our Place & Helix Sleep (00:13:24) GLP-1 & Hunger Suppression, Vagus Nerve; Food Noise (00:18:39) Artificial Sweeteners & Appetite, Preclinical Studies (00:26:50) Memory & Meals; Stress; Eating & Individualization, Fasting (00:33:42) Memory Impairments, Western Diet, High Sugar, Processed Food (00:42:33) Sponsor: AG1 (00:43:46) Dementia, Alzheimer’s Disease & Western Diet; Exercise (00:49:40) Vagus Nerve, Hippocampus & Memory, Hormones (00:57:10) Sugar & Fat Consumption, Memory; Engineering Food for Quality (01:04:32) GLP-1s, Nutrient Deficiency, Weight Loss & Other Effects (01:11:33) Sponsor: LMNT (01:12:54) Vagus Nerve & Hippocampus, Eating & Acetylcholine (01:21:05) Hippocampus, Memory & Food; Interoceptive Awareness & Western Diet (01:27:21) Omega-3s; Microbiome & Processed Foods (01:34:00) Microbiome, Antibiotics, C. diff Infection (01:37:23) Sponsor: Function (01:39:01) Foods to Enhance Microbiome; Rising Obesity & Highly Processed Food (01:43:39) Dopamine & Food Choice, Change Food Cravings (01:49:50) Food Addiction, Highly Processed Foods; Political Lobbying (01:56:43) Oxytocin, Reduced Food Consumption, Social Eating (02:00:11) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Social Media, Neural Network Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Beth Shapiro, PhD, is an evolutionary biologist and Chief Science Officer at Colossal Biosciences. Her work focuses on de-extinction and wildlife conservation efforts. We discuss genetic differences among humans, and how ancient DNA and modern embryology are being used to de-extinct and protect woolly mammoths, dodo birds, and dire wolves, as well as to help conserve endangered species. We also explore the ethical implications of de-extinction and how synthetic biology can help build a more bio diverse and resilient world. Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Beth Shapiro (00:02:35) What is a Species?, Taxonomy, Bison (00:09:13) Neanderthals, Denisovans, Homo Sapiens (00:12:38) Sponsors: Joovv & Eight Sleep (00:15:27) Hybrid Ancestry, “Grolar” Bears (00:20:30) Homo Sapiens & Neanderthal Interbreeding, Genes; Denisovans (00:25:53) Neanderthal Genes, Immunity, Red Hair; Eye Color (00:30:17) De-Extinction, Species Selection, Woolly Mammoths (00:38:08) Sponsor: AG1 (00:39:21) Bird De-Extinction, Dodo; Reproduction & Genes (00:47:40) Development Biology, Woolly Mammoth, Elephants (00:54:49) Dire Wolf, Synthetic Biology, Ethics (01:03:26) De-Extinction, Ecology, Conservation, Ethics (01:09:22) Ecosystem Resilience, Thylacine; Preventing Extinction, Quolls (01:15:45) Sponsor: Function (01:17:23) Modeling Ecological Impact, Mosquitoes, Gene Drives; Panthers (01:25:50) Advisory Panels, Synthetic Biology Education (01:29:13) Genetic Selection in Humans, Human-Shaped World (01:38:25) Black-Footed Ferrets, Genetic Rescue (01:47:05) Dire Wolf; Ecological Modeling, New Technology & Public Fear (01:55:09) Artificial Wombs; Current Issues, Conservation & Red Wolf (02:01:26) Science Pioneers; Colossal Public Education (02:04:31) Beth’s Science Origin Story; Dinosaurs (02:13:42) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Michael Pollan is a renowned author, journalist and professor at UC Berkeley. He is best known for his influential works on how humans and plants have shaped each other at the level of food, medicine, health, and culture. In this episode we discuss consciousness—what it is and how the recognition between our self vs others contributes to-- but also can impair, certain aspects of conscious experience. We discuss psychedelics, the microbiome, caffeine, and how the unconscious dialogue between our body and brain impacts our thoughts and feelings. Pollan offers a hopeful perspective on how our relationship with plants and animals – including other humans, can lead us to a healthier, and far richer experience of life. Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Mateina: https://drinkmateina.com Rorra: https://rorra.com/huberman Timestamps (00:00:00) Michael Pollan (00:02:50) Wendell Berry, Nature (00:06:30) Consciousness; Sentience (00:10:04) Environmental Response, Plant Intelligence; Self-Recognition (00:13:52) Sponsors: Eight Sleep & Rorra (00:20:49) Plants, Communication, Sentience, Symbiosis (00:27:37) Self-Awareness, Time; Xenobots, Instinct (00:34:32) Microbiome, Influence & Symbiosis (00:40:28) Meaning; Cortex vs Brain Stem, Homeostatic Feelings (00:47:17) Sponsor: AG1 (00:48:36) Body & Brain Communication, Vagus Nerve (00:57:21) Collective Consciousness, Psychedelics, Ego, Awe (01:08:14) Filter Theories of Consciousness (01:13:28) Sponsor: Function (01:15:06) AI, Consciousness, Feelings; Memory; Quantum Effects (01:21:27) Childhood, Gardening, Interacting with Nature (01:27:08) Hope, Nature & Agency, Food Industry (01:32:21) Advocacy, Psychedelics, Food Industry (01:39:50) Sponsor: Mateina (01:44:52) Psychedelics, Ibogaine, Veterans, Politics; MDMA, Psilocybin; Risk (01:52:18) Caffeine, Caffeine Fast, Health Benefits (02:00:21) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Chris Thompson, MD, Professor of Medicine at Harvard Medical School, Chief of Interventional Gastroenterology at Mass General Brigham in Boston, and Co-Director of the Center for Weight Management and Wellness, is a world-renowned expert on gastroenterology, metabolism, nutrition, and obesity medicine. He explains how your GI tract regulates hunger, fullness, and blood sugar, as well as the gut microbiome, metabolic health, and weight loss. We also discuss common GI tract issues and which particular tests or interventions are actually useful. We discuss both GLP-1 medications and non-GLP-1 approaches to weight loss. Given that gut health is vital to all the organs of the body, overall health, and longevity, our discussion ought to be of interest and practical value to everyone, including, of course, those struggling with gut health or weight loss challenges. Thank you to our sponsors AG1: https://drinkag1.com/huberman Function: https://functionhealth.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Our Place: https://fromourplace.com/huberman Timestamps (00:00:00) Dr. Chris Thompson (00:02:16) Digestive Tract, Gut Hormones & Nutrient Absorption (00:08:06) Colon Microbiome & Colon Cancer Screening (00:11:13) Sponsors: LMNT & Lingo (00:13:40) Swallowing Problems & Zenker's Diverticula (00:16:08) Bowel Movements & Constipation (00:18:28) Fiber, Resistant Starch & the Gut Barrier (00:21:50) Intermittent Fasting & the Gut Microbiome (00:23:38) Fermented Foods, Microbial Diversity & Butyrate (00:27:12) H. pylori, Stress & Stomach Ulcers (00:30:20) GLP-1 Medications: Benefits & Limitations (00:33:42) Lower GLP-1 Doses, Weight Regain & Muscle Loss (00:37:35) GLP-1 Side Effects, Food Noise & Apathy (00:39:49) Bariatric Surgery & Medical Innovation (00:46:07) Sponsor: AG1 (00:47:44) Hunger & Satiety: Ghrelin, CCK, GIP & GLP-1 (00:50:01) Retatrutide & Combining Hormonal Targets (00:52:55) Ultra-Processed Foods, Overeating & Leptin (00:55:32) Incretin Discovery, Exendin-4 & the Gila Monster (00:59:35) Endoscopic Ultrasound & Pancreatic Biopsy (01:07:40) Early Metabolic Markers, CGMs & Fasting Insulin (01:13:06) Insulin Resistance & Metabolic Flexibility (01:15:53) Sponsor: Function (01:17:35) Patient Data, Screening & Treatment Adoption (01:26:31) AI, Robotics & Improving Procedures (01:29:27) Choosing a Surgeon & Measuring Procedure Quality (01:35:29) Image Guidance & Hyperspectral Imaging (01:37:19) Sponsor: Our Place (01:38:56) Diagnostics & Targeted Metabolic Treatments (01:42:45) Gastric Bypass, Foregut Exclusion & Diabetes (01:47:59) Duodenal Liners & Mucosal Resurfacing Research (01:52:58) Gut Permeability, Inflammation & Fatty Liver (01:59:39) Artificial Sweeteners, Fructose, Fats & Omega-3s (02:05:00) Resistance Training, Zone 2 Cardio & Intervals (02:06:31) Weight Set Point & Metabolic Adaptation (02:08:13) Endoscopic Sleeve Gastroplasty & Fundus Ablation (02:10:30) Magnetic Intestinal Connections & Combined Treatments (02:16:52) GLP-1 Gene Therapy Research (02:22:13) Innovation, Problem Solving & Teamwork (02:25:58) Zero-Cost Support, Sponsors & Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Arthur Brooks, PhD, professor at Vanderbilt