ZOE Science & Nutrition

Could inflammation be causing low mood, anxiety, depression, or even affecting your risk of dementia? Emerging science suggests that inflammation in the body may change how the brain works. In this episode, Ed Bullmore, a Professor of Psychiatry at King's College London and a leading voice in brain research, explores why feeling low, emotionally flat, foggy or exhausted may not always be “all in your head”. Ed explores emerging science suggesting that inflammation in the body may alter how the brain works. He explains how inflammation can influence the brain and discusses why obesity, gut health, gum disease, menopause, ageing and stress may all play a role. He also examines why medicine has traditionally separated physical and mental health, and what this may mean for understanding the root causes of low mood. By the end of the episode, you’ll have some practical ways to support both brain and body health. Ed shares the evidence behind which exercise and diet matter most, and why discussing mental and physical health together may help you get closer to the causes of your symptoms. If your mood, energy and brain health are shaped by more than what’s happening in your mind, what might your body be trying to tell you? 🌱 Try our science-backed and tasty wholefood supplement Daily30 Get our brand-new app and Gut Health Test designed by world-leading gut health and nutrition scientists to build healthy eating habits 👉 Join ZOE Follow ZOE on Instagram.

Could mushrooms hold the secret to better gut health, lower cholesterol, and can they protect your brain? Today, Professor Robin May, a leading microbiologist and the UK Government’s Chief Scientific Officer, explores why our interest in mushrooms has exploded. He explains why they are not just another vegetable but could hold the key to better gut health, brain health, immune health, and lower cholesterol. By the end of the episode, you’ll know which health claims about mushrooms are real, which are exaggerated and where the science is just too early to trust. You’ll have a solid understanding of what mushrooms are really doing inside our bodies and how to unlock the secret health powers they hold. Should mushrooms become a regular part of your weekly shop rather than an occasional side dish? And if fungi have evolved alongside humans for millions of years, what else might they reveal about the future of nutrition and health? 🌱 Try our science-backed and tasty wholefood supplement Daily30 Get our brand-new app and Gut Health Test designed by world-leading gut health and nutrition scientists to build healthy eating habits 👉 Join ZOE Follow ZOE on Instagram. Timecodes 00:00 Intro 03:32 Are mushrooms closer to humans than plants? 06:20 What is a mushroom, really? 10:46 Why we’re eating more mushrooms now 12:14 The hidden nutrients inside mushrooms 13:56 Can mushrooms boost vitamin D? 15:35 The sunlight trick for healthier mushrooms 17:27 How many mushrooms give you enough vitamin D? 18:01 The mushroom with 500x more vitamin D 20:25 The mystery compound found in mushrooms 22:00 Should you take mushroom supplements? 24:30 Do all mushrooms contain this rare compound? 26:22 Can mushrooms help you live longer? 28:35 Can lion’s mane protect your brain? 30:24 Do mushrooms really boost IQ? 34:21 Can mushrooms affect your immune system? 36:40 How mushrooms feed your gut microbes 38:20 Should fungi live in your gut? 39:45 The fungus that lives on your head 41:50 Can mushrooms lower cholesterol? 43:21 Are you cooking mushrooms wrong? 45:25 Should you eat raw mushrooms? 47:21 How to make mushrooms taste better 49:25 The easiest way to eat more mushrooms 52:17 Robin’s top mushroom tip 📚Books by our ZOE Scientists The Food For Life Cookbook Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Ferment by Prof. Tim Spector Good Mood Food (preorder) by Prof. Tim Spector Free resources from ZOE The Hormone Harmony Guide: Tuning Your Body’s Internal Orchestra Eating for Better Brain Health: Your brain-gut blueprint How to eat in 2026 - Discover ZOE’s 8 nutrition principles for long-term health Live Healthier: Top 10 Tips From ZOE Science & Nutrition Gut Guide - For a Healthier Microbiome in Weeks Better Breakfast Guide Mentioned in today's episode A Review of Mushrooms as a Potential Source of Dietary Vitamin D, Nutrients (2018) Ergothioneine: an underrecognised dietary micronutrient required for healthy ageing, British Journal of Nutrition (2023) Ergothioneine: A Stress Vitamin with Antiaging, Vascular, and Neuroprotective Roles?, Antioxidants and Redox Signaling (2022) Mushrooms & longevity, Nature (2025) Lion’s mane & nerve growth factor, Journal of Biological Engineering (2023) The Relationship between Mushroom Intake and Cognitive Performance, Nutrients (2024) Have feedback or a topic you'd like us to cover? Let us know here. Episode transcripts are available here.

If you feel like you can’t stop eating, constantly crave junk food, or struggle with overeating, this episode will change how you see food. Michael Pollan, one of the world's most influential science writers, joins Professor Tim Spector to explain how ultra-processed food may drive food addiction, override fullness signals, and keep us craving more. Together, they explore why foods high in sugar, salt, and fat can feel so hard to resist, and what we can do to fight back. Michael and Tim unpack how the modern food system changed over the last 50 years, and why many ultra-processed foods are designed around “craveability.” They explain how these foods may stimulate the brain’s reward systems, why fibre and plants help us feel fuller, and why cooking more meals at home may help reduce overeating without calorie counting. The episode includes practical ways to regain control of your eating habits, reduce cravings, feel better and live more healthy years. If your cravings feel impossible to control, is it really a lack of willpower, or is modern food engineered to keep us coming back for more? 🌱 Try our science-backed and tasty wholefood supplement Daily30 Get our brand-new app and Gut Health Test designed by world-leading gut health and nutrition scientists to build healthy eating habits 👉 Join ZOE Follow ZOE on Instagram. Timecodes 00:00 Intro 04:04 How monoculture changed modern food 08:52 Are we basically made of corn? 12:58 The 3 ingredients engineered to drive cravings 14:32 Why ultra-processed food keeps you hungry 15:44 Why governments subsidize junk food 18:01 How fast food changed family cooking 20:00 Is ultra-processed food destroying family meals? 21:46 What happens when you stop eating plants? 22:55 Your gut microbes are eating too 25:31 Caffeine and the world’s most used drug 26:26 Michael Pollan quits caffeine for 3 months 28:35 Is caffeine addiction actually harmful? 29:11 Coffee and heart disease risk explained 32:34 Why workplaces normalized caffeine 33:40 The simplest way to stop overeating 35:30 Did food companies convince us cooking is hard? 37:02 How to identify ultra-processed food 38:25 Michael Pollan’s famous food rule explained 40:14 Why “plant-based” doesn’t always mean healthy 42:46 The Japanese habit that may reduce overeating 44:24 How food companies engineer craveability 45:25 Are food companies manipulating your cravings? 46:41 Why eating 30 plants a week matters 47:36 Eat food, not too much, mostly plants

10 million deaths a year. That is how many people are predicted to die from antibiotic-resistant infections if we do not find new treatments. In today’s episode, Professor Martha Clokie and Professor Tim Spector explore the secret gut viruses, known as phages, being studied to fight deadly infection, target cancer cells, and to protect your gut microbiome. Martha is a world-leading expert on the mysterious phage and, for the last 20 years, has pioneered research to revolutionise the treatment of infections without antibiotics. She explains why antibiotic resistance is a growing global threat, why everyday infections are becoming harder to treat, and how some bacteria are now resistant to every antibiotic available. We explore how the viruses in our gut may help solve this problem, and how scientists may one day use them to deliver highly targeted cancer treatment. By the end of the episode, you’ll have some ideas to help support a healthier gut ecosystem and understand how to increase the number of friendly gut viruses that live inside you. The science is still early, but the message is clear: the small choices we make every day are shaping our long-term resilience to disease. If viruses can help protect us from infection rather than cause it, how much of human health are we only just beginning to understand? 🌱 Try our science-backed and tasty wholefood supplement Daily30 Get our brand-new app and Gut Health Test designed by world-leading gut health and nutrition scientists to build healthy eating habits 👉 Join ZOE Follow ZOE on Instagram. Timecodes 00:00 Intro 01:34 The gut viruses scientists say we need to survive 03:19 There are more gut viruses than stars in the universe 10:50 The billion-year war happening inside your gut 13:10 The hidden system controlling your microbiome 14:42 What healthy microbiomes have that unhealthy guts lose 16:33 The gut viruses that may protect you from infection 17:38 Why your immune system allows trillions of viruses to live inside you 19:25 The natural viruses that kill salmonella 20:52 Why ageing may weaken your gut’s viral defences 22:05 Scientists still don’t know what most gut viruses do 25:12 The strange origin story of phage therapy 27:22 Doctors are already using viruses to treat deadly infections 28:02 Why antibiotics are starting to fail 29:07 The deadly infection crisis bigger than cancer 30:38 How factory farming fuels antibiotic resistance 32:27 The antibiotic resistance emergency is already here 33:25 The forgotten treatment abandoned after antibiotics 35:50 Why phage therapy may spare your microbiome 36:37 The dying patient saved by experimental viruses 39:41 Could phages replace antibiotics in the future? 40:50 The viruses scientists are using to target cancer cells 44:35 How diet shapes the viruses living in your gut 46:05 The surprising link between coffee and gut health 47:25 The foods that may increase healthy gut viruses 50:34 The future of gut health, cancer treatment and infection prevention 📚Books by our ZOE Scientists The Food For Life Cookbook Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Ferment by Prof. Tim Spector Good Mood Food (preorder) by Prof. Tim Spector Free resources from ZOE The Hormone Harmony Guide: Tuning Your Body’s Internal Orchestra Eating for Better Brain Health: Your brain-gut blueprint How to eat in 2026 - Discover ZOE’s 8 nutrition principles for long-term health Live Healthier: Top 10 Tips From ZOE Science & Nutrition Gut Guide - For a Healthier Microbiome in Weeks Better Breakfast Guide Mentioned in today's episode How gut viruses shape your gut microbiome Phages to the rescue, Trends in Microbiology (2024) Compounds in the foods we eat can trigger phage production, Gut Microbes (2020) Microbiomes of garden vs supermarket produce, Nature (2022) Phage Therapy at Belgium’s Queen Astrid Military Hospital, Viruses (2019) Habitual coffee intake shapes the gut microbiome, Nature (2026) Have feedback or a topic you'd like us to cover? Let us know here.Episode transcripts are available here.

Allergies have tripled - with hay fever, seasonal allergies, eczema and food intolerances now affecting millions of people. But why are allergy symptoms getting worse, and what does gut health have to do with it? In this episode, Adam Fox, a world-leading allergy Professor at King’s College London, explains why allergies may be rising so fast, why many beliefs about allergies are wrong, and what new science reveals about your immune system, skin and gut. Professor Fox explores why some foods are more likely to trigger reactions, and why modern allergy science is increasingly focused on gut health. Adam also discusses why 90% of people told they are allergic to certain things may not actually be allergic, the difference between allergies and intolerances, and why some antihistamines may be doing you more harm than you realise. By the end of this episode, you will have some practical ways to manage hay fever and seasonal allergies, including which antihistamines experts now recommend avoiding, simple ways to reduce pollen exposure at home, and when allergy testing or desensitisation treatment may help. Adam explains how newer treatments are starting to retrain the immune system rather than simply suppress symptoms. If allergies barely existed a few hundred years ago, what changed? And could your gut now be shaping the way your immune system reacts to the world around you? 🌱 Try our science-backed and tasty wholefood supplement Daily30 Get our brand-new app and Gut Health Test designed by world-leading gut health and nutrition scientists to build healthy eating habits 👉 Join ZOE Follow ZOE on Instagram. Timecodes 00:00 Intro 03:19 Why peanut allergies became so common in children 08:05 Why allergies are different in every country 10:00 The hidden link between eczema and food allergies 11:14 Your gut and skin train your immune system differently 12:42 What eczema actually does to your immune system 15:15 Did hay fever barely exist 200 years ago? 17:36 Why hay fever can seriously affect your life 18:11 Hay fever may affect exam results and work performance 20:20 Most people diagnosed with penicillin allergy may not have it 22:30 90% of penicillin allergies may be wrong 25:52 The hygiene hypothesis may not explain allergies after all 28:10 The microbiome connection scientists can’t ignore 31:24 The mouse experiment that changed allergy science 34:05 The eating pattern linked to fewer allergies in children 36:35 Food allergy vs food intolerance - what’s the difference? 39:51 What anaphylaxis actually feels like in the body 43:43 Gluten allergy, celiac disease and gluten sensitivity explained 47:49 Why allergy blood tests can give misleading results 49:46 The new treatment changing peanut allergy care 52:41 5 science-backed ways to reduce hay fever symptoms 55:16 The antihistamines some doctors now avoid 56:40 The future of allergy treatment is changing fast 📚Books by our ZOE Scientists The Food For Life Cookbook Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Ferment by Prof. Tim Spector Good Mood Food (preorder) by Prof. Tim Spector Free resources from ZOE The Hormone Harmony Guide: Tuning Your Body’s Internal Orchestra Eating for Better Brain Health: Your brain-gut blueprint How to eat in 2026 - Discover ZOE’s 8 nutrition principles for long-term health Live Healthier: Top 10 Tips From ZOE Science & Nutrition Gut Guide - For a Healthier Microbiome in Weeks Better Breakfast Guide Mentioned in today's episode Professor Adam Fox OBE uses Instagram to share clear bite-sized insights on children’s allergies, eczema & other allergic diseases - Follow at @DrAdamFox Rising Trends in Food Allergies, The Lancet (2024) Pollen exposure and exam performance, Journal of Epidemiology and Community Health (2026) Almost nine in ten patients labelled allergic to penicillin had no allergy, The Lancet (2025) Risk Factors for the Development of Food Allergy, JAMA (2026) Food Allergy and the Microbiome, Current Research in Microbial Sciences (2025) Have feedback or a topic you'd like us to cover? Let us know here. Episode transcripts are available here.

Is gut health just about taking a probiotic? Or could the bacteria in your gut be shaping your body fat, inflammation and cholesterol? In this episode, Professor Nicola Segata, a pioneer of new gut technology, and ZOE’s Chief Scientist Professor Sarah Berry, explain a major breakthrough in gut science. After analysing more than 34,000 microbiomes, the team identified 50 gut bacteria strongly linked to better health. Even more striking, many of them were previously unknown to science. Nicola explains how his team ranked hundreds of gut bacteria to define the “top 50” linked to better health, and explore how these bacteria group into patterns connected to inflammation, blood sugar, heart health and body fat. We uncover how you can improve your overall health in weeks by optimising your microbiome, ask whether probiotics do what we think they do, and examine why plant diversity may matter more than any single supplement. This episode also reveals what happened when these findings were tested in trials, and why the results surprised even the scientists. Are you feeding the right gut bacteria? And, if not, what will happen to your health if you start today? 🌱 Try our science-backed and tasty wholefood supplement Daily 30+ Get our brand-new app and Gut Health Test designed by world-leading gut health and nutrition scientists to build healthy eating habits 👉 Join ZOE Follow ZOE on Instagram. Timecodes 00:00 Intro 03:00 The biggest microbiome breakthrough in a decade 08:20 The problem with most gut research 10:25 Scientists identified the top 50 gut bacteria 11:05 The first real way to measure gut health 13:45 The “dark matter” scientists found in our guts 15:50 Why bad gut bacteria love sugar 16:30 The red meat chemical your microbes can create 18:30 The microbiome score out of 1,000 21:10 Why your microbiome is easier to change than your body 23:15 Old microbiome tests can reveal new discoveries 25:30 The 4 microbiome clusters linked to health 26:40 The gut clusters linked to inflammation, cholesterol and body fat 28:05 Why one “good bug” isn’t enough 31:25 Can diet really change your microbiome in weeks? 32:25 What happened when people changed their diet 35:10 The gold-standard trials behind this research 36:10 Why you can’t just take good bacteria in a pill 40:35 Probiotics vs prebiotics: the surprising result 41:50 The 30-plant result that shocked scientists 44:05 Why modern diets may starve our microbiome 46:10 You can pick up gut microbes from other people 47:45 Why one fibre supplement won’t fix your gut 50:35 The menopause example that shows gut bugs matter 54:30 What happens to your microbiome after antibiotics 58:35 The simple resistant starch gut health hack 📚Books by our ZOE Scientists The Food For Life Cookbook Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Ferment by Prof. Tim Spector Free resources from ZOE The Hormone Harmony Guide: Tuning Your Body’s Internal Orchestra Eating for Better Brain Health: Your brain-gut blueprint How to eat in 2026 - Discover ZOE’s 8 nutrition principles for long-term health Live Healthier: Top 10 Tips From ZOE Science & Nutrition Gut Guide - For a Healthier Microbiome in Weeks Better Breakfast Guide Mentioned in today's episode Huge microbiome breakthrough from ZOE, thanks to community science Does ZOE work? The evidence Introducing gut bug clusters Sending babies to nursery completely reshapes their microbiomes, Nature (2026) The foods you must avoid to live longer | Dan Buettner Have feedback or a topic you'd like us to cover? Let us know here. Episode transcripts are available here.