The Human Upgrade: Biohacking for Longevity & Performance

The king is back! You probably recognize his name as the author of the famous book, Men Are From Mars, Women Are From Venus. But what's especially exciting is how John has evolved his insights to address the changing dynamics between men and women in the modern world, as he highlighted in his 2020 book, Beyond Mars and Venus: Relationship Skills for Today's Complex World.Now, why is this episode a must-listen? Well, John isn't just a relationship expert; he's also a seasoned biohacker who understands the profound impact of our environment – including relationships – on our hormones, happiness, and dopamine levels. In essence, he's been biohacking before it even had a name. With decades of wisdom, he offers invaluable insights into navigating the complexities of male-female relationships in today's world.Delve into the fundamental differences between men and women, the importance of appreciation in relationships, what truly motivates men, and practical tips on boosting testosterone and managing emotions. We also explore how men and women process feelings differently, the art of setting boundaries, and the language of love as the language of hormones.Get ready for a masterclass in understanding the dynamics of modern relationships and how to create lasting happiness.Timestamps:00:00 — Intro04:57 — Hormones Drive Relationships08:29 — Emotional Manipulation & Control20:42 — Detachment & The Cave31:37 — Listening Without Losing It39:49 — When Negativity Never Passes46:54 — Fasting & Testosterone Science01:04:23 — Languages of Love & Hormones01:14:54 — Surviving Public Attacks01:31:41 — Porn, Polarity & Reassurance01:44:00 — Wrap-UpThank You To Our Sponsors!Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighThe One Device | Use code DAVE for $10 off at theonedevice.com/daveViome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVEResources: • Learn More About John’s Work At: https://www.marsvenus.com/• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Timestamps:00:00 — Intro04:57 — Hormones Drive Relationships08:29 — Emotional Manipulation & Control20:42 — Detachment & The Cave31:37 — Listening Without Losing It39:49 — When Negativity Never Passes46:54 — Fasting & Testosterone Science01:04:23 — Languages of Love & Hormones01:14:54 — Surviving Public Attacks01:31:41 — Porn, Polarity & Reassurance01:44:00 — Wrap-UpSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Explore Calroy's vascular health and joint support supplements, including Arterosil, Vascanox, and Cartigenix, at https://calroy.com/dave Cartilage Regeneration, Joint Pain, Nitric Oxide, Blood Flow, Muscle Strength & Longevity with Kiran Krishnan Host Dave Asprey sits down with Kiran Krishnan, research microbiologist, systems biology researcher, and co-founder of Microbiome Labs, to explore cartilage regeneration, joint pain, osteoarthritis, nitric oxide, vascular health, inflammation, muscle growth, gut health, bone density, and the biological mechanisms that influence how the body ages. Kiran Krishnan is a research microbiologist, health and wellness expert, and entrepreneur who specializes in the human microbiome, gut health, inflammation, and systems biology. Over the past 20 years, he has founded several successful health and supplement companies, including co-founding and leading Microbiome Labs, a leading microbiome therapeutics brand among healthcare professionals. He is also a co-founder and partner in three other health companies. Kiran has conducted and published scientific research, contributed chapters to scientific textbooks, holds global patents, and is a sought-after speaker on human health and the microbiome. His latest work explores the relationship between blood vessel health, chronic inflammation, and the body's ability to repair damaged cartilage. Through research involving compounds designed to support vascular function, nitric oxide production, and joint health, Kiran is investigating whether age-related tissue degeneration can be slowed or potentially reversed. Dave opens the conversation by sharing his lifelong struggle with joint pain, including an arthritis diagnosis at age 14 and three knee surgeries. Kiran explains why cartilage degeneration may begin long before symptoms appear and how declining blood flow, damaged microvessels, and chronic inflammation can interfere with the body's natural cartilage repair mechanisms. They explore the role of the endothelial glycocalyx, the protective lining inside blood vessels, and why nitric oxide production becomes increasingly important with age. Kiran explains how impaired circulation can affect everything from joint lubrication and cartilage health to cognitive performance, digestion, muscle recovery, and sexual function. Kiran also discusses research involving Cartigenix, a joint support supplement developed using compounds from Boswellia and celery seed. He describes clinical trials involving patients with osteoarthritis, including reported improvements in joint pain, inflammation, and cartilage regeneration, even among older adults with advanced joint degeneration. Dave and Kiran examine how Cartigenix, Arterosil, and Vascanox target different aspects of joint and vascular health, while distinguishing the Cartigenix trial results from the proposed benefits of combining all three products. The conversation then shifts to practical strategies for improving circulation and metabolic health. Dave and Kiran discuss why walking after meals may help regulate blood sugar, how the cephalic response prepares the digestive system for food, and why excessive endurance exercise may create trade-offs for recovery and long-term health. They also challenge conventional thinking about muscle growth and longevity. Kiran explains why functional strength may matter more than muscle size, how nitric oxide and microcirculation influence the delivery of amino acids to muscle tissue, and why maintaining healthy blood vessels could be an overlooked factor in preserving strength as you age. Finally, Kiran previews emerging research on bone regeneration, gut health, and a new postbiotic-based formulation being developed for bone health, particularly during perimenopause and menopause. He shares early findings involving bone repair and osteocyte production, while Dave explains why maintaining strong bones, healthy joints, and efficient circulation should be foundational priorities for anyone interested in longevity. This episode is essential listening for anyone interested in cartilage regeneration, osteoarthritis, chronic joint pain, nitric oxide, blood circulation, vascular health, inflammation, muscle growth, strength training, gut health, bone density, menopause, cellular repair, supplements, biohacking, and the science of maintaining physical performance as you age. You’ll Learn: Why cartilage breaks down with age and how impaired blood flow and chronic inflammation interfere with joint repair What Kiran's clinical research suggests about cartilage regeneration and joint recovery in people with osteoarthritis How nitric oxide and the endothelial glycocalyx influence circulation, cardiovascular health, cognitive function, and longevity Why functional strength may be more important than muscle size for healthy aging, and how blood flow affects muscle growth and recovery How walking after meals, supporting digestion, and improving vascular function may benefit blood sugar regulation and gut health What emerging research suggests about bone regeneration, postbiotics, and maintaining bone density during menopause and aging Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Kiran Krishnan, Dave Asprey, The Human Upgrade, cartilage regeneration, cartilage repair, joint pain, osteoarthritis, arthritis, knee pain, joint health, bone on bone arthritis, Cartigenix, Calroy, Arterosil, Vascanox, nitric oxide, blood flow, vascular health, endothelial glycocalyx, chronic inflammation, Boswellia, muscle growth, muscle strength, strength training, muscle recovery, gut health, microbiome, bone density, bone regeneration, longevity, anti aging, biohacking  Resources: • Grab A Discount On Calroy's Vascular Health And Joint Support Supplements, Including Arterosil, Vascanox, and Cartigenix, at https://calroy.com/dave • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Thank you to our sponsors!      - ALP | Go to alppouch.com, code DAVE for 10% off. - Visit www.myvitalc.com/davesfav to unlock Dave’s discount - Our Place | Upgrade your kitchen with Our Place today. Visit fromourplace.com/DAVE and use code DAVE for 10% off sitewide. - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY. Timestamps:  00:00 — Trailer 01:05 — Intro 04:44 — The Glycocalyx Explained 10:30 — Why Joints Degrade 15:16 — Rebuilding Cartilage 21:17 — Nitric Oxide & Gut Health 26:28 — Hacking the Cephalic Response 31:23 — Strength vs. Size for Longevity 37:47 — Muscle Building Supply System 42:51 — New Bone Regeneration Product See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Infections Were Linked to About 1 in 8 Cancer Cases Worldwide A new global analysis estimates that infections were responsible for roughly 2.3 million new cancer cases in 2024, about 12% of all cancers worldwide. H. pylori and HPV were the largest contributors, followed by hepatitis B, Epstein-Barr virus, and hepatitis C. Host Dave Asprey explores how persistent infections can contribute to cancer through chronic inflammation, DNA damage, altered immune surveillance, and other biological pathways. He explains why this does not mean cancer is contagious or that infection inevitably leads to cancer, but argues that identifying, preventing, and treating infections such as H. pylori, hepatitis B, and hepatitis C can be an overlooked part of a long-term prevention strategy. Sources: -IARC: Global Burden of Cancer Attributable to Infections in 2024 -PubMed: Global Burden of Cancer Attributable to Infections in 2024 ~~~~ What We Really Know About Persistent Finasteride Side Effects Finasteride reduces the conversion of testosterone into DHT by inhibiting 5-alpha reductase, but that enzyme also participates in pathways involved in neuroactive steroids. Some former users report persistent sexual, cognitive, mood, and physical symptoms after stopping the drug, a collection of symptoms commonly called post-finasteride syndrome. Small studies have reported differences in neurosteroids, gene expression, androgen signaling, and peripheral nerve function among symptomatic former users, but these studies cannot establish that finasteride caused those changes or determine how common persistent symptoms are. Host Dave Asprey examines the evidence between the two extremes, neither dismissing persistent symptoms nor assuming that finasteride permanently damages everyone who takes it. European regulators have also recognized suicidal ideation as a possible adverse effect of oral finasteride, although its frequency remains unknown. Sources: -EMA: Finasteride and Dutasteride Safety Review -PubMed: Neuroactive Steroids After Finasteride Discontinuation PubMed: Neuroactive Steroids and Features in Post-Finasteride Patients PubMed: Differential Gene Expression in Post-Finasteride Syndrome ~~~ One Cup of Blueberries a Day Improved Measures of Vascular Function In a six-month randomized controlled trial involving 115 adults with metabolic syndrome, consuming the equivalent of one cup of blueberries per day improved endothelial function and a measure of arterial stiffness, while a half-cup dose did not produce the same effects. Host Dave Asprey explains why describing blueberries simply as “antioxidants” misses much of their biology. Anthocyanins and other polyphenols can interact with gut microbes and influence vascular, inflammatory, and nitric oxide-related signaling. He also examines a small smoothie experiment showing that the polyphenol oxidase found in bananas sharply reduced the circulating metabolites of certain flavan-3-ols, while emphasizing that the experiment did not prove bananas erase the benefits of blueberries. Sources: -American Journal of Clinical Nutrition: Blueberries and Cardiometabolic Function -Food & Function: Polyphenol Oxidase and Flavan-3-ol Bioavailability ~~~ Vitamin D Matters to Male Reproductive Biology, But It Is Not a Fertility Treatment Vitamin D receptors are present throughout the male reproductive system, and vitamin D signaling may influence processes involved in sperm motility and fertilization. Observational research has linked low vitamin D with poorer sperm motility, but clinical outcomes are less straightforward. In a randomized trial of 330 vitamin D-insufficient infertile men, supplementation raised vitamin D levels but did not improve overall semen parameters. Researchers observed potentially interesting signals involving spontaneous pregnancy and live birth among a subgroup of men with low sperm counts, but those findings require confirmation. Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense while arguing that male fertility needs to be evaluated as a larger system involving metabolic health, sleep, heat exposure, medications, hormones, micronutrients, toxins, oxidative stress, and semen testing. Sources: -PubMed: Vitamin D Supplementation, Semen Quality and Live Birth Rate ~~~ CoQ10 Shows Why a Great Mechanism Does Not Guarantee a Great Treatment CoQ10 plays a central role in mitochondrial energy production and electron transport, making it an appealing candidate for diseases involving mitochondrial dysfunction, oxidative stress, and neuronal energy failure. Early biological reasoning and smaller studies looked promising, but larger clinical trials have repeatedly failed to show the expected neurological benefits. A randomized trial of 600 people with early Parkinson’s disease found no evidence that high-dose CoQ10 slowed disease progression, while a large Huntington’s disease trial was stopped early for futility. A Phase II ALS trial also found insufficient evidence to justify moving to a larger Phase III study. Host Dave Asprey uses CoQ10 as a broader lesson in biohacking: a supplement can have a legitimate biological function while still failing to improve the clinical outcome you care about. Sources: -PubMed: High-Dose CoQ10 in Early Parkinson Disease -Neurology: CoQ10 in Huntington Disease -PubMed: Phase II CoQ10 Trial in ALS ~~~ This episode is designed for biohackers, longevity enthusiasts, men thinking about hair loss or fertility, and anyone trying to distinguish a compelling biological mechanism from a proven intervention. Host Dave Asprey examines how chronic infections contribute to cancer risk, what the evidence really says about persistent finasteride symptoms, why blueberries may influence vascular health through polyphenol signaling, where vitamin D fits into male fertility, and why CoQ10 is a powerful example of promising biology failing to translate into clinical outcomes. The larger lesson is simple: understand the mechanism, look for meaningful human outcomes, measure your own biology, and avoid confusing a plausible explanation with proof that an intervention works. Keywords: infection cancer risk, cancer causing infections, H pylori cancer, HPV cancer, Epstein Barr virus cancer, chronic infection cancer, finasteride side effects, post finasteride syndrome, finasteride neurosteroids, allopregnanolone finasteride, DHT hair loss, blueberries cardiovascular health, blueberries endothelial function, blueberry polyphenols, anthocyanins gut microbiome, banana smoothie polyphenols, polyphenol oxidase, vitamin D male fertility, vitamin D sperm quality, male infertility, CoQ10 mitochondria, CoQ10 Parkinson’s disease, CoQ10 neurodegeneration, mitochondrial health, biohacking research roundup Thank you to our sponsors!  - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body. - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com    Timestamps: 00:00 — Intro 00:45 — Infections From 2024 02:15 — Finasteride Concerns 04:38 — Blueberries and Bananas 06:40 — Vitamin D and Fertility 08:18 — CoQ10 Trial Failures 09:47 — Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Grab 20% off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E. Clean Living, Stress Reduction, Sleep, Skincare & Simple Wellness Habits with Miranda Kerr Host Dave Asprey sits down with Miranda Kerr, founder of KORA Organics, entrepreneur, model, and longtime wellness advocate, to explore clean living, stress, sleep, skincare, meditation, parenting, and why her approach to health has become simpler over time. Miranda shares how her mother’s cancer diagnosis when she was 16 changed the way her family looked at everyday ingredients and helped spark her lifelong interest in organic living, holistic health, and reducing unnecessary exposures. That experience later became a driving force behind KORA Organics and her focus on certified organic skincare. They explore the habits Miranda now prioritizes after years of experimenting with wellness, including morning sunlight, quality food, meditation, sleep, breathwork, strong relationships, and time with family. She also explains how she manages stress while raising four children and running an international company. Dave and Miranda discuss raising healthy kids without making health feel restrictive, navigating different health values within a family, and why acceptance matters when you cannot control another person’s choices. The episode also covers clean beauty, plant-based retinol alternatives, non-nano zinc sunscreen, essential oils, rose quartz, intention, and the philosophy behind KORA Organics. Miranda also explains why constantly chasing new wellness tools eventually pushed her back toward a smaller set of foundational habits that consistently make her feel better. This episode is essential listening for anyone interested in clean living, stress reduction, meditation, sleep, healthy parenting, skincare, organic beauty, biohacking, and building a wellness routine that supports your life rather than taking it over.  You’ll Learn: Why Miranda’s mother’s health scare changed the way she thought about food, skincare, and everyday ingredients Why her wellness routine has become simpler instead of more complicated over time The foundational habits Miranda prioritizes for energy, stress, sleep, and overall health How meditation, breathwork, morning sunlight, and evening light management fit into her daily routine How she teaches her children about healthy food without creating fear or restriction Why acceptance matters when your partner does not share the same health priorities How Miranda approaches clean beauty, organic skincare, retinol alternatives, and non-nano mineral sunscreen Why KORA Organics incorporates rose quartz, positive words, essential oils, and intention into its products How constantly experimenting with wellness tools can become counterproductive Why sunlight, sleep, food, relationships, and stress management remain the foundation even after years of exploring wellness Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Miranda Kerr, KORA Organics, clean living, clean beauty, wellness, healthy living, holistic health, skincare, organic skincare, certified organic skincare, healthy skin, anti-aging skincare, skin health, non-nano zinc sunscreen, mineral sunscreen, retinol alternative, bakuchi oil, meditation, TM meditation, breathwork, stress reduction, stress management, sleep, circadian rhythm, morning sunlight, blue light, grounding, healthy parenting, raising healthy kids, nutrition, toxins, environmental toxins, ingredient safety, essential oils, rose quartz, mindset, intention, biohacking, healthy aging, wellness routine, simple wellness, holistic wellness Resources: • Grab 20% Off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)  Thank you to our sponsors!      - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26. - LMNT | Right now, grab any LMNT drink mix and they'll throw in a free sample pack. Go to drinklmnt.com/dave to get yours. Timestamps:  00:00 — Trailer 00:51 — Miranda’s Health Awakening 06:21 — Mind, Body & Crystals 13:12 — Roots of Positive Thinking 17:04 — The McDonald's Birthday Hack 22:36 — Acceptance in Relationships 28:34 — Intention Behind the Products 32:28 — Proving Organic Skincare Works 36:56 — Stress & Morning Rituals 42:09 — Back to Basics 48:17 — Health Without Public Pressure 51:06 — Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Vagus Nerve Stimulation Improves Cognitive Scores in a Small Trial In a 24-week trial involving people with mild cognitive impairment, participants assigned to electrical stimulation at vagus-innervated parts of the ear improved by an average of 3.2 points on a general cognitive test, compared with 0.3 points in a sham-stimulation group. Host Dave Asprey explores the proposed connection between the vagus nerve and the locus coeruleus, a brainstem region involved in attention and learning. He explains why an improved test score is intriguing but does not show that vagus nerve stimulation prevents Alzheimer’s disease—or that a consumer device will reproduce the study’s results.pubmed.ncbi.nlm.nih+1 Sources: https://pubmed.ncbi.nlm.nih.gov/36150665/ https://pmc.ncbi.nlm.nih.gov/articles/PMC13214873/ https://theconversation.com/vagus-nerve-stimulation-shows-promise-as-a-way-to-counter-alzheimers-disease-and-age-related-memory-loss-269465 ~~~Nearly 500 Cat Tumors Reveal Cancer Genes Shared With Humans Researchers analyzed 493 matched tumor and normal-tissue samples across 13 types of cancer in domestic cats. They found alterations in genes familiar to human cancer researchers, including TP53, and tested whether a mutation called FBXW7 might predict drug sensitivity in lab-grown models of feline mammary tumors. Host Dave Asprey examines why naturally occurring cancers in pets could help scientists investigate treatments across species, while making clear that a promising response in six laboratory tumor models is not a proven treatment for cats or people.pmc.ncbi.nlm.nih Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC7618901/ https://pubmed.ncbi.nlm.nih.gov/41712721/ https://www.sciencedaily.com/releases/2026/09/260924231826.htm ~~~Twin-Family Study Challenges a Simple Explanation for Inherited Intelligence Why do parents and children often score similarly on tests of cognitive ability? Researchers using Germany’s TwinLife data found that genetic transmission explained more of that resemblance than the particular shared-home-environment pathway their model tested. Host Dave Asprey unpacks the distinction between why relatives resemble one another and whether a child’s environment matters. The study does not show that parenting, education, or other experiences have no effect on cognition.pub.uni-bielefeld+1 Sources: https://pub.uni-bielefeld.de/record/2993432 https://www.psypost.org/genetics-not-shared-environments-drives-parent-child-similarities-in-cognitive-ability/ ~~~Mulberry Compounds May Change Gut Bacteria and Metabolism A review of mulberry research highlights how leaves, fruit, and differently processed extracts contain distinct mixtures of compounds that gut microbes may use. In mouse experiments, a fraction combining mulberry polyphenols and polysaccharides produced more favorable microbiome and metabolic changes than either fraction alone; transferring microbes from treated mice passed along some of those effects. Host Dave Asprey explores the idea that a plant extract’s preparation may matter as much as its name—and why the findings do not yet establish a microbiome benefit from mulberry products in humans.pmc.ncbi.nlm.nih+1 Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC13406227/ https://www.sciencedaily.com/releases/2026/09/260928100551.htm ~~~Magnesium Changes Vitamin D Metabolism—But Not Always in the Same Direction Magnesium helps regulate the pathways that process vitamin D, but “more magnesium means more vitamin D” is too simple. In a 12-week randomized trial involving 180 adults, magnesium supplementation changed a measured vitamin D metabolite differently depending on participants’ starting vitamin D levels: the modeled difference was positive at 30 ng/mL and negative at 50 ng/mL. Host Dave Asprey explains why this matters to people tracking supplement stacks and bloodwork, while distinguishing a change in a lab marker from a demonstrated health benefit.pubmed.ncbi.nlm.nih+1 Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC6693398/ https://pubmed.ncbi.nlm.nih.gov/29480918/ https://www.sciencedaily.com/releases/2018/02/180226122548.htm This episode is designed for biohackers, longevity enthusiasts, pet owners, parents, and anyone trying to separate a compelling biological mechanism from a proven health intervention. Host Dave Asprey examines brain stimulation and memory, what cat cancers could teach human researchers, how genes and environment contribute to cognitive similarity, whether mulberry’s microbiome effects translate beyond mice, and why nutrient interactions are rarely as simple as a supplement headline suggests. Several studies discussed here predate this week’s coverage; this is a research roundup, not a list of five newly published trials.pmc.ncbi.nlm.nih+4 New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: vagus nerve stimulation memory, auricular vagus nerve stimulation, mild cognitive impairment, Alzheimer’s research, locus coeruleus, cat cancer genetics, feline oncogenome, FBXW7 feline mammary cancer, comparative oncology, parent child cognitive ability, TwinLife cognitive ability study, intelligence genetics, shared environment cognition, mulberry gut microbiome, mulberry polyphenols polysaccharides, microbiota transfer mice, magnesium vitamin D metabolism, magnesium supplementation vitamin D, biohacking research roundup Thank you to our sponsors!  - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 — Intro 00:18 — Vagus Nerve 01:51 — Cat Cancer 03:53 — Genetics & Parenting 05:46 — Mulberries 07:43 — Magnesium & Vitamin D 09:25 — Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode. Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and de-liver-ance, to explore why the liver may be one of the most overlooked organs in metabolism, hormone health, detoxification, brain function, weight management, and longevity. Siggi explains why fatty liver can develop without obvious symptoms and why someone can appear lean and healthy while still have significant liver fat. Drawing on thousands of liver scans, he shares what his team has observed in people whose blood markers appeared normal despite signs of fatty liver on imaging, and explains how tools such as FibroScan can reveal liver fat, stiffness, and fibrosis. Dave and Siggi go deep into triglycerides, cholesterol, insulin resistance, brain fog, weight gain, bile production, thyroid hormone activation, testosterone, estrogen metabolism, and liver regeneration. They also explore how alcohol, environmental chemicals, plastics, processed foods, artificial sweeteners, medications, and other exposures may place additional stress on the liver. The conversation also tackles rapid weight loss and GLP-1 medications, including Siggi’s concerns about compounds released from fat tissue during aggressive weight loss and why protecting muscle, eating enough protein, and supporting liver function may matter during the process. Dave and Siggi also discuss alcohol, estrogen, hormone replacement therapy, glutathione, choline, bile flow, supplement quality, and why liver health may influence systems throughout the body. The episode takes an unexpected turn into microchimerism and organ transplantation, including donor cells, DNA, cellular memory, and reported changes in behavior or personality after transplantation. This is essential listening for anyone interested in fatty liver, metabolic health, GLP-1s, weight loss, hormone health, estrogen, testosterone, thyroid function, alcohol, brain fog, insulin resistance, liver scans, longevity, choline, glutathione, bile flow, and biohacking. You’ll Learn: Why fatty liver can develop even in people who are thin or rarely drink alcohol Why normal bloodwork may not always reveal what is happening inside the liver How liver health connects to metabolism, brain fog, weight gain, hormones, and thyroid function What rapid weight loss and GLP-1 use may mean for liver function How alcohol, estrogen, HRT, bile, choline, and glutathione interact with liver health Why liver scans, nutrition, and supplement quality may matter for long-term health Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Siggi Clavien, de-liver-ance, The Liver Clinic, liver health, fatty liver, fatty liver disease, MASLD, liver detox, liver function, liver scan, FibroScan, liver fibrosis, triglycerides, cholesterol, metabolic health, GLP-1, weight loss, toxins, alcohol, estrogen, HRT, testosterone, thyroid health, brain fog, insulin resistance, bile, choline, glutathione, artificial sweeteners, supplements, longevity, liver regeneration, microchimerism, biohacking Resources:    • Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     Thank you to our sponsors!      - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE. - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Mars Men | For a limited time, our listeners get 50% off for life plus Free Shipping AND 3 Free Gifts when you checkout at MenGoToMars.com. Timestamps:  00:00 — Trailer 01:00 — Liver Basics & Signs 05:30 — Liver Scan Technology 08:15 — Chemicals & Liver Disease 11:30 — Deliverance Formula Story 17:15 — Estrogen, Alcohol & HRT 22:30 — GLP-1s & Liver Toxicity 28:00 — Bile & Gut Health 33:10 — Chimerism & Transplants 41:30 — Hormesis & Painkillers 50:00 — Sweeteners, Hormones & Thyroid 55:00 — Outro - Discount See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Novo Nordisk Eyes Hair-Loss Market in Consumer-Health Expansion Novo Nordisk, the company behind Ozempic and Wegovy, is exploring hair loss as one of several possible areas for future expansion, alongside menopause and addiction. The company has not announced a hair-loss drug, clinical trial, acquisition, or partnership, but Chief Scientific Officer Martin Holst Lange pointed to the category during the company's 2026 Capital Markets Day. Host Dave Asprey breaks down why hair loss makes strategic sense for a company already deeply involved in endocrine biology, how emerging treatments are moving beyond traditional options like minoxidil and finasteride, and why sudden shedding during rapid GLP-1 weight loss may be telogen effluvium rather than traditional pattern baldness. Sources: https://www.bloomberg.com/news/articles/2026-09-22/ozempic-maker-novo-looks-to-target-hair-loss-in-consumer-push https://www.novonordisk.com/investors/capital-markets-day-2026.html https://www.irishexaminer.com/business/companies/arid-41914219.html ~~~Nearly One in Six Pediatric GLP-1 Users Diagnosed With a Nutritional Deficiency A study of 2,031 children and adolescents ages 10 to 17 who were prescribed GLP-1 receptor agonists found that 16.88% received a new diagnosis related to a nutritional deficiency within one year. Vitamin D deficiency was the most common, appearing in about 12.4% of the group, while smaller numbers were diagnosed with nutritional anemia or iron deficiency anemia. Host Dave Asprey explains why the study does not prove GLP-1 drugs caused these deficiencies, but highlights a bigger concern: only about 5% of the children had documented nutrition counseling within the first 30 days, even though appetite suppression during adolescence can reduce intake of protein, iron, calcium, vitamin D, B vitamins, and other nutrients needed for growth. Sources: https://doi.org/10.1177/21532176261486979 https://www.sciencedaily.com/releases/2026/09/260923035926.htm https://pharmaceutical-journal.com/article/news/children-taking-glp-1s-can-be-at-risk-of-nutritional-deficiencies-study-finds ~~~Stronger Stomach-Brain Synchrony Associated With Poorer Mental Health Researchers studying the electrical rhythm of the stomach alongside brain activity found an unexpected relationship: stronger synchronization between gastric signals and certain brain networks was associated with worse mental health measures, including higher anxiety, depression, stress, and fatigue. The strongest associations appeared in networks involved in attention and cognitive control. Host Dave Asprey explains why the findings do not prove stomach-brain synchronization causes mental health problems, but expand the gut-brain conversation beyond the microbiome to include electrical activity, neural signaling, hormones, immune pathways, and metabolites. Sources: https://www.nature.com/articles/s44220-025-00468-6 https://health.au.dk/en/display/artikel/the-stomachs-brain-is-more-in-sync-with-the-mind-during-mental-distress https://medicalxpress.com/news/2025-08-stomach-brain-sync-mind-mental.html ~~~Food Preservatives and Additive Mixtures Associated With Cardiovascular Risk A large French NutriNet-Santé study involving more than 112,000 adults found that higher exposure to total preservatives was associated with a higher incidence of hypertension, while several individual additives were also linked to elevated risk. A newer September 2026 analysis from the same cohort examined combinations of additives people commonly consume together and found several mixtures associated with higher rates of hypertension, cardiovascular disease, or coronary heart disease. Host Dave Asprey explains why these observational findings cannot prove that preservatives cause cardiovascular disease, but raises a larger question about whether evaluating food additives one compound at a time accurately reflects the mixtures people consume in real packaged foods. Sources: https://academic.oup.com/eurheartj/article/doi/10.1093/eurheartj/ehag308/8679203 https://link.springer.com/article/10.1186/s12916-026-05132-z https://www.escardio.org/news/press/press-releases/common-food-preservatives-linked-to-high-blood-pressure-and-heart-disease/ ~~~Taurine Pretreatment Reduces Depression-Like Changes in Chronically Stressed Rats A 2017 study in male rats found that taurine pretreatment reduced several behavioral and biochemical effects of chronic unpredictable stress. Taurine-treated animals maintained more normal reward-seeking behavior and performed better on some learning and memory measures, while researchers also observed changes in corticosterone, glutamate, serotonin, dopamine, noradrenaline, BDNF, and FGF2. Host Dave Asprey explains why this does not show that taurine treats depression in humans, especially because the taurine was injected and given before the chronic stress began, but uses the study to explore a broader principle: much of stress resilience may be built before the stress ever arrives. Sources: https://www.nature.com/articles/s41598-017-05051-3 https://pmc.ncbi.nlm.nih.gov/articles/PMC5504064/ This episode is designed for biohackers, longevity enthusiasts, parents, and high-performance listeners who want emerging health research translated into practical decisions without getting trapped by headline science. Host Dave Asprey explores what rapid weight loss can mean for hair and nutrient status, why the gut-brain axis extends far beyond the microbiome, what food-additive research can and cannot tell us about cardiovascular risk, and why stress resilience may depend as much on what you do before a challenge as what you do after it. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Novo Nordisk hair loss, Ozempic hair loss, Wegovy hair shedding, GLP-1 telogen effluvium, minoxidil hair loss, finasteride hair loss, pediatric GLP-1 nutritional deficiencies, GLP-1 vitamin D deficiency, GLP-1 children nutrition, liraglutide adolescents, semaglutide teenagers, stomach brain connection, gastric brain coupling, gut brain axis mental health, electrogastrography anxiety, gut brain depression, food preservatives cardiovascular disease, food additives hypertension, NutriNet-Santé preservatives, ultra-processed foods heart disease, additive mixtures cardiovascular risk, taurine stress resilience, taurine depression study, taurine BDNF, chronic stress taurine, biohacking news 2026 Thank you to our sponsors!  - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 — Intro 00:18 — Novo Nordisk & Hair Loss 02:52 — GLP-1s & Kids' Nutrition 05:08 — Stomach-Brain Sync 07:49 — Preservatives & Heart Risk 10:53 — Taurine & Stress Resilience 13:28 — Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Catharine Arnston on Spirulina, Chlorella, Mitochondria, Detox, Brain Energy, and Longevity Visit https://energybits.com/ and use code HUMANUPGRADE for 20% off. Could one of the oldest foods on Earth also be one of the most overlooked tools for mitochondrial health, brain function, detoxification, and longevity? Host Dave Asprey sits down with Catharine Arnston, founder of ENERGYbits and author of Love Your Health to Bits with Algae, to explore the biology of spirulina and chlorella and why these microscopic organisms have been studied for decades as unusually nutrient-dense foods. Catharine explains the major differences between spirulina and chlorella, from how they are grown and processed to how she uses them for completely different purposes. Spirulina contains compounds including phycocyanin and superoxide