University and senior fellow at Harvard Business School, is an expert on the science of happiness. He shares the three “macronutrients” of true happiness and tools for you to understand what specifically is in the way of you accessing more happiness and a sense of purpose. Dr. Brooks’ work goes beyond stories and observations by offering potent self-discovery tools for you to identify what truly matters most to you and how to shape your life around those things, and doing so, experience more joy and fulfillment. Show notes: https://go.hubermanlab.com/298-arthur-brooks Pre-order Andrew's book Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman Helix Sleep: https://helixsleep.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Arthur Brooks (00:02:40) Public Science Education (00:04:18) Happiness, Unhappiness, Tool: 3 Macronutrients of Happiness (00:07:44) #1: Enjoyment, Pleasure; Animal Impulses vs Moral Aspirations; Exercise (00:17:35) Sponsors: OurPlace & Helix Sleep (00:20:41) Positive Self-Reflection, Public Commitments & Declare Moral Aspiration (00:26:45) Moral Differences, Politics (00:34:02) Tool: Proper Leisure & Values; Enrichment (00:41:47) Deepening Relationships & Shared Suffering (00:48:50) Sponsor: AG1 (00:50:08) #2: Satisfaction, Struggle & Purpose (00:56:32) Struggle & Leisure, High Achievers; Happier with Age, Retirement (01:03:26) #3: Meaning, Regret, Idols (01:10:10) Sponsor: David (01:11:20) Regret, Tool: Identifying Your Idol, Four Idols (01:29:29) Vices & Virtues, Resisting Vices & Pursuing Moral Aspirations (01:35:50) Admiration & Unique Self-Expression; Heroes (01:44:43) Teaching & Sharing Knowledge (01:49:55) Sponsor: LMNT (01:51:15) Idols & Hedonic Treadmill, Addictive Behaviors & Quantification (01:58:26) Life Meaning & Fundamental Experiences, Tool: Break Technology Addiction (02:07:02) Faith, Gradual Exploration, Desire for the Divine (02:12:20) Atheism, Death & Nonexistence; Practice Before Feeling (02:18:18) Practicing Faith, Aging & Deepening Faith; Prayer Practice (02:26:53) Spouse Relationship; Addiction, Workaholism (02:35:06) Meaning of Your Life, Tool: 3 Questions of Meaning (02:43:25) Acknowledgments, Pilgrimages (02:47:23) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

My guest is Dr. Matthew (Max) Krummel, PhD, professor at UCSF and one of the world’s leading immunologists. We discuss how your immune system works and how sleep, emotions, and even memories shape immune function. We also explore thymus function, its role in autoimmunity, and its potential role in combating cancer. And we discuss how the type and timing of immunization can impact health. This episode provides an actionable framework for understanding how your immune system works, which ought to benefit people of all ages and health statuses. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Joovv: https://joovv.com/huberman Timestamps (00:00:00) Max Krummel (00:02:18) Immune System, Immunotherapy (00:08:36) Illness, Childhood & Immune System (00:13:02) Aging & Immunity, DNA Mutations (00:18:36) Sponsors: Joovv & Eight Sleep (00:21:14) Self vs Non-Self Recognition, Aging, Cancer; Immune Surveillance (00:30:11) Cancer, Immune System, Age & Measuring Change (00:35:57) Thymus, T Cells; Aging & Cancer (00:42:13) Reproduction, Aging & Immune System; Basic Research (00:47:28) Sleep & Illness Susceptibility (00:52:55) Sponsor: AG1 (00:54:08) Umbilical Cord Banking; Organoids, CAR T Cells, Thymus (01:02:57) Scientific Curiosity, Failures, & Discovery (01:13:14) Spatial Biology & Immune Cells; Memory & Immune State; Stress, Meditation (01:25:00) Sponsor: Function (01:26:37) Mindset; Tissue Engineering, Peptides, Systems Biology (01:34:25) Immunizations in Childhood and Beyond (01:39:37) Pharmaceutical Companies, Public Distrust (01:49:22) Disease Risk, Immunity; Autism, Flu, (01:58:56) Biological Resilience, Cancer; Computational Research (02:08:02) Autoimmune Conditions, Asthma, IBD (02:13:34) Autoimmunity & Genetic Diversity Benefits (02:17:11) Science Communication, Max's Substack (02:24:07) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices