Health Optimization Medicine Podcast

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz reunite in person in Washington, D.C.. Moving away from traditional classifications of illness, the team breaks down a powerful paradigm shift: chronic disease and aging are not separate processes—chronic disease is aging. Drawing from the pioneering frameworks of biogerontologist Aubrey de Grey and the SENS Research Foundation, they discuss how flawed metabolism inherently accumulates structural damage long before a clinical diagnosis ever appears. Join us as we delve into: •The Metabolism Flaw: How the very process keeping us alive produces reactive oxygen species and damage that eventually leads to tissue breakdown and pathology. •Reclassifying Disease: Moving past the old congenital vs. infectious vs. chronic model to target metabolism directly. •The $30,000 Stem Cell Mistake: Why dropping thousands on mesenchymal stem cells (MSCs) or exosomes is a waste of money if your body is trapped in a cellular defense posture. •The Cell Danger Response (CDR): Understanding Robert Naviaux's work on how ancient defense mechanisms shut down growth and repair under stress. •Morbidity Compression: Shifting your biology back to your optimal 21-to-30-year-old baseline to maximize healthspan and ensure you live vibrant before a rapid, peaceful end. This episode is for you if: •You want to understand why biohacking shortcuts like stem cells require metabolic priming to actually work. •You are tired of "normal" lab ranges meant for a sick population and want true, age-optimized biomarkers. •You want to stop guessing what vitamins or antioxidants your body needs and start measuring your exact metabolomic fingerprint. You can also find this episode on… YouTube: https://youtu.be/DygsezbmZxM Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty (Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers) dive deep into the unseen world inside your stomach. Moving beyond simple probiotics, they discuss the gut as a "post-natal organ" and explore how the trillions of microbes inside you actually dictate your cravings, your mood, and your immune system. 𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘀 𝘄𝗲 𝗱𝗲𝗹𝘃𝗲 𝗶𝗻𝘁𝗼: •The "tripartite axis" (Gut-Brain-Enteric Microbiota) and how it links directly to treatment-resistant depression and anxiety. •Why the vagus nerve is the master switch for your rest-and-digest parasympathetic nervous system. •The concept of the "Holobiont": Why your microbial DNA is 100 times larger than your human DNA. •How a single weekend of bad eating or a disrupted sleep schedule can completely derail your microbiome in just 72 hours. •Why vegetarians sometimes struggle with massive bloating and methane gas production due to bacterial overgrowth. 𝗧𝗵𝗶𝘀 𝗲𝗽𝗶𝘀𝗼𝗱𝗲 𝗶𝘀 𝗳𝗼𝗿 𝘆𝗼𝘂 𝗶𝗳: •You struggle with brain fog, anxiety, or treatment-resistant mood changes. •You want to understand the actual mechanics behind "gut feelings" and sudden sugar cravings. •You are tired of standard GI advice and want to learn how clinical metabolomics maps your microbiome. •You want actionable steps to rebuild your gut ecosystem over the next 3 to 6 months. 𝗬𝗼𝘂 𝗰𝗮𝗻 𝗮𝗹𝘀𝗼 𝗳𝗶𝗻𝗱 𝘁𝗵𝗶𝘀 𝗲𝗽𝗶𝘀𝗼𝗱𝗲 𝗼𝗻… YouTube: https://youtu.be/2zhBdAHwuEU 𝗙𝗶𝗻𝗱 𝗺𝗼𝗿𝗲 𝗳𝗿𝗼𝗺 𝗛𝗲𝗮𝗹𝘁𝗵 𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗠𝗲𝗱𝗶𝗰𝗶𝗻𝗲 𝗮𝗻𝗱 𝗣𝗿𝗮𝗰𝘁𝗶𝗰𝗲 (𝗛𝗢𝗠𝗲𝗛𝗢𝗣𝗲): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics 𝗙𝗶𝗻𝗱 𝗺𝗼𝗿𝗲 𝗳𝗿𝗼𝗺 𝗧𝗿𝗼𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻𝘀: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty comes together for a roundtable conversation exploring the science and clinical application of creatine. Moving beyond its reputation as just a performance supplement for "gym bros," Boomer Anderson, Dr. Scott Sherr, Dr. Allen Bookatz, and Dr. Ted Achacoso break down how creatine functions as a critical cellular battery buffer. Join us as we delve into: How creatine bypasses the "methylation tax" by saving the body from depleting SAMe reserves to produce energy. Why muscle is a metabolic determinant of resilience and not just a cosmetic feature. The evolutionary mismatch that increases our cellular energy demands due to a highly sympathetic, stressed lifestyle. The role of creatine in brain health is particularly important for supporting working memory, mitigating cognitive fatigue, and protecting against excitotoxicity. This episode is for you if: You are curious about how to support your body's cellular energy and mitochondrial function. You follow a vegetarian or plant-based diet and want to understand your specific creatine supplementation needs. You want to understand the difference between maintaining muscle for aesthetic reasons versus metabolic health. You are looking for strategies to mitigate mental fatigue and sleep deprivation. You can also find this episode on... YouTube: https://youtu.be/R4x9tu56FXg Find more from Health Optimization Medicine and Practice (HOMeHOPe):Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions:Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

In this episode of the Smarter Not Harder Podcast, Dr. Linda Kiley joins Dr. Scott Sherr for a groundbreaking conversation on functional urogynecology — exploring the real causes of pelvic and bladder pain that most conventional models miss. Dr. Kiley shares how she uses muscle exams, peptide protocols, and root-cause diagnostics to treat conditions like interstitial cystitis, chronic UTIs, pelvic floor dysfunction, and endometriosis — often without surgery or long-term antibiotics. If you or someone you love has been told "there's nothing wrong" but still struggles with pelvic discomfort, bladder issues, or sexual pain, this episode is a must-listen. Join us as we explore: • The pelvic floor as a dynamic system — not just "tight or weak" • Biofilms, interstitial cystitis, and smart testing for chronic infections • How gut health and systemic inflammation drive pelvic pain • Natural, non-invasive approaches to bladder and pelvic restoration This episode is for you if: • You experience chronic UTIs, bladder discomfort, or pelvic pain • You've been dismissed or misdiagnosed by conventional providers • You're a clinician seeking better diagnostics for pelvic dysfunction • You want to understand how muscle tone, breathing, and biofilms intersect You can also find this episode on… YouTube: https://youtu.be/JLZ5iIBFkls?si=yaoHg-qrxF2XCx1n Find more from Dr. Linda Kiley: Website: https://drlindakiley.com/ Instagram: https://www.instagram.com/drkileyurogyn/ YouTube: https://www.youtube.com/@theholisticurogynecologist3891 LinkedIn: https://www.linkedin.com/in/linda-kiley-5999462b/ More from Smarter Not Harder: Website: Smarter Not Harder podcast Instagram: https://instagram.com/troscriptions/ HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Get 10% off your purchase of the Clinical Metabolomics module with code PODCAST10 at https://www.homehope.org/ Get 10% off your Troscriptions purchase with code POD10 at https://www.troscriptions.com/ Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, Dr. Amanda Wiggins joins Jodi Duval to explore one of the most promising frontiers in longevity and neuroscience: brain vascular health. From her discovery of CGP (cyclic glycine-proline) to the science behind neurovascular aging, Dr. Wiggins explains why capillaries, inflammation, and even insulin play a much bigger role in dementia than most people realize. From biotech insights to personal stories, this conversation reveals what we can all do — starting now — to protect our brains as we age. Join us as we explore: • What CGP is and how it supports the blood-brain barrier • How brain vascular health is central to dementia prevention • Why IGF-1, capillaries, and inflammation matter more than we thought • How to start optimizing brain health — simply and effectively This episode is for you if: • You want to understand the vascular root of cognitive decline • You're looking for emerging therapies to support brain health • You're navigating aging, menopause, or brain fog • You believe that prevention is smarter than hard treatment You can also find this episode on… YouTube: https://youtu.be/xx8L00x7PGI Learn more about Dr. Amanda Wiggins:Website: https://cgpmax.com/ LinkedIn: https://www.linkedin.com/in/amandawiggins/ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast Instagram: https://www.instagram.com/troscriptions/ HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Get 10% Off your purchase of the Clinical Metabolomics module with code PODCAST10 at Let's bring Health HOMe - HOMeHOPe Get 10% Off your Troscriptions purchase with code POD10 at Troscriptions® - Buccal Troches for Health Optimization Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, Dr. Libby Weaver joins Jodi Duval for an illuminating conversation about iron — the most overlooked yet essential nutrient for mood, cognition, metabolism, and long-term health. Together, they break down myths, lab test pitfalls, supplement confusion, and why so many women and children remain iron-deficient despite "normal" results. From hepcidin and hormone shifts to sport, anxiety, and pregnancy, this is the deep dive into iron you didn't know you needed. Join us as we explore: • What hepcidin is and why it's the key to iron absorption • Why teenage girls and high-performing women are so often iron-deficient • Iron infusions: when they're needed — and when they're not • Testing errors, supplement types, and food-based solutions This episode is for you if: • You've ever been told your iron is "normal" but still feel exhausted • You've had recurring iron infusions or failed supplements • You're a practitioner wanting clarity on dosing, testing, and absorption • You want to support kids, teens, and athletes with better iron strategies You can also find this episode on…Youtube: https://youtu.be/chuWc53iw2g Find more from Dr. Libby Weaver: Website: https://www.drlibby.com Instagram: https://www.instagram.com/DrLibby/ Facebook: https://www.facebook.com/DrLibbyLive YouTube: https://www.youtube.com/@drlibby6300 LinkedIn: https://www.linkedin.com/in/dr-libby-phd-3a497531/ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast?utm_source=youtube&utm_medium=video&utm_campaign=snh_podcast_guest_episode_2025_10&utm_content=podcast_asset Instagram: https://www.instagram.com/troscriptions HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Get 10% Off your purchase of the Clinical Metabolomics module with code PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase with code POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, Dr. Matthew Bernstein joins Jodi Duval for a pioneering conversation about the rise of metabolic psychiatry — the intersection of mitochondrial health, nutrition, and brain performance. From ketogenic therapy to personalized mental health biomarkers, this episode offers a radically hopeful perspective on treating conditions like depression, OCD, bipolar disorder, and schizophrenia. Join us as we explore: • What metabolic psychiatry is and why it matters now • How insulin resistance, inflammation, and mitochondria affect mood and cognition • Why ketones aren't just fuel — but also powerful brain signals • Tools like CGMs, RCTs, and the ACCORD program • Supplements and real-world protocols for psychiatric healing This episode is for you if: • You or someone you love has struggled with medication-resistant mental illness • You're curious how nutrition and metabolism affect the brain • You want a psychiatrist's view on keto, CGMs, and continuous feedback • You believe mental health deserves smarter, not harder solutions You can also find this episode on… YouTube: https://youtu.be/-B6A63IG9p4 Find more from Dr. Matthew Bernstein: Accord Program: https://accordmh.com/ LinkedIn: https://www.linkedin.com/in/mattbernsteinmd/ Instagram: https://www.instagram.com/accordmh/ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast?utm_source=youtube&utm_medium=video&utm_campaign=snh_podcast_guest_episode_2025_10&utm_content=podcast_asset Instagram: https://www.instagram.com/troscriptions Get 10% Off your purchase of the Clinical Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase with code POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Smarter Not Harder Podcast, Cynthia Thurlow joins Dr. Scott Sherr for a wide-ranging and refreshingly honest conversation about fasting, female hormones, GLP-1s, and navigating midlife as a high-performing woman. With clarity and nuance, Cynthia breaks down what works — and what backfires — when it comes to metabolic health for women over 35. Join us as we delve into: • Why intermittent fasting isn't a one-size-fits-all solution • How hormone shifts change the fasting game for women • What GLP-1s like Ozempic and Wegovy really do — and don't do • How to stay metabolically flexible through perimenopause This episode is for you if: • You're a woman over 35 trying to fast smarter, not harder • You're curious about GLP-1s but want balanced, science-based insight • You've hit a metabolic wall and need smarter strategies • You want practical, hormone-informed tools for fat loss and focus You can also find this episode on… YouTube: https://youtu.be/5oVPHVbyUcw Find more from Cynthia Thurlow: Website: https://www.cynthiathurlow.com Instagram: https://www.instagram.com/cynthia_thurlow_ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast?utm_source=youtube&utm_medium=video&utm_campaign=snh_podcast_guest_episode_2025_10&utm_content=podcast_asset Instagram: https://www.instagram.com/troscriptions Get 10% Off your purchase of Clinical Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.