dismutase that Catharine believes can support mitochondrial function, antioxidant defenses, cellular energy, and brain health, while chlorella is used primarily for binding and removing unwanted compounds such as heavy metals. They also discuss why water quality, sourcing, drying temperature, and processing can dramatically change the final product. The conversation goes deep into mitochondrial biology, including the electron transport chain, ATP production, oxidative stress, free radicals, cytochrome c, superoxide dismutase, and the blue pigment phycocyanin. Dave connects these mechanisms to his own experience rebuilding mitochondrial function and explains why increasing cellular energy without adequate antioxidant defenses may create problems, particularly for people experimenting with advanced longevity interventions such as mitochondrial peptides. Dave and Catharine also explore methylene blue, psychedelics, exercise, brain aging, environmental toxins, nutrient density, food quality, algae farming, sustainable agriculture, and why maintaining mitochondrial function may become increasingly important with age. Catharine, who turns 70 shortly after the recording, also shares the philosophy behind her first book and her belief that aging does not have to mean accepting declining energy and cognitive function. This is essential listening for anyone interested in mitochondria, spirulina, chlorella, cellular energy, brain health, detoxification, oxidative stress, longevity, biohacking, nutrient density, methylene blue, peptides, and maintaining performance as you age. You’ll Learn: Why spirulina and chlorella work differently in the body How spirulina may support mitochondrial energy and antioxidant defenses Why chlorella is commonly used for heavy metal and toxin binding What phycocyanin and superoxide dismutase do inside cells How oxidative stress can disrupt mitochondrial energy production Why Dave cautions against pushing mitochondrial output without adequate cellular protection How algae may support brain health, longevity, and performance as you age  Dave Asprey is 4x NY Times Bestselling Author, Longevity Expert and Creator of the Biohacking Movement. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Catharine Arnston, ENERGYbits, spirulina, chlorella, algae, microalgae, mitochondrial health, mitochondria, cellular energy, ATP production, electron transport chain, oxidative stress, free radicals, superoxide dismutase, SOD, phycocyanin, brain health, detoxification, heavy metals, glyphosate, environmental toxins, methylene blue, MOTS-c, peptides, biohacking, longevity, healthy aging, nutrient density, antioxidant defense, sustainable food Resources:    • Visit https://energybits.com/ and use code HUMANUPGRADE for 20% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     Thank you to our sponsors!      - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Our Place | Upgrade your kitchen with Our Place today. Visit fromourplace.com/DAVE and use code DAVE for 10% off sitewide. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Timestamps:  00:00 — Show Open 01:25 — Algae Origins & History 06:15 — Sourcing Quality Algae 09:15 — Nutrient Density Crisis 17:15 — Spirulina vs. Chlorella 22:30 — Algae Industry Applications 27:45 — Algae in Your Cells 33:20 — SOD & Brain Health 42:00 — Phycocyanin & Cancer 52:30 — Aging vs. Declining See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Back with another all-time classic. Teal's is one of those episodes I keep going back to because it was just that good. Now more than ever, we need to ask ourselves: what is the role of Ego? Do we need to worry about AI killing us? Is there hope for the future of our species?These are just a few of the big questions you’ll tackle in this enlightening and esoteric episode re-run. I’m joined by Teal Swan, a thought leader, bestselling author, and international speaker who is on a mission to reduce human suffering. After a challenging upbringing, Teal emerged with a unique ability to talk about psychology, shadow work, and the nature of our world. Teal shares the unusual and special way she sees the world. We talk about her ESP powers, how to identify a narcissist, and her favorite dimensions. We also get into the divine masculine vs. the divine feminine, the nature of ego, and how to build trust in the world and others. 00:00 — Trailer00:18 — Intro6:12 — Understanding Narcissism13:20 — AI and Spiritual Perception19:30 — Birth Trauma and Memory28:00 — Art and Different Realities35:22 — The Nature of Ego42:50 — Divine Masculine and Feminine50:00 — Hormones and Hope54:05 — Synchronization Workshops1:00:29 — OutroSponsorsButcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighEMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVEResources: • Learn More About Teal's Work At: https://tealswan.com/about-teal/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

**Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation!**At 53, Josh Duhamel says he feels better than he did in his 30s. Host Dave Asprey sits down with actor and Gatlan Health founder Josh Duhamel to talk testosterone, peptides, nootropics, brain health, fatherhood, and what it takes to stay strong as you age. Josh shares why he started TRT in his early 40s, what changed once he began tracking his hormones, and why he decided to build a health company around hormone optimization. They also discuss injectable testosterone, GLP-1s, peptide quality, hair loss treatments, stem cells, and the importance of medical guidance when experimenting with longevity tools. The conversation also gets into cognitive performance, including Josh's past struggles with forgetting lines, his interest in nootropics, and Dave's experience with Modafinil and Aniracetam. Josh explains why having a newborn and a toddler at 53 has made longevity more personal, while Dave and Josh explore the connection between physical health, spirituality, breathwork, psychedelics, and mental performance. This is essential listening for anyone interested in testosterone, TRT, peptides, nootropics, brain health, GLP-1s, healthy aging, fatherhood, hormone optimization, and longevity. You'll Learn: Why Josh started testosterone therapy in his early 40s How TRT changed his energy, strength, joints, and motivation Why testosterone levels should be individualized How injectable, oral, and topical testosterone differ Why peptide sourcing matters How GLP-1s can affect muscle and body composition What Josh has tried for hair loss Why brain performance became a major concern for him Which nootropics come up for memory, focus, and mental stamina Why becoming a father later in life changed how Josh thinks about longevity How breathwork, psychedelics, and spirituality fit into the conversation Thank you to our sponsors!      - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY. - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE. - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Josh Duhamel, Gatlan Health, testosterone therapy, TRT, low testosterone, hormone optimization, injectable testosterone, testosterone cream, oral testosterone, peptides, peptide therapy, GLP-1, healthy aging, longevity, nootropics, Modafinil, Aniracetam, Dihexa, brain health, cognitive performance, hair loss, stem cells, fatherhood, men over 50, energy, muscle, strength, bloodwork, hormone testing, psychedelics, breathwork, spirituality Resources:    • Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     Timestamps:  00:00 – Trailer 01:15 – Intro 07:16 – Alcohol & Hangover Hacks 13:24 – Spirituality & Health 19:36 – Hormone Therapy for Women 24:45 – Inside Gatlan's Model 30:35 – Potty Training Secrets 38:39 – North Dakota & Fargo 43:57 – Hollywood's Beauty Secrets 50:19 – Acting Career & Longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Try Longevity Gummies: https://www.timeline.com/partners/dave-aspreyThis video walks you through the complete biological timeline of a 36-hour sugar fast, from insulin dropping and liver glycogen draining to fat burning, ketone production, lower inflammation, and sharper mental clarity. You’ll see how quickly your metabolism can start switching back to the fuel system it was built to use.Thank you to our sponsors!Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighBrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power BundleiRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE00:00 – Sugar's Deadly Toll01:31 – Insulin's Hidden Damage02:52 – The Glycogen Reserve04:12 – Liver Fuel Runs Low05:29 – Reversing Insulin Resistance07:30 – Brain's Fuel Problem07:53 – Ketones: Backup Fuel09:24 – The Hormonal Reset10:46 – Visible Physical ChangesConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Karan Rajan on Fiber Fermentation, Sodium Myths, and What Your Poop Reveals About Disease Risk Your poop is more predictive than almost any other health signal, and you are flushing that data away every single day without a second look. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Karan Rajan, a practicing NHS gastrointestinal surgeon, best-selling author, and Chief Science Officer at Throne, who has built a following of over 12 million people by making gut science accessible and actionable. He has spent his career removing colon cancers, treating digestive disease, and now studies how gut bacteria drive nearly every system in the body, from hormone metabolism to brain optimization. They break down why fibermaxxing can backfire without the right mix of fast, medium, and slow fermenting fibers, and why generic "eat more fiber" advice ignores what your gut bacteria actually need. The conversation covers protein absorption limits and how much your body can really use, the truth about saturated fat and metabolism, and why the sodium-to-potassium ratio matters more than sodium alone. They also dig into fasting and the gut's natural cleaning cycle, the estrobolome and testobolome and their role in hormone balance and longevity, and how AI is starting to reshape personalized health data, supplements, and functional medicine. Dr. Rajan shares some of the strangest objects he has surgically removed from patients, and explains what your poop's color, shape, and consistency reveal about liver function, inflammation, and disease risk long before symptoms show up anywhere else. This is essential listening for anyone serious about biohacking, gut health, human performance, longevity, mitochondria function, nootropics, ketosis, carnivore and fiber-based diets, sleep optimization, anti-aging, and hacking your metabolism from the inside out. You'll Learn: Why fibermaxxing can cause bloating instead of better gut health The real difference between fast, medium, and slow fermenting fibers How much protein your gut can actually absorb and digest Why low sodium may be more dangerous than high sodium for most people How fasting triggers your gut's natural cleaning cycle, the migrating motor complex What your poop's color and consistency can reveal about liver and metabolic health How gut bacteria influence hormone metabolism through the estrobolome and testobolome Where AI and functional medicine are headed in personalized gut health tracking  Thank you to our sponsors!      - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide. - Caldera + Lab | Go to calroy.com/dave for the research, a discount, and a 45-day money back guarantee. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Karan Rajan, gut surgeon, fibermaxxing, gut microbiome, Bristol stool chart, poop health, Throne, fermentation geography, soluble fiber, insoluble fiber, prebiotics, inulin, oxalates, estrobolome, testobolome, migrating motor complex, sodium potassium ratio, saturated fat, ghee, collagen, protein absorption, keto, carnivore, fasting, gut bacteria, flatulence science  Resources:   • Dr. Karan's Newsletter: https://drkaran.kit.com • Learn more about Throne - https://www.thronescience.com/• Check Out Dr. Karan’s YouTube: https://www.youtube.com/c/DrKaran • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    Timestamps:  00:00 – Trailer 00:55 – Meet Dr. Karan Rajan 04:04 – Kellogg's History & Farts 11:53 – Throne Poop Tracking 19:35 – Poop Colors & Wild Stories 28:02 – Worst Foods & Saturated Fat 36:26 – Fiber Fermentation Geography 46:57 – Sodium & Salt Myths 59:03 – Keto, Carnivore & Fasting 01:04:45 – AI, Misinformation & Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.