High Performance Longevity

Your annual physical came back "normal," so why do you still feel foggy, tired, and stuck? Dr. Adrijana Kekic says your biology has probably been drifting for years before any standard test notices. Former Mayo Clinic pharmacogenomics specialist and Futurome founder Dr. Adrijana Kekic reveals what a standard 30 to 100 marker panel misses, how multi-omics testing catches metabolic drift early, and why women age differently after 40. After a preventable pulmonary embolism nearly killed her, she rebuilt her own health and now maps cellular aging for people who look fine on paper. Meet our guest Dr. Adrijana Kekic is a pharmacist and nutritionist trained in genetics, one of the first pharmacogenomics clinical specialists at Mayo Clinic and winner of its 2023 Innovation Award. She founded Futurome, a precision health intelligence company that reads thousands of biomarkers to map cellular aging, with a special focus on female biology. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Standard panels lean on late markers; fasting insulin and HOMA-IR flag metabolic trouble years earlier. Multi-omics testing reads thousands of markers across genomics, proteomics, metabolomics, and microbiome. Cellular aging spikes around 40 and 60, the windows where personalization pays off most. The highest mitochondrial density in women sits in the ovaries; decline can surface there before any blood test. Perimenopause is estrogen swinging up and down, not just falling; it hides on standard labs. Women make about 50% less gut serotonin than men, so fasting protocols should differ by sex. Foundation first: sleep, magnesium, vitamin D, movement, and a CGM before advanced interventions. Episode highlights 0:00 Normal labs, hidden aging 6:09 What standard bloodwork misses 18:24 The two aging cliffs at 40 & 60 25:33 The perimenopause you don't notice 30:27 The ICU wake-up call 40:40 Foundation before shiny objects 46:18 Why men & women differ Links Watch it on YouTube: https://youtu.be/1P-vuKmzvtw Full episode show notes: https://outliyr.com/275 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Why does the average dog now live 7 fewer years than one did in the 1970s? Holistic veterinarian Dr. Judy Morgan says the answer is sitting in the food bowl, and it's fixable. With 36 years in practice and a base in traditional Chinese veterinary medicine, Dr. Judy Morgan explains how food became the foundation of her work, why dry kibble fails dogs and cats, and the simple whole foods that add years of healthy life. This is a rare episode on how pet health and human health mirror each other. Meet our guest Dr. Judy Morgan (DVM, CVA, CVCP, CVFT) is an integrative veterinarian, acupuncturist, chiropractor, food therapist, and best-selling author with more than 40 years in animal health. Named IAOTP Holistic Veterinarian of the Decade for 2024, she runs Dr. Judy Morgan's Naturally Healthy Pets, helping pet parents worldwide heal with food and natural therapies instead of defaulting to chemicals and processed food. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways The average medium-sized dog's lifespan fell from 17 years to about 10, which Dr. Morgan considers reversible. Dry kibble is capped near 30% meat and can be 50 to 60% carbohydrates, which pets do not require. Roughly 40% of pet-food ingredients are upcycled byproducts, and unnamed "meat meal" can be any species. Pets test 10 to 25 times higher than their owners for cancer-linked household chemicals. Low phosphorus and high moisture matter far more than restricting protein in kidney disease. Cheap whole-food toppers like sardines, eggs, blueberries, and pumpkin make a real difference. Delaying spay or neuter protects joints, hormones, and longevity in large breeds. Episode highlights 00:00 The dog healed by food, and the owners who lost 200 pounds06:37 Why moisture matters more than the bag admits26:53 What really goes into "meat meal"32:29 Pets need zero carbohydrates42:12 Lifespan 17 to 10, and why it's reversible44:45 The cheap whole foods to add today59:04 The spay and neuter timing rethink Links Watch it on YouTube: https://youtu.be/mU0sdbXCj3s Full episode show notes: https://outliyr.com/273 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

What if your brain fog, anxiety, and memory lapses all trace back to one thing: an inflamed brain? Naturopathic physician Dr. Jaquel Patterson, ND, MBA joins Nick Urban to explain neuroinflammation in plain language and map the root causes behind it. With 16 years of clinical experience in Lyme disease, autoimmune conditions, and integrative psychiatry, she connects the gut, hormones, chronic infections, and environmental toxins to the same inflammatory loop, and lays out how to calm it naturally. Meet our guest Dr. Jaquel Patterson is an internationally recognized naturopathic physician, three-time Amazon bestselling author, and founder and CEO of Fairfield Family Health, a multidisciplinary practice in Connecticut with 9 doctors offering telemedicine nationwide. She has a TEDx talk on root-cause medicine coming soon. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Neuroinflammation shows up as brain fog, poor focus, memory lapses, and mood swings, an inflamed brain "on fire" The blood-brain barrier keeps out about 98% of solutes until chronic inflammation breaks it down About 90% of your serotonin is made in the gut, linking gut health directly to mood and cognition Deep sleep runs the brain's lymphatic clean-out, and sauna lowers CRP and IL-6 A standard CBC can miss iron deficiency for 3 to 6 months Curcumin downregulates IL-6, and phosphatidylserine lowers cortisol while sharpening focus Small, consistent micro-moments beat dramatic overhauls that never stick Episode highlights 01:09 The "brain on fire" explanation 02:30 Microglia as your brain's garbage men 11:51 Leaky gut, leaky brain 17:13 Sleep and sauna to lower inflammation 27:58 The iron test most doctors skip 48:31 Curcumin for mood and IL-6 57:02 The cheapest thing you can do for your brain Links Watch it on YouTube: https://youtu.be/yWFYfc80Q1U Full episode show notes: https://outliyr.com/272 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

What if the condition you've been managing for years is actually a deficiency nobody tested you for? Karen "Zuzu" Armes had her first seizure around age five. By 21 she was on three medications and carrying a bell to warn people when the next one was coming. Then she got pregnant, refused to expose her daughter to those drugs, and used food to taper off all three. She has been seizure-free for close to 40 years, and she now teaches what she learned to more than 45,000 people worldwide. Meet our guest Karen "ZuZu" Ziemer Armes is a holistic health educator, author, and speaker who co-founded Holistic Health Educators and Lilly Fields Retreat Center. She reversed her own epilepsy, scoliosis, and arthritis through holistic strategies, has delivered more than 2,500 seminars, and written four health books. Her work focuses on gut and cellular healing, sustainable energy, and integrative longevity. She describes herself as a kitchen hacker rather than a biohacker. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Most seizure activity traces back to a GABA deficiency, not an unexplained neurological disorder GABA is made primarily in the digestive system, and requires both an adequate pH and a diverse microbiome You carry 70 to 90 trillion bacteria, and Armes puts the beneficial share above 95% Your body cannot break down fiber at all, so the diversity of plant fibers matters more than the total amount Amino acids build proteins and proteins build enzymes, meaning one missing amino acid halts everything downstream Minerals are the single category the body cannot manufacture, which is why she covers them first Biofeedback units range from about $149 a month to $30,000, but the practitioner reading them matters more than the hardware Dietary change shows in the bloodstream within three days, though clearing dairy and gluten from the cells takes about three months Episode highlights 02:21 The GABA discovery that ended 3 medications 05:53 The hand sanitizer problem nobody talks about 14:17 Your body's pharmaceutical factory 20:21 Why "fortified" on a label is a red flag 29:16 What biofeedback actually is 42:07 The 4 changes that cost nothing 59:04 The food and emotion frequency chart Links Watch it on YouTube: https://youtu.be/V-MgexRjb5c Full episode show notes: https://outliyr.com/271 